GenomeNet

Database: UniProt
Entry: Q8CG65
LinkDB: Q8CG65
Original site: Q8CG65 
ID   SSPO_MOUSE              Reviewed;        4998 AA.
AC   Q8CG65; E9QMN0;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   05-JUN-2019, entry version 115.
DE   RecName: Full=SCO-spondin;
DE   Flags: Precursor;
GN   Name=Sspo;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=ICR; TISSUE=Brain;
RX   PubMed=12909363; DOI=10.1016/S0378-1119(03)00622-X;
RA   Goncalves-Mendes N., Simon-Chazottes D., Creveaux I., Meiniel A.,
RA   Guenet J.-L., Meiniel R.;
RT   "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR)
RT   superfamily expressed in the brain.";
RL   Gene 312:263-270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Involved in the modulation of neuronal aggregation. May
CC       be involved in developmental events during the formation of the
CC       central nervous system (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Subcommissural organ.
CC       {ECO:0000269|PubMed:12909363}.
CC   -!- DEVELOPMENTAL STAGE: Weakly expressed at 14 dpc and 15 dpc in the
CC       SCO anlage; increasing progressively until 17 dpc.
CC       {ECO:0000269|PubMed:12909363}.
CC   -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
DR   EMBL; AJ491857; CAD42654.1; -; mRNA.
DR   EMBL; AC153815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; Q8CG65; -.
DR   STRING; 10090.ENSMUSP00000131401; -.
DR   iPTMnet; Q8CG65; -.
DR   PhosphoSitePlus; Q8CG65; -.
DR   PaxDb; Q8CG65; -.
DR   PRIDE; Q8CG65; -.
DR   Ensembl; ENSMUST00000043676; ENSMUSP00000047991; ENSMUSG00000029797.
DR   UCSC; uc009bul.1; mouse.
DR   MGI; MGI:2674311; Sspo.
DR   eggNOG; KOG1215; Eukaryota.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; KOG3538; Eukaryota.
DR   eggNOG; KOG3611; Eukaryota.
DR   eggNOG; ENOG410XNSK; LUCA.
DR   GeneTree; ENSGT00940000155829; -.
DR   HOGENOM; HOG000154433; -.
DR   InParanoid; Q8CG65; -.
DR   Reactome; R-MMU-5173214; O-glycosylation of TSR domain-containing proteins.
DR   PRO; PR:Q8CG65; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   Bgee; ENSMUSG00000029797; Expressed in 19 organ(s), highest expression level in diencephalon.
DR   ExpressionAtlas; Q8CG65; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   CDD; cd00112; LDLa; 8.
DR   Gene3D; 2.20.100.10; -; 23.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 4.10.400.10; -; 9.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR030119; SCO-spondin.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF358; PTHR11339:SF358; 3.
DR   Pfam; PF08742; C8; 3.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF00057; Ldl_recept_a; 7.
DR   Pfam; PF01826; TIL; 13.
DR   Pfam; PF00090; TSP_1; 22.
DR   Pfam; PF00093; VWC; 1.
DR   Pfam; PF00094; VWD; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00832; C8; 3.
DR   SMART; SM00192; LDLa; 10.
DR   SMART; SM00209; TSP1; 25.
DR   SMART; SM00214; VWC; 4.
DR   SMART; SM00215; VWC_out; 9.
DR   SMART; SM00216; VWD; 2.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF57424; SSF57424; 9.
DR   SUPFAM; SSF57567; SSF57567; 14.
DR   SUPFAM; SSF82895; SSF82895; 24.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS01209; LDLRA_1; 8.
DR   PROSITE; PS50068; LDLRA_2; 10.
DR   PROSITE; PS50092; TSP1; 25.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 2.
DR   PROSITE; PS51233; VWFD; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Complete proteome; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL        1     17       {ECO:0000255}.
FT   CHAIN        18   4998       SCO-spondin.
FT                                /FTId=PRO_0000245043.
FT   DOMAIN       18    102       EMI.
FT   DOMAIN      163    288       VWFD 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      349    404       TIL 1. {ECO:0000255}.
FT   DOMAIN      404    496       VWFC 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      443    652       VWFD 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      706    759       TIL 2. {ECO:0000255}.
FT   DOMAIN      893   1097       VWFD 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN     1153   1209       TIL 3. {ECO:0000255}.
FT   DOMAIN     1253   1290       LDL-receptor class A 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1293   1328       LDL-receptor class A 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1329   1365       LDL-receptor class A 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1369   1407       LDL-receptor class A 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1442   1478       LDL-receptor class A 5.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1480   1519       LDL-receptor class A 6.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1533   1571       LDL-receptor class A 7.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1572   1626       TSP type-1 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1628   1686       TSP type-1 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1692   1746       TIL 4. {ECO:0000255}.
