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Database: UniProt
Entry: Q8AII8_SIV
LinkDB: Q8AII8_SIV
Original site: Q8AII8_SIV 
ID   Q8AII8_SIV              Unreviewed;       212 AA.
AC   Q8AII8;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   10-FEB-2021, entry version 80.
DE   RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341};
GN   Name=vif {ECO:0000313|EMBL:AAN85709.1};
OS   Simian immunodeficiency virus SIV-mnd 2.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=159122 {ECO:0000313|EMBL:AAN85709.1, ECO:0000313|Proteomes:UP000204000};
RN   [1] {ECO:0000313|EMBL:AAN85709.1, ECO:0000313|Proteomes:UP000204000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIVmnd-2 {ECO:0000313|EMBL:AAN85709.1};
RX   PubMed=11522184; DOI=10.1089/088922201316912754;
RA   Takehisa J., Harada Y., Ndembi N., Mboudjeka I., Taniguchi Y., Ngansop C.,
RA   Kuate S., Zekeng L., Ibuki K., Shimada T., Bikandou B.,
RA   Yamaguchi-Kabata Y., Miura T., Ikeda M., Ichimura H., Kaptue L., Hayami M.;
RT   "Natural infection of wild-born mandrills (Mandrillus sphinx) with two
RT   different types of simian immunodeficiency virus.";
RL   AIDS Res. Hum. Retroviruses 17:1143-1154(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC       Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|RuleBase:RU003341};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004501,
CC       ECO:0000256|RuleBase:RU003341}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|RuleBase:RU003341}. Host
CC       cytoplasm {ECO:0000256|RuleBase:RU003341}. Virion
CC       {ECO:0000256|RuleBase:RU003341}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}. Note=In the cytoplasm, seems to
CC       colocalize with intermediate filament vimentin. A fraction is
CC       associated with the cytoplasmic side of cellular membranes, presumably
CC       via the interaction with Pr55Gag precursor.
CC       {ECO:0000256|RuleBase:RU003341}.
CC   -!- SIMILARITY: Belongs to the primate lentivirus group Vif protein family.
CC       {ECO:0000256|ARBA:ARBA00006372, ECO:0000256|RuleBase:RU003341}.
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DR   EMBL; AF367411; AAN85709.1; -; Genomic_DNA.
DR   RefSeq; NP_758888.1; NC_004455.1.
DR   GeneID; 956111; -.
DR   KEGG; vg:956111; -.
DR   Proteomes; UP000204000; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR000475; Vif.
DR   Pfam; PF00559; Vif; 1.
DR   PRINTS; PR00349; VIRIONINFFCT.
PE   3: Inferred from homology;
KW   Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   REGION          161..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   212 AA;  25125 MW;  6065FEEBDE9EAFFF CRC64;
     MEKQWIVIPT WKLDRHAVER WNSLVKYHKY KGEKHLDKWD LKAHFQCSGW WTHSQKYIPL
     EEDEQIIITI LWNLTPEKGW LSTYAMTIEY KFTNYYTHID PQTADRMIHW KYLPCFTEQA
     IRQALLGKRL TVCYFHWGHK GKVGSLQYLA LLSYTAYCNN GRRGPRDPRR SRRGGSKYLV
     GKISGENQSG GKITLPPRVP FPSLERMHRT LA
//
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