ID Q8AVS7_XENLA Unreviewed; 153 AA.
AC Q8AVS7;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Caveolin {ECO:0000256|RuleBase:RU000680};
GN Name=cav3.2.S {ECO:0000313|RefSeq:NP_001080174.1,
GN ECO:0000313|Xenbase:XB-GENE-5815140};
GN Synonyms=cav-3 {ECO:0000313|RefSeq:NP_001080174.1}, cav3
GN {ECO:0000313|RefSeq:NP_001080174.1,
GN ECO:0000313|Xenbase:XB-GENE-5815140}, cav3.2
GN {ECO:0000313|RefSeq:NP_001080174.1,
GN ECO:0000313|Xenbase:XB-GENE-5815140}, caveolin-3
GN {ECO:0000313|RefSeq:NP_001080174.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH41289.1};
RN [1] {ECO:0000313|RefSeq:NP_001080174.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH41289.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH41289.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001080174.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes.
CC Interacts directly with G-protein alpha subunits and can functionally
CC regulate their activity. {ECO:0000256|RuleBase:RU000680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|RuleBase:RU000680}. Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU000680}. Membrane, caveola
CC {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU000680}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the caveolin family.
CC {ECO:0000256|ARBA:ARBA00010988, ECO:0000256|RuleBase:RU000680}.
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DR EMBL; BC041289; AAH41289.1; -; mRNA.
DR RefSeq; NP_001080174.1; NM_001086705.1.
DR STRING; 8355.Q8AVS7; -.
DR PaxDb; 8355-Q8AVS7; -.
DR DNASU; 379866; -.
DR GeneID; 379866; -.
DR KEGG; xla:379866; -.
DR AGR; Xenbase:XB-GENE-5815140; -.
DR CTD; 379866; -.
DR Xenbase; XB-GENE-5815140; cav3.2.S.
DR OMA; CRINCHV; -.
DR OrthoDB; 3740765at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 379866; Expressed in muscle tissue and 9 other cell types or tissues.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0070836; P:caveola assembly; IEA:InterPro.
DR InterPro; IPR001612; Caveolin.
DR InterPro; IPR018361; Caveolin_CS.
DR PANTHER; PTHR10844; CAVEOLIN; 1.
DR PANTHER; PTHR10844:SF16; CAVEOLIN-3; 1.
DR Pfam; PF01146; Caveolin; 1.
DR PROSITE; PS01210; CAVEOLIN; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|RuleBase:RU000680};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU000680};
KW Membrane {ECO:0000256|RuleBase:RU000680, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 81..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 153 AA; 17236 MW; A1611B68CCD223C9 CRC64;
MAQIQQPEPA KQDKSNTEAL TKEIDLVQRD PKKINQEVVQ VDFEDVIAEP DGTHSFDGVW
KASSSTFTVT KYWCYRVLSA IFGLPLALLW GFLFACLSFC QIWAVVPCVK SYLMEVQCLG
QFYALCVRTF CDPIFEAMGK VLGGIRVALR KEA
//
