ID Q8A5X5_BACTN Unreviewed; 1042 AA.
AC Q8A5X5;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Alpha-1,2-mannosidase {ECO:0000313|EMBL:AAO77218.1};
GN OrderedLocusNames=BT_2111 {ECO:0000313|EMBL:AAO77218.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO77218.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO77218.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO77218.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
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DR EMBL; AE015928; AAO77218.1; -; Genomic_DNA.
DR RefSeq; NP_811024.1; NC_004663.1.
DR RefSeq; WP_011108138.1; NC_004663.1.
DR AlphaFoldDB; Q8A5X5; -.
DR STRING; 226186.BT_2111; -.
DR BindingDB; Q8A5X5; -.
DR ChEMBL; CHEMBL3885801; -.
DR CAZy; GH92; Glycoside Hydrolase Family 92.
DR PaxDb; 226186-BT_2111; -.
DR DNASU; 1073738; -.
DR EnsemblBacteria; AAO77218; AAO77218; BT_2111.
DR GeneID; 60928099; -.
DR KEGG; bth:BT_2111; -.
DR PATRIC; fig|226186.12.peg.2173; -.
DR eggNOG; COG3537; Bacteria.
DR HOGENOM; CLU_003690_2_1_10; -.
DR InParanoid; Q8A5X5; -.
DR OrthoDB; 9762711at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0000224; F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006516; P:glycoprotein catabolic process; IBA:GO_Central.
DR GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IBA:GO_Central.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 1.20.1050.60; alpha-1,2-mannosidase; 1.
DR Gene3D; 1.20.1610.10; alpha-1,2-mannosidases domains; 1.
DR Gene3D; 3.30.2080.10; GH92 mannosidase domain; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR005887; GH92_a_mannosidase_put.
DR InterPro; IPR041371; GH92_N.
DR InterPro; IPR012939; Glyco_hydro_92.
DR InterPro; IPR029411; RG-lyase_III.
DR NCBIfam; TIGR01180; aman2_put; 1.
DR PANTHER; PTHR12143; PEPTIDE N-GLYCANASE PNGASE -RELATED; 1.
DR PANTHER; PTHR12143:SF39; SECRETED PROTEIN-RELATED; 1.
DR Pfam; PF14683; CBM-like; 1.
DR Pfam; PF07971; Glyco_hydro_92; 1.
DR Pfam; PF17678; Glyco_hydro_92N; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1042
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004303424"
FT DOMAIN 25..195
FT /note="Rhamnogalacturonan lyase"
FT /evidence="ECO:0000259|Pfam:PF14683"
FT DOMAIN 306..548
FT /note="Glycosyl hydrolase family 92 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17678"
FT DOMAIN 554..1033
FT /note="Glycosyl hydrolase family 92"
FT /evidence="ECO:0000259|Pfam:PF07971"
SQ SEQUENCE 1042 AA; 118727 MW; B322938F561D5211 CRC64;
MKRIPLSLFT FLFLLSGLCA APTKTVWQIG EKNHSASELA LSPDKYKEFL ANDFGWEDRF
YIIGLSSPQK DFPYVLPGPA DHWGGTSYTA GIRTHVLNIL FGMKEVPETD SWKLIIDLLD
THHELPALFK ITINGKSWKY ALPKGSGKSI DGDYSQIKPH TIEIPLNSGV IRKGSNSIAL
TSLEGSWILF DDIRLMGPDN AELNEVNKSV YLRDVKAADF QTTSPVAQPL LVDIEHLSGH
PLLEVKVDGK KILEQRLEKG RYILEAPMPV VKSPKTSHYI ISADGAILDK GMIRRAPHNT
ITLADYIDTR MGTAHSRWMI APGTWMPFSM VKLSPDNQDS GWQSGYDPSF ESIGTFSHIH
EWTMAGLGIM PANGPLKTEI GSQSSLVKDA NSYRSAIDKT SEETKVGYYK VDLTDYQIKA
ELTATSRCGF QRYTYPQDKD ARVMIDLKIP SEYDYQIVEG SVKQTGARRI EGFSKQLSKN
VWSADADQNY TIYFVIEFNK DIKKFGGWHD HTLWETDTMT AHYPQRFGCY AEFDTTDHPE
VMVRSGISYV DMAGASNNLS NEITEPFGWN FEAVHKHQSD SWNNILNRVR IYSNDYREKV
RFYTNLYRAF CRNTFSDADR RWVDAAGNIQ KLDDPDAVAL GCDAFWNTFW NLNQVWNLIA
PEWSSRWVKS QLAMYDANGW LAKGPSGMKY IPVMVGEHEI PLLVSTYQMG IRNYDAEKMF
RAIVKMQTTP AQRVANGFAG NRDLETYLQH QYVPADKGRF SNTLEYSYDD WTVSQLAKAL
GKEEYYRTFS NRGNWWKNAI NPATGYAQMR YSNGEWEKNF DPFKSGANHH YVEGNAWQLT
FFVPQNVPAL TEIIGKELFI DRLSWGFKAS EPWRYNAPGD QYWDFPVVQG NQQSMHFAFL
FNWAGQPWQT QRWSRSIIDR YYGFDTSNAY LGDEDQGQMS AWFVMAALGL FQTDGGCNAE
PVYELGSPLF EKIKIDLGKH FGRGKQFIIK ASNTSRENKY IQSAKLNGKK LNSFKFPAKE
LLKGGTLELE MGDRPNKNWG IK
//
