ID SHC1_XENLA Reviewed; 465 AA.
AC Q8AY68; Q5FWW5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=SHC-transforming protein 1;
DE AltName: Full=Src homology 2 domain-containing-transforming protein C1;
DE Short=SH2 domain protein C1;
DE AltName: Full=p60Shc;
GN Name=shc1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12941529; DOI=10.1016/s0248-4900(03)00058-3;
RA Chesnel F., Heligon C., Richard-Parpaillon L., Boujard D.;
RT "Molecular cloning and characterization of an adaptor protein Shc isoform
RT from Xenopus laevis oocytes.";
RL Biol. Cell 95:311-320(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Implicated in ras-dependent oocyte maturation induced by
CC insulin/IGF-1. {ECO:0000269|PubMed:12941529}.
CC -!- SUBUNIT: Interacts with grb2.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in oocytes and embryo. Also
CC expressed in liver. Detected in ovary, testis and heart and to a lesser
CC extent in liver (at protein level). {ECO:0000269|PubMed:12941529}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK14789.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY027793; AAK14789.1; ALT_INIT; mRNA.
DR EMBL; BC089178; AAH89178.1; -; mRNA.
DR RefSeq; NP_001083932.1; NM_001090463.1.
DR RefSeq; XP_018084264.1; XM_018228775.1.
DR AlphaFoldDB; Q8AY68; -.
DR SMR; Q8AY68; -.
DR BioGRID; 100523; 1.
DR IntAct; Q8AY68; 1.
DR DNASU; 399198; -.
DR GeneID; 399198; -.
DR KEGG; xla:399198; -.
DR AGR; Xenbase:XB-GENE-494866; -.
DR CTD; 399198; -.
DR OrthoDB; 2903566at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 399198; Expressed in spleen and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF2; SHC-TRANSFORMING PROTEIN 1; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Growth regulation; Reference proteome; SH2 domain.
FT CHAIN 1..465
FT /note="SHC-transforming protein 1"
FT /id="PRO_0000327223"
FT DOMAIN 44..227
FT /note="PID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT DOMAIN 370..461
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 228..369
FT /note="CH1"
FT REGION 281..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 51730 MW; E0E6726579965089 CRC64;
MNKLSCGRKS RVEGGQLAGD EWTRHGSFVN KPTRGWLHPD DKVMGPGVPY LVRYMGCVEV
LQSMRALDFN TRTQVTREAI SLVCDAVPGA KGAMRRRKTC GRSLNSILGK SNLKFAGMPI
TLTVSTSSLN LMASDCKQII ANHHMQSISF ASGGDPDTAE YVAYVAKDPV NQRACHILEC
PEGLAQDVIS TIGQAFELRF KQYLKNPPKL VTPHDRMAGF DGSAWDEEEE ELPDHAYYND
FPGKEPPIGG VVDMRLRDGA APAVLRQSPN HMGATLPVGQ VSGAEQDSRK MQPTLQGRER
FPVPCSRPPN RPDLFDDPSY VNVQNLEKSR QPLRAANGQR DIFDMKPFDD ALPSAQAIVS
MEDQLKREPW YQGKMSRKEA ERLLKVNGDF LVRESTTTPG QYVLTGLQCG QPKHLLLVDP
EGVVRTKDHR FESVSHLISY HMDNHLPIIS AGSELCLQQP VERRQ
//