FT   DOMAIN     1702   1741       EGF-like 1.
FT   DOMAIN     1742   1768       EGF-like 2.
FT   DOMAIN     1771   1827       TSP type-1 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1827   1887       VWFC 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     1929   2085       F5/8 type C. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00081}.
FT   DOMAIN     2091   2127       LDL-receptor class A 8.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2242   2278       LDL-receptor class A 9.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2299   2335       LDL-receptor class A 10.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2336   2389       TSP type-1 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2391   2446       TSP type-1 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2468   2511       TIL 5. {ECO:0000255}.
FT   DOMAIN     2551   2605       TSP type-1 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2609   2664       TSP type-1 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2666   2719       TSP type-1 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2820   2875       TSP type-1 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2876   2919       TSP type-1 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2926   2978       TIL 6. {ECO:0000255}.
FT   DOMAIN     3019   3086       TSP type-1 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3088   3143       TSP type-1 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3151   3201       TIL 7. {ECO:0000255}.
FT   DOMAIN     3244   3306       TSP type-1 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3308   3363       TSP type-1 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3365   3421       TIL 8. {ECO:0000255}.
FT   DOMAIN     3481   3529       TSP type-1 15. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3657   3713       TSP type-1 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3727   3779       TSP type-1 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3793   3849       TSP type-1 18. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3851   3906       TSP type-1 19. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3909   3964       TIL 9. {ECO:0000255}.
FT   DOMAIN     4006   4059       TSP type-1 20. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4100   4155       TSP type-1 21. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4157   4213       TSP type-1 22. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4215   4269       TSP type-1 23. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4273   4328       TIL 10. {ECO:0000255}.
FT   DOMAIN     4465   4516       TSP type-1 24. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4530   4576       TIL 11. {ECO:0000255}.
FT   DOMAIN     4616   4669       TSP type-1 25. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4671   4725       TIL 12. {ECO:0000255}.
FT   DOMAIN     4777   4835       TIL 13. {ECO:0000255}.
FT   DOMAIN     4835   4893       VWFC 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     4892   4991       CTCK. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00039}.
FT   CARBOHYD     88     88       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    130    130       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    534    534       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    698    698       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    771    771       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    790    790       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    824    824       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    866    866       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1230   1230       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1528   1528       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1598   1598       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1687   1687       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1892   1892       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1989   1989       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2481   2481       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2530   2530       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2772   2772       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2802   2802       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2897   2897       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2952   2952       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2999   2999       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3009   3009       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3146   3146       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3235   3235       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3301   3301       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3357   3357       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3435   3435       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3462   3462       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3638   3638       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3761   3761       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3986   3986       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4196   4196       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4267   4267       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4408   4408       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4463   4463       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4584   4584       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4601   4601       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4606   4606       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4716   4716       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4756   4756       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4799   4799       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4806   4806       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4912   4912       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID   1254   1267       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1261   1280       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1274   1289       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1294   1306       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1301   1319       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1313   1328       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1330   1342       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1337   1355       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1349   1364       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1370   1382       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1377   1395       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1389   1406       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1443   1455       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1450   1468       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1462   1477       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1481   1494       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1488   1507       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1501   1518       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1534   1544       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1539   1557       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1551   1572       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1584   1620       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1588   1625       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1599   1610       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1640   1680       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1644   1685       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1654   1664       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1772   1811       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1783   1787       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   1821   1826       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2092   2104       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2099   2117       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2111   2126       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2243   2255       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2250   2268       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2262   2277       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2300   2312       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2307   2325       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2319   2334       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2337   2373       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2348   2352       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2383   2388       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2403   2440       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2407   2445       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2418   2430       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2552   2590       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2563   2567       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2600   2604       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2620   2658       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2624   2663       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2640   2648       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2678   2713       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2682   2718       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2693   2703       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2821   2859       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2832   2836       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   2869   2874       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3031   3080       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3035   3085       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3046   3070       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3100   3137       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3104   3142       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3115   3127       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3256   3299       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3260   3305       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3271   3283       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3320   3355       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3323   3362       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3333   3345       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3493   3523       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3497   3528       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3508   3513       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3669   3707       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3673   3712       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3685   3697       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3794   3830       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3805   3809       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3843   3848       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3863   3900       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3867   3905       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   3878   3890       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4007   4043       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4018   4022       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4053   4058       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4112   4149       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4116   4154       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4127   4139       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4169   4207       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4173   4212       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4184   4195       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4216   4253       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4227   4229       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4263   4268       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4466   4500       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4477   4481       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4510   4515       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4628   4663       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4632   4668       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4643   4652       {ECO:0000255|PROSITE-ProRule:PRU00210}.
FT   DISULFID   4892   4952       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   4918   4969       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   4928   4985       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   DISULFID   4932   4987       {ECO:0000255|PROSITE-ProRule:PRU00039}.
