ID Q8A5Z6_BACTN Unreviewed; 715 AA.
AC Q8A5Z6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN OrderedLocusNames=BT_2090 {ECO:0000313|EMBL:AAO77197.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO77197.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO77197.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO77197.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- COFACTOR:
CC Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC Evidence={ECO:0000256|ARBA:ARBA00001922};
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC {ECO:0000256|ARBA:ARBA00008465}.
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DR EMBL; AE015928; AAO77197.1; -; Genomic_DNA.
DR RefSeq; NP_811003.1; NC_004663.1.
DR RefSeq; WP_008759796.1; NZ_UYXG01000035.1.
DR AlphaFoldDB; Q8A5Z6; -.
DR SMR; Q8A5Z6; -.
DR STRING; 226186.BT_2090; -.
DR PaxDb; 226186-BT_2090; -.
DR EnsemblBacteria; AAO77197; AAO77197; BT_2090.
DR GeneID; 60928078; -.
DR KEGG; bth:BT_2090; -.
DR PATRIC; fig|226186.12.peg.2151; -.
DR eggNOG; COG1884; Bacteria.
DR eggNOG; COG2185; Bacteria.
DR HOGENOM; CLU_009523_3_1_10; -.
DR InParanoid; Q8A5Z6; -.
DR OrthoDB; 9762378at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031419; F:cobalamin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IBA:GO_Central.
DR GO; GO:0019678; P:propionate metabolic process, methylmalonyl pathway; IBA:GO_Central.
DR CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR CDD; cd03679; MM_CoA_mutase_alpha_like; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR InterPro; IPR006159; Acid_CoA_mut_C.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR InterPro; IPR006098; MMCoA_mutase_a_cat.
DR NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF01642; MM_CoA_mutase; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS00544; METMALONYL_COA_MUTASE; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414}.
FT DOMAIN 586..715
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 715 AA; 78700 MW; E577D1A1470025D7 CRC64;
MRKDFKNLDI YAAFQPANGA EWQKANGISA DWNTPEHIDV KPVYTKEDLE GMEHLGYAAG
LPPYLRGPYS VMYTLRPWTI RQYAGFSTAE ESNAFYRRNL ASGQKGLSVA FDLATHRGYD
PDHERVVGDV GKAGVSICSL ENMKVLFDGI PLSKMSVSMT MNGAVLPIMA FYINAGLEQG
AKLEEMAGTI QNDILKEFMV RNTYIYPPAF SMKIISDIFE YTSQKMPKFN SISISGYHMQ
EAGATADIEL AYTLADGLEY LRAGTAAGID IDAFAPRLSF FWAIGTNHFM EIAKMRAARM
LWAKIVKQFN PKNPKSLALR THSQTSGWSL TEQDPFNNVG RTCIEAMAAA LGHTQSLHTN
ALDEAIALPT DFSARIARNT QIYIQEETYI CKNVDPWGGS YYVEALTNEL AHKAWERIEE
VEKLGGMAKA IETGIPKMRI EEAAARTQAR IDSGSQTIVG VNKYRLEKEA PIDILEIDNT
AVRLEQIENL KRLKEGRNQA EVDKALAAIT ECVETGKGNL LELAVEAARV RATLGEISYA
CEKVVGRYKA IIRTISGVYS SESKNDGDFK RACELAEKFA KKEGRQPRIM VAKMGQDGHD
RGAKVVATGY ADCGFDVDMG PLFQTPAEAA REAVENDVHV VGVSSLAAGH KTLIPQIMEE
LKKLGREDIV VIAGGVIPAQ DYDFLYKAGV AAIFGPGTPV AKAACQILEI LMDEE
//