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Database: UniProt
Entry: Q8AA95
LinkDB: Q8AA95
Original site: Q8AA95 
ID   UVRB_BACTN              Reviewed;         677 AA.
AC   Q8AA95;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   16-OCT-2019, entry version 103.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204};
GN   OrderedLocusNames=BT_0570;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC
OS   10582 / E50 / VPI-5482).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K.,
RA   Chiang H.C., Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
DR   EMBL; AE015928; AAO75677.1; -; Genomic_DNA.
DR   RefSeq; NP_809483.1; NC_004663.1.
DR   RefSeq; WP_008763156.1; NZ_UYXG01000009.1.
DR   SMR; Q8AA95; -.
DR   STRING; 226186.BT_0570; -.
DR   PaxDb; Q8AA95; -.
DR   PRIDE; Q8AA95; -.
DR   EnsemblBacteria; AAO75677; AAO75677; BT_0570.
DR   GeneID; 1072113; -.
DR   KEGG; bth:BT_0570; -.
DR   PATRIC; fig|226186.12.peg.571; -.
DR   eggNOG; ENOG4105CCW; Bacteria.
DR   eggNOG; COG0556; LUCA.
DR   InParanoid; Q8AA95; -.
DR   KO; K03702; -.
DR   OMA; RYMHSEI; -.
DR   BioCyc; BTHE:G13PU-5474-MONOMER; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR041471; UvrB_inter.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome;
KW   SOS response.
FT   CHAIN         1    677       UvrABC system protein B.
FT                                /FTId=PRO_0000227288.
FT   DOMAIN       24    412       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      429    591       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      636    671       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      37     44       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF        90    113       Beta-hairpin.
SQ   SEQUENCE   677 AA;  77113 MW;  D915939CCB40898C CRC64;
     MNFELTSAYK PTGDQPEAIA QLTEGVLQGV PAQTLLGVTG SGKTFTIANV IANINKPTLI
     LSHNKTLAAQ LYSEFKGFFP NNAVEYYVSY YDYYQPEAYL PNSDTYIEKD LAINDEIDKL
     RLAATSSLLS GRKDVVVVSS VSCIYGMGNP SDFYKNVIEI ERGRMLDRNV FLRRLVDSLY
     VRNDIDLNRG NFRVKGDTVD IFLAYSDTLL RVTFWGDEID GIEEVDPITG VTTAPFEAYK
     IYPANLFMTT KEATLRAIHE IEDDLTKQVA FFESIGKEYE AKRLYERVTY DMEMIRELGH
     CSGIENYSRY FDGRAAGTRP YCLLDFFPDD FLLVIDESHV SVPQVRAMYG GDRARKINLV
     EYGFRLPAAM DNRPLKFEEF EEMTKQVIYV SATPAEYELI QSEGIVVEQV IRPTGLLDPV
     IEVRPSLNQI DDLMEEIQLR IEKEERVLVT TLTKRMAEEL TEYLLNNNVR CNYIHSDVDT
     LERVKIMDDL RQGVYDVLIG VNLLREGLDL PEVSLVAILD ADKEGFLRSH RSLTQTAGRA
     ARNVNGKVIM YADKITDSMR LTIDETNRRR EKQLAYNEAN GITPQQIKKA RNLSVFGSPG
     SEADELLKEK HAYVEPSSPN IAADPIVQYM SKAQMEKSIE RTRKLMQEAA KKLEFIEAAQ
     YRNELLKLED LMKEKWG
//
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