ID Q8AVK6_XENLA Unreviewed; 281 AA.
AC Q8AVK6;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Flj12750-prov protein {ECO:0000313|EMBL:AAH42220.1};
GN Name=vps37b.L {ECO:0000313|RefSeq:NP_001080146.1,
GN ECO:0000313|Xenbase:XB-GENE-17330102};
GN Synonyms=flj12750 {ECO:0000313|RefSeq:NP_001080146.1}, vps37b
GN {ECO:0000313|Xenbase:XB-GENE-17330102};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH42220.1};
RN [1] {ECO:0000313|RefSeq:NP_001080146.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH42220.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH42220.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001080146.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR EMBL; BC042220; AAH42220.1; -; mRNA.
DR RefSeq; NP_001080146.1; NM_001086677.1.
DR STRING; 8355.Q8AVK6; -.
DR PaxDb; 8355-Q8AVK6; -.
DR DNASU; 379838; -.
DR GeneID; 379838; -.
DR KEGG; xla:379838; -.
DR AGR; Xenbase:XB-GENE-17330102; -.
DR Xenbase; XB-GENE-17330102; vps37b.L.
DR OMA; EGRNCCS; -.
DR OrthoDB; 5361270at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 379838; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0000813; C:ESCRT I complex; IEA:UniProt.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF9; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37B; 1.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 82..171
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT REGION 180..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..125
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 194..210
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..239
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..281
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 31473 MW; AEE80FF67D6C5219 CRC64;
MAFDTTKFMQ LSLTQLNELL DDEEKLGQVV QEMDETQNVQ LSKEMTLAGN RSLAEENLLL
QPDLENLKAT LTQKYQELQS LLESHQLKKT KLDKQSVNSS LETLLALLQA EGAKIEEETE
NMAENFLDGG IQLENFTDEY LNKRKLAHLR RVKIEKLQEM VMKGQRLPQV SVLPQTHPLE
SNQAPQASYP ANITPRRPVP PPPQAPSQPG LYPMPYAMAA QPAPGLPYAP SPCPPLPSRH
GYQPSNQMPQ PGYPAPFTQQ YPPALPQRPP RLPPMPGFIA Q
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