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Database: UniProt
Entry: Q8BH05
LinkDB: Q8BH05
Original site: Q8BH05 
ID   ZN750_MOUSE             Reviewed;         703 AA.
AC   Q8BH05; B1ATU1; B9EKG8; Q66JP3; Q8C0L1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 133.
DE   RecName: Full=Zinc finger protein 750;
GN   Name=Znf750; Synonyms=Zfp750;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head, and Skin;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcription factor involved in epidermis differentiation.
CC       Required for terminal epidermal differentiation: acts downstream of
CC       p63/TP63 and activates expression of late epidermal differentiation
CC       genes. Specifically binds to the promoter of KLF4 and promotes its
CC       expression (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AK030690; BAC27080.1; -; mRNA.
DR   EMBL; AK037185; BAC29743.1; -; mRNA.
DR   EMBL; AK037240; BAC29771.1; -; mRNA.
DR   EMBL; AL663088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC150905; AAI50906.1; -; mRNA.
DR   CCDS; CCDS25779.1; -.
DR   RefSeq; NP_848878.1; NM_178763.4.
DR   AlphaFoldDB; Q8BH05; -.
DR   SMR; Q8BH05; -.
DR   STRING; 10090.ENSMUSP00000089951; -.
DR   PhosphoSitePlus; Q8BH05; -.
DR   PaxDb; 10090-ENSMUSP00000089951; -.
DR   ProteomicsDB; 275035; -.
DR   Antibodypedia; 19924; 133 antibodies from 27 providers.
DR   DNASU; 319530; -.
DR   Ensembl; ENSMUST00000092298.6; ENSMUSP00000089951.6; ENSMUSG00000039238.7.
DR   GeneID; 319530; -.
DR   KEGG; mmu:319530; -.
DR   UCSC; uc007mvz.2; mouse.
DR   AGR; MGI:2442210; -.
DR   CTD; 319530; -.
DR   MGI; MGI:2442210; Zfp750.
DR   VEuPathDB; HostDB:ENSMUSG00000039238; -.
DR   eggNOG; ENOG502QU7X; Eukaryota.
DR   GeneTree; ENSGT00530000063870; -.
DR   HOGENOM; CLU_023455_0_0_1; -.
DR   InParanoid; Q8BH05; -.
DR   OMA; PSAYDHY; -.
DR   OrthoDB; 5477080at2759; -.
DR   PhylomeDB; Q8BH05; -.
DR   TreeFam; TF331381; -.
DR   Reactome; R-MMU-212436; Generic Transcription Pathway.
DR   BioGRID-ORCS; 319530; 3 hits in 78 CRISPR screens.
DR   PRO; PR:Q8BH05; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8BH05; Protein.
DR   Bgee; ENSMUSG00000039238; Expressed in animal zygote and 86 other cell types or tissues.
DR   Genevisible; Q8BH05; MM.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR   GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; ISO:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR039363; ZNF750.
DR   InterPro; IPR039064; ZNF750_Znf.
DR   PANTHER; PTHR14678; UNCHARACTERIZED; 1.
DR   PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR   Pfam; PF15269; zf-C2H2_7; 1.
PE   2: Evidence at transcript level;
KW   Activator; Differentiation; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..703
FT                   /note="Zinc finger protein 750"
FT                   /id="PRO_0000247071"
FT   ZN_FING         25..51
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT   REGION          64..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          350..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          553..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..394
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..609
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..655
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         27
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT   BINDING         43
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT   BINDING         49
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT   CONFLICT        131
FT                   /note="L -> Q (in Ref. 1; BAC27080)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        421
FT                   /note="F -> L (in Ref. 1; BAC27080)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        638
FT                   /note="V -> A (in Ref. 3; AAI50906)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   703 AA;  76645 MW;  5C93367C6595BD8A CRC64;
     MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
     RIPKCPKSSS LDPKQTHQPE PTSKPATSKS LLNGLSSFDP KSQQGSAKED AKENLEMQAR
     GAHKGPQKPA LQKEMAPEAI LSTQPCLDSG VRHSAFVPVG EHRLRGPEDT EATEVLANST
     TKASSFHAKS AFHTPGYPWK AGSPFLPPDF PHKISSTKGF GAISPYMHPA IPEYPHPFYA
     EHGLAAIYSP YLLTGNTPEC ETTLLSVYGT QDQRHFLSPA GPIPKHLNTS PSTYDHYRFF
     QQYHSNLPIP YGFYRPESAF PSYSLRLPSV TGITRDQSSR LLEDATLAYP ASSPSELNLS
     SSHRKHTECE KGSPVPEAKD PSKDGQRDAE EAKMSPRAGS AATGSPGRPS PTNFTQTSQT
     FEGLCDLSNK AASSGTLERL QQAEQSPTAF KPVQRGSESP HSQPPANRTE SPKSLQAMNG
     DPPAQTGSSN SFITEAPPSS PEDHSRIGPL NLSKKLETNP AATYGPMYAS NAQADTLQDL
     PLNLSVKDLC NAWAPRPALP GPPQGAEPAA TPKTETKGSE DRTSRVETPQ DKAHSRTTPD
     VHTEDSSDEQ KQTAAVALCQ LAAYSPGNVR VADEEGTVQE PTRQDVPTLS ATENLEAQCD
     LRPKGQKRTS QRDTGKSQQG TKKPKLNDPV PRVLTLRRRT RVS
//
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