ID Q8A6K2_BACTN Unreviewed; 592 AA.
AC Q8A6K2;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Protease IV {ECO:0000313|EMBL:AAO76986.1};
GN OrderedLocusNames=BT_1879 {ECO:0000313|EMBL:AAO76986.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO76986.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO76986.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO76986.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
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DR EMBL; AE015928; AAO76986.1; -; Genomic_DNA.
DR RefSeq; NP_810792.1; NC_004663.1.
DR RefSeq; WP_008765466.1; NZ_UYXG01000021.1.
DR AlphaFoldDB; Q8A6K2; -.
DR STRING; 226186.BT_1879; -.
DR PaxDb; 226186-BT_1879; -.
DR EnsemblBacteria; AAO76986; AAO76986; BT_1879.
DR GeneID; 60927866; -.
DR KEGG; bth:BT_1879; -.
DR PATRIC; fig|226186.12.peg.1931; -.
DR eggNOG; COG0616; Bacteria.
DR HOGENOM; CLU_008856_1_1_10; -.
DR InParanoid; Q8A6K2; -.
DR OrthoDB; 9764363at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd07018; S49_SppA_67K_type; 1.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004634; Pept_S49_pIV.
DR InterPro; IPR004635; Pept_S49_SppA.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047217; S49_SppA_67K_type_N.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00705; SppA_67K; 1.
DR NCBIfam; TIGR00706; SppA_dom; 1.
DR PANTHER; PTHR33209; PROTEASE 4; 1.
DR PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:AAO76986.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..279
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 375..524
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT ACT_SITE 193
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT ACT_SITE 392
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ SEQUENCE 592 AA; 65407 MW; 97E70CE53B4736E6 CRC64;
MKDFLKFTLA TVTGIILSSI VLFIIGMVTL FGIVSTADTE TIVKKNSVMM LDLNGVLVER
TQESPLGILS QLFSDDSNTY GLDDILSSIK KAKENENIKG IYLQASMLGT SYASLQEIRN
ALLDFKESGK FIIAYGDSYT QGLYYLSSVA DKVLLNPKGM IEWKGIASAP LFYKDLLQKI
GVEMQIFKVG TYKSAVEPFI STEMSPANRE QVTAFINSIW GQVTEGVSAS RSLPVDSLNA
LADRMLMFYP AEESVQCGLA DTLIYRNDVR NYLKQWVDLK EDDRLPVLGL SDMINVKKNM
PKDKSGNIVA VYYASGEITD YSGSSTSEEG IVGTKVIRDL RKLKDDEDVK AVVLRVNSPG
GSAFASEQIW HAVKELKTEK PVIVSMGDYA ASGGYYISCV ADTIVAEPTT LTGSIGIFGM
VPNVKELSEK IGLTYDVVKT NKFSDFGNIM RPFNQDEKTL MQMMITQGYD TFVNRCAEGR
HMSKEAIEKI AEGRVWTGEA AKELGLVDVL GGIDTALEIA VRKAGIEGYT VVSYPAKQDL
LSSLLNTKPT NYVESQILKS KLGEYYQQFG MLKNLKERSM IQARIPFELN IK
//
