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Database: UniProt
Entry: Q8AII3_SIV
LinkDB: Q8AII3_SIV
Original site: Q8AII3_SIV 
ID   Q8AII3_SIV              Unreviewed;       185 AA.
AC   Q8AII3;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   12-AUG-2020, entry version 87.
DE   RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344};
GN   Name=nef {ECO:0000313|EMBL:AAN85713.1};
OS   Simian immunodeficiency virus SIV-mnd 2.
OC   Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=159122 {ECO:0000313|EMBL:AAN85713.1, ECO:0000313|Proteomes:UP000204000};
RN   [1] {ECO:0000313|EMBL:AAN85713.1, ECO:0000313|Proteomes:UP000204000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIVmnd-2 {ECO:0000313|EMBL:AAN85713.1};
RX   PubMed=11522184; DOI=10.1089/088922201316912754;
RA   Takehisa J., Harada Y., Ndembi N., Mboudjeka I., Taniguchi Y., Ngansop C.,
RA   Kuate S., Zekeng L., Ibuki K., Shimada T., Bikandou B.,
RA   Yamaguchi-Kabata Y., Miura T., Ikeda M., Ichimura H., Kaptue L., Hayami M.;
RT   "Natural infection of wild-born mandrills (Mandrillus sphinx) with two
RT   different types of simian immunodeficiency virus.";
RL   AIDS Res. Hum. Retroviruses 17:1143-1154(2001).
CC   -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein family.
CC       {ECO:0000256|ARBA:ARBA00006933, ECO:0000256|RuleBase:RU000344}.
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DR   EMBL; AF367411; AAN85713.1; -; Genomic_DNA.
DR   RefSeq; NP_758893.1; NC_004455.1.
DR   GeneID; 956109; -.
DR   KEGG; vg:956109; -.
DR   KO; K22891; -.
DR   Proteomes; UP000204000; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.62.10; -; 1.
DR   InterPro; IPR027481; HIV-1_Nef_core_sf.
DR   InterPro; IPR001558; HIV_Nef.
DR   Pfam; PF00469; F-protein; 1.
DR   SUPFAM; SSF55671; SSF55671; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Lipoprotein {ECO:0000256|RuleBase:RU000344};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|RuleBase:RU000344};
KW   Reference proteome {ECO:0000313|Proteomes:UP000204000};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280,
KW   ECO:0000256|RuleBase:RU000344};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026, ECO:0000256|RuleBase:RU000344}.
FT   REGION          28..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..46
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   185 AA;  21226 MW;  C14324AC951AA4D1 CRC64;
     MGGKSSKQQE EKYLKYYKAM RRGYGAEGTN GDYQQLHASE PLLGALSTSQ EEFDREQKSS
     STDEEEETGF PVYPQCPVRE PTYKDLVDMP HFLKEKGGLE GIWHSKRREE ILDLYAQNEW
     GFIPTWQSYT DGPGIRYPKT FRFLFKLCPV AVPPDQENNE CNKLLQSSQL GIQEESLGRE
     ASVEV
//
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