ID Q8AXP7_TETNG Unreviewed; 137 AA.
AC Q8AXP7;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=(spotted green pufferfish) hypothetical protein {ECO:0000313|EMBL:CAF99479.1};
DE SubName: Full=Cholecystokinin {ECO:0000313|EMBL:BAC44894.1};
GN Name=CCK1 {ECO:0000313|EMBL:BAC44894.1};
GN ORFNames=GSTENG00017572001 {ECO:0000313|EMBL:CAF99479.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:BAC44894.1};
RN [1] {ECO:0000313|EMBL:BAC44894.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAC44894.1};
RX PubMed=12668207; DOI=10.1016/S0196-9781(03)00034-2;
RA Kurokawa T., Suzuki T., Hashimoto H.;
RT "Identification of gastrin and multiple cholecystokinin genes in teleost.";
RL Peptides 24:227-235(2003).
RN [2] {ECO:0000313|EMBL:CAF99479.1, ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [3] {ECO:0000313|EMBL:CAF99479.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSTNIP00000012113.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU004362}.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000256|ARBA:ARBA00006273, ECO:0000256|RuleBase:RU004362}.
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DR EMBL; AB086401; BAC44894.1; -; mRNA.
DR EMBL; CAAE01014577; CAF99479.1; -; Genomic_DNA.
DR STRING; 99883.ENSTNIP00000012113; -.
DR Ensembl; ENSTNIT00000012304.1; ENSTNIP00000012113.1; ENSTNIG00000009248.1.
DR KEGG; tng:GSTEN00017572G001; -.
DR GeneTree; ENSGT00390000003571; -.
DR HOGENOM; CLU_169783_0_0_1; -.
DR TreeFam; TF333419; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007586; P:digestion; IEA:InterPro.
DR InterPro; IPR015499; CCK-like.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PANTHER; PTHR10786; CHOLECYSTOKININ; 1.
DR PANTHER; PTHR10786:SF0; CHOLECYSTOKININ; 1.
DR Pfam; PF00918; Gastrin; 1.
DR SMART; SM00029; GASTRIN; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 2: Evidence at transcript level;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..137
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014107261"
FT DOMAIN 4..137
FT /note="Gastrin/cholecystokinin peptide hormone"
FT /evidence="ECO:0000259|Pfam:PF00918"
SQ SEQUENCE 137 AA; 14825 MW; E8DF839D8F750E89 CRC64;
MAAGLCACVV LAVLCTGCFG LPFSSRLLEE GRRSAPAPYE GALLKADGRQ AGEAPVRHRR
SASQLNALPL PEETDSRANL SELLARLIST RKGSVRRNST ANSRGVGLGA NHRIADRDYL
GWMDFGRRSA EEYEYSS
//
