ID Q8A7A4_BACTN Unreviewed; 519 AA.
AC Q8A7A4;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN OrderedLocusNames=BT_1621 {ECO:0000313|EMBL:AAO76728.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO76728.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO76728.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO76728.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; AE015928; AAO76728.1; -; Genomic_DNA.
DR RefSeq; NP_810534.1; NC_004663.1.
DR RefSeq; WP_011107895.1; NC_004663.1.
DR AlphaFoldDB; Q8A7A4; -.
DR STRING; 226186.BT_1621; -.
DR CAZy; GH20; Glycoside Hydrolase Family 20.
DR PaxDb; 226186-BT_1621; -.
DR EnsemblBacteria; AAO76728; AAO76728; BT_1621.
DR GeneID; 60927606; -.
DR KEGG; bth:BT_1621; -.
DR PATRIC; fig|226186.12.peg.1659; -.
DR eggNOG; COG3525; Bacteria.
DR HOGENOM; CLU_007082_5_1_10; -.
DR InParanoid; Q8A7A4; -.
DR OrthoDB; 1090159at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IBA:GO_Central.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0030203; P:glycosaminoglycan metabolic process; IBA:GO_Central.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..519
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004306607"
FT DOMAIN 23..139
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 143..477
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 304
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 519 AA; 59839 MW; DF25EDE0A6677744 CRC64;
MKHLIFTALF LLSYTVAVRA QIVFPTPNQV EMQTGNLILG KKVSMYAEDT TAFYLNLFRE
EVLSHTPIKW QKKESKADIC WITDSSLPPE GYRIKIHPQQ MVISASDKGG FTYAVQTLRQ
WVAGSAGSIT FACASVTDYP RTQWRCFLLD SGRQFQKITT IRKYIDMASL LKMNYFHWHL
TEGLGWRIEI KQYPHLTRTG GSVGKGEEQQ GFYTQEEIRD IIEYARQRNI TIVPEIDMPG
HAEAALSAYP ELGCFGLPVE IPQSGFTQNI FCAGKDGTLR FLKNVLDEVC ALFPSPYIHL
GGDEAPKGNW DQCPDCRKRI TTEGLKDSHD LQLWFSAQMA NYLKSKGRKA IFWGDVVYHD
GYPLPDNTVI QWWNYRGHKD LALRNAVKHH YPVICSSNYY TYLNFPVTPW KGYTEARTFD
LKDVYLNNPS DKAISEKNPL ILGMSCALWT DDGVTERMID RRLFPRILAL SEQMWHEGEA
LDFDRFYRNI LHRKAWFEEA GFEFGPALKE DVTKDYKWD
//