FT   CONFLICT    192    192       H -> Q (in Ref. 1; CAD42654).
FT                                {ECO:0000305}.
FT   CONFLICT   1043   1043       V -> L (in Ref. 1; CAD42654).
FT                                {ECO:0000305}.
FT   CONFLICT   1049   1049       E -> Y (in Ref. 1; CAD42654).
FT                                {ECO:0000305}.
FT   CONFLICT   1071   1071       V -> W (in Ref. 1; CAD42654).
FT                                {ECO:0000305}.
FT   CONFLICT   1080   1080       R -> P (in Ref. 1; CAD42654).
FT                                {ECO:0000305}.
FT   CONFLICT   1769   1769       F -> G (in Ref. 1; CAD42654).
FT                                {ECO:0000305}.
FT   CONFLICT   3379   3379       P -> R (in Ref. 1; CAD42654).
FT                                {ECO:0000305}.
FT   CONFLICT   3412   3412       D -> H (in Ref. 1; CAD42654).
FT                                {ECO:0000305}.
SQ   SEQUENCE   4998 AA;  534975 MW;  52726F62E3639AEC CRC64;
     MLPLALLFGM LWTQANGHWC EQIETVHVEE EVTPRQEDLV PCTSLYHYSR LGWQLDLSWS
     GRVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG AHCTDALAET SPKGHCFVTW
     HCQPLAGSAN SSAGSLEDPA DELGVWPLTL NDPILFPGMS LQWQGDWLVL SGGLGVVVRL
     DRSSSISISV DHEFWGRTQG LCGLYNGRPE DDFVEPGGGL ATLAATFGNS WKLPGSEPGC
     LDAVEVAWGC ESLLGGTLTD LEAVKLQAQA QDMCHQLLEG PFWQCHGQVQ PDEYHETCLF
     AYCVGATAGN GPEGQLEAVC ATFANYAQAC ARQHIYVHWR KPGFCERVCP GGQLYSDCVS
     SCPPSCSAVA QGEEGSCGKE CVSGCECPTG LFWDGALCVP AAHCPCYHRR QRYAPGDTVK
     QQCNPCVCQD GRWHCAQALC PAECAVGGDG HYFTFDGRSF FFRGTPGCHY SLVQDSVKGQ
     LLVVLEHGAC DTGSCLHALS VFLGNTHIQL RYSGAVLVDG EDVDLPWIGV EGFNISWASS
     TFLLLHWPGA WVLWGVAEPA AYITLDPRHA YQVQGLCGTF TWKQQDDFLT PAGDIETSVT
     AFASKFQVSG DGRCPLVDKS PLFCSSYSQH LTFTEAACAI LHGHAFQECH GLVDREPFRL
     RCLEAVCGCA PGRDCLCPVL SAYTRHCAQE GVLLQWRNET LCPVSCPGGQ VYQECAPVCG
     HHCGEPEDCK ELGICVAGCN CPPGLLWDLE GQCVPPSMCH CQFGGHRYTI NTTTVRDCSH
     CICQERGLWN CTAHHCPRQW ALCPRELIYV PGACLLTCDS PRANHSCWAG STDGCVCPPG
     TVLLDKHCVS PDLCPCRHNG QWYPPNATIQ EDCNICVCQG QRWHCTGQRC SGWCQASGAP
     HYVTFDGLVF TFPGACEYLL VREAGGRFSV SVQNLPCGAS GLTCTKALVV RLDSTVVHML
     RGQAVTVNGV SIRLPKVYTG PGLSLHHAGL FLLLTTRLGL TLLWDGGTRV LVQLSPHFHG
     RVAGLCGNFD SDASNDLRSR QGVLEPTAEL TAHSWRLNPL CPEPGDLPHP VNAHRANWAR
     ARCEVILQPI FAPCHTEVPP QQYYEWCVYD ACGCDTGGDC ECLCSAIATY ADECARHRHH
     VRWRSQELCP LQCEGGQVYE PCGSTCPPTC HDHHSELRWH CQVITCVEGC FCPEGTLLHG
     GACMKLAACP CEWQGSFFPP GTVLQKDCGN CTCQGSQWHC DRGGAPCEDM EPGCAEGETL
     CRENGHCVPL EWLCDNQDDC GDGSDEEGCA TSVCGEGQMS CQSGHCLPLS LICDGQDDCG
     DGTDEQGCLC PHGSLACADG RCLPPALLCN GHPDCLDAAD EESCLGPVSC ISGEVSCVDG
     TCVRTIQLCD GVWDCPDGAD EGPSHCSLPS LPTPPGGIGQ NPSTSSLDTA PSPVGSTSPA
     SPCSLLEFQC NSGECTPRGