ID ZNF2_MOUSE Reviewed; 427 AA.
AC Q8BIQ3; Q7TPW3;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 162.
DE RecName: Full=Zinc finger protein 2 {ECO:0000305};
DE AltName: Full=Zinc finger protein 661;
DE Short=Zfp-661;
GN Name=Znf2 {ECO:0000312|MGI:MGI:1919430}; Synonyms=Zfp661;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK033122; BAC28161.1; -; mRNA.
DR EMBL; BC052876; AAH52876.1; -; mRNA.
DR CCDS; CCDS16705.1; -.
DR RefSeq; NP_001104499.1; NM_001111029.1.
DR RefSeq; NP_082417.3; NM_028141.3.
DR RefSeq; XP_006500290.1; XM_006500227.2.
DR RefSeq; XP_011238090.1; XM_011239788.2.
DR AlphaFoldDB; Q8BIQ3; -.
DR SMR; Q8BIQ3; -.
DR BioGRID; 215203; 1.
DR STRING; 10090.ENSMUSP00000105995; -.
DR iPTMnet; Q8BIQ3; -.
DR PhosphoSitePlus; Q8BIQ3; -.
DR jPOST; Q8BIQ3; -.
DR PaxDb; 10090-ENSMUSP00000105995; -.
DR Antibodypedia; 72445; 183 antibodies from 23 providers.
DR DNASU; 72180; -.
DR Ensembl; ENSMUST00000077422.12; ENSMUSP00000076637.6; ENSMUSG00000034800.16.
DR Ensembl; ENSMUST00000110366.8; ENSMUSP00000105995.2; ENSMUSG00000034800.16.
DR Ensembl; ENSMUST00000110368.9; ENSMUSP00000105997.3; ENSMUSG00000034800.16.
DR Ensembl; ENSMUST00000164551.2; ENSMUSP00000132820.2; ENSMUSG00000034800.16.
DR GeneID; 72180; -.
DR KEGG; mmu:72180; -.
DR UCSC; uc008mfq.2; mouse.
DR AGR; MGI:1919430; -.
DR CTD; 72180; -.
DR MGI; MGI:1919430; Zfp661.
DR VEuPathDB; HostDB:ENSMUSG00000034800; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160826; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; Q8BIQ3; -.
DR OMA; TKPEIHG; -.
DR OrthoDB; 4623148at2759; -.
DR PhylomeDB; Q8BIQ3; -.
DR TreeFam; TF340946; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 72180; 2 hits in 76 CRISPR screens.
DR PRO; PR:Q8BIQ3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BIQ3; Protein.
DR Bgee; ENSMUSG00000034800; Expressed in ureteric bud trunk and 158 other cell types or tissues.
DR Genevisible; Q8BIQ3; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 9.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF137; ZINC FINGER PROTEIN 8; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR Pfam; PF13465; zf-H2C2_2; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..427
FT /note="Zinc finger protein 2"
FT /id="PRO_0000274050"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 169..191
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 9; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 111..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 62
FT /note="V -> A (in Ref. 2; AAH52876)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="T -> A (in Ref. 2; AAH52876)"
FT /evidence="ECO:0000305"
FT CONFLICT 249
FT /note="G -> E (in Ref. 2; AAH52876)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 427 AA; 48640 MW; AC70BD8A1D246F58 CRC64;
MAAVSPPTRC QALVTFEDVA VTFTDDEWKR LVPVQRALYK AVMLENYESI ISLGLPVPRP
DVILQFKRRG EPWIRGFHGS EEKTWPESVS LDLETKPETL DASRGTLREI HRKQSSLCPK
REIQTLTGGP EPEKESPKAR TCKKPLSLDK GLHQMSAPSK KALTKHQDQE CSECGKTFFD
HSSLIRHQRT HTGEKPYDCP ECGKAFSHRS SLSRHLMFHT GESPYECDAC GKAFFDRSSL
TVHQRIHTGE KPFKCNDCGK AFFDRSSLTR HQRIHTGESP YECQQCGKAF SQKSILTRHL
LTHTGRKPYE CRDCGKAFYG VTSLNRHQKV HTEEPRYQCS ECGKAFFDRS SLTQHQKIHT
GDKPYECGEC GKAFSQRCRL TRHQRVHTGE KPFECSVCGK EFSSKSSIIQ HQRRYAKQGI
DRGGSMS
//
