GenomeNet

Database: UniProt
Entry: Q8BTK5
LinkDB: Q8BTK5
Original site: Q8BTK5 
ID   SMYD4_MOUSE             Reviewed;         799 AA.
AC   Q8BTK5; A2BDD0; Q3U3Z8; Q501N5; Q5SWN4; Q69Z60; Q8BMP3;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 2.
DT   13-FEB-2019, entry version 120.
DE   RecName: Full=SET and MYND domain-containing protein 4;
DE            EC=2.1.1.-;
GN   Name=Smyd4; Synonyms=Kiaa1936;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, and Pituitary;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
RP   VARIANTS TYR-65; VAL-208; LYS-226; GLU-397; ALA-458; THR-486; VAL-527
RP   AND ILE-553.
RC   STRAIN=Czech II; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-799 (ISOFORM 1).
RC   TISSUE=Embryonic intestine;
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene:
RT   IV. The complete nucleotide sequences of 500 mouse KIAA-homologous
RT   cDNAs identified by screening of terminal sequences of cDNA clones
RT   randomly sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BTK5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BTK5-2; Sequence=VSP_017580;
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; AK030380; BAC26933.1; -; mRNA.
DR   EMBL; AK089959; BAC41013.1; -; mRNA.
DR   EMBL; AK154507; BAE32637.1; -; mRNA.
DR   EMBL; AL603834; CAI23978.1; -; Genomic_DNA.
DR   EMBL; AL591496; CAI23978.1; JOINED; Genomic_DNA.
DR   EMBL; AL591496; CAI35377.1; -; Genomic_DNA.
DR   EMBL; AL603834; CAI35377.1; JOINED; Genomic_DNA.
DR   EMBL; BC095952; AAH95952.1; -; mRNA.
DR   EMBL; BC130220; AAI30221.1; -; mRNA.
DR   EMBL; AK173306; BAD32584.1; -; mRNA.
DR   CCDS; CCDS48848.1; -. [Q8BTK5-1]
DR   RefSeq; NP_001096081.1; NM_001102611.1. [Q8BTK5-1]
DR   RefSeq; XP_006533600.1; XM_006533537.3. [Q8BTK5-2]
DR   UniGene; Mm.340377; -.
DR   UniGene; Mm.445425; -.
DR   ProteinModelPortal; Q8BTK5; -.
DR   SMR; Q8BTK5; -.
DR   STRING; 10090.ENSMUSP00000047505; -.
DR   iPTMnet; Q8BTK5; -.
DR   PhosphoSitePlus; Q8BTK5; -.
DR   PaxDb; Q8BTK5; -.
DR   PRIDE; Q8BTK5; -.
DR   Ensembl; ENSMUST00000044530; ENSMUSP00000047505; ENSMUSG00000018809. [Q8BTK5-1]
DR   GeneID; 319822; -.
DR   KEGG; mmu:319822; -.
DR   UCSC; uc007kdm.1; mouse. [Q8BTK5-1]
DR   CTD; 114826; -.
DR   MGI; MGI:2442796; Smyd4.
DR   eggNOG; KOG2084; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   GeneTree; ENSGT00730000111079; -.
DR   HOVERGEN; HBG082493; -.
DR   InParanoid; Q8BTK5; -.
DR   OMA; GQEILHC; -.
DR   OrthoDB; 1278034at2759; -.
DR   TreeFam; TF106441; -.
DR   PRO; PR:Q8BTK5; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000018809; Expressed in 169 organ(s), highest expression level in ureter smooth muscle.
DR   Genevisible; Q8BTK5; MM.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR002893; Znf_MYND.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF01753; zf-MYND; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
DR   PROSITE; PS50865; ZF_MYND_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Metal-binding;
KW   Methyltransferase; Polymorphism; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase; Zinc; Zinc-finger.
FT   CHAIN         1    799       SET and MYND domain-containing protein 4.
FT                                /FTId=PRO_0000227785.
FT   DOMAIN      233    570       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING     296    335       MYND-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00134}.
