ID Q8A6G0_BACTN Unreviewed; 255 AA.
AC Q8A6G0;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Metal-dependent hydrolase {ECO:0000313|EMBL:AAO77031.1};
GN OrderedLocusNames=BT_1924 {ECO:0000313|EMBL:AAO77031.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO77031.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO77031.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO77031.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
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DR EMBL; AE015928; AAO77031.1; -; Genomic_DNA.
DR RefSeq; NP_810837.1; NC_004663.1.
DR RefSeq; WP_008766271.1; NC_004663.1.
DR AlphaFoldDB; Q8A6G0; -.
DR STRING; 226186.BT_1924; -.
DR PaxDb; 226186-BT_1924; -.
DR EnsemblBacteria; AAO77031; AAO77031; BT_1924.
DR GeneID; 60927908; -.
DR KEGG; bth:BT_1924; -.
DR PATRIC; fig|226186.12.peg.1975; -.
DR eggNOG; COG2220; Bacteria.
DR HOGENOM; CLU_070010_0_0_10; -.
DR InParanoid; Q8A6G0; -.
DR OrthoDB; 9789133at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR43546:SF3; UPF0173 METAL-DEPENDENT HYDROLASE MJ1163; 1.
DR PANTHER; PTHR43546; UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED; 1.
DR Pfam; PF13483; Lactamase_B_3; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:AAO77031.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..255
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004303429"
FT DOMAIN 55..228
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 255 AA; 28857 MW; 9EAAAB1127A11395 CRC64;
MKKILLVALA LCLSYGFAYS CLFNHSINLT TKMQNFETDS FTTKNGKSLK ITFFKHASLL
IEYAGKKFFV DPVSDYADFT QQPKADYILI THEHHDHFDT KAIAAIETPD TKIIANPNCQ
KMLDKGQAMK NGDILQITPE IKLEAVPAYN TTPGRDKFHP KGRDNGYILT VGGTRIYIAG
DTEDIPEMKQ IKNIDIAFLP VNQPYTMTPE QAIQSAKTIQ PHILYPYHYG DTNINEVKDG
LKNEKEIEVR IRALQ
//