FT   REGION      112    114       S-adenosyl-L-methionine binding.
FT                                {ECO:0000250}.
FT   REGION      535    536       S-adenosyl-L-methionine binding.
FT                                {ECO:0000250}.
FT   BINDING     569    569       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00190}.
FT   BINDING     591    591       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00190}.
FT   VAR_SEQ       1    133       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334,
FT                                ECO:0000303|PubMed:16141072}.
FT                                /FTId=VSP_017580.
FT   VARIANT      65     65       N -> Y (in strain: Czech II).
FT                                {ECO:0000269|PubMed:15489334}.
FT   VARIANT     208    208       I -> V (in strain: Czech II).
FT                                {ECO:0000269|PubMed:15489334}.
FT   VARIANT     226    226       T -> K (in strain: Czech II).
FT                                {ECO:0000269|PubMed:15489334}.
FT   VARIANT     397    397       G -> E (in strain: Czech II).
FT                                {ECO:0000269|PubMed:15489334}.
FT   VARIANT     458    458       D -> A (in strain: Czech II).
FT                                {ECO:0000269|PubMed:15489334}.
FT   VARIANT     486    486       A -> T (in strain: Czech II).
FT                                {ECO:0000269|PubMed:15489334}.
FT   VARIANT     527    527       I -> V (in strain: Czech II).
FT                                {ECO:0000269|PubMed:15489334}.
FT   VARIANT     553    553       V -> I (in strain: Czech II).
FT                                {ECO:0000269|PubMed:15489334}.
FT   CONFLICT    363    363       V -> D (in Ref. 1; BAC26933).
FT                                {ECO:0000305}.
FT   CONFLICT    374    374       V -> I (in Ref. 1; BAC41013).
FT                                {ECO:0000305}.
FT   CONFLICT    751    751       A -> P (in Ref. 1; BAC26933).
FT                                {ECO:0000305}.
SQ   SEQUENCE   799 AA;  88538 MW;  6C4CAA5AC7B5874A CRC64;
     MDLPVDEWKS YLLKKWASLP KSVQDTISTA ETLSDIFLPS SSLLQPEDEM FLKELSSSYS
     VEKDNDAPLF YREEGNRKFQ EKEYTDAAVL YSKGVSHSRP NTEDISLCYA NRSAALFHLG
     QYEACLKDIV EAGMHGYPER LQPKMMVRKT ECLVNLGRLQ EARQTISDLE SSLTAKPTLV
     LSSYQILQRN VQHLKIKIQE KETLPEPIPA ALTNAFEDIA LGEENTQISG ASLSVSLCTH
     PLKGRHLVAT KDILPGELLV KEDAFVSVLI PGEMPRPHHC LENKWDTRVT SGDLYCHRCL
     KHTLATVPCG SCSYAKYCSQ ECMQQAWDLY HSTECSLGGL LLTLGVFCHV ALRMTLLARF
     EDVDRVVRML CDEVGSTDTC LPESKNLVKA FDYTSQGESE EKSKIGEPPI PGCNVNGKYG
     SNYNAIFSLL PHTEKHSPEH RFICAISVSA LCRQLKADSV QAQTLKSPKL KAVTPGLCAD
     LTVWGAAMLR HMLQLQCNAQ AITSICHTGS NESIITNSRQ IRLATGIFPV VSLLNHSCRP
     NTSVSFTGTV ATVRAAQRIA KGQEILHCYG PHESRMGVAE RQQRLSSQYF FDCRCGACHA
     ETLRAAAAPR WEAFCCKTCR ALMQGNDVLS CSNESCTNSV SRDQLVSRLQ DLQQQVCMAQ
     KLLRTGKPEQ AIQQLLRCRE AAESFLSAEH TVLGEIEDGL AQAHATLGNW LKSAAHVQKS
     LQVVETRHGP SSVEIGHELF KLAQVLFNGL AVPEALSAIW KAERILLVHC GPESEEVREL
     REMRSCLLDS SFVPVGPLV
//
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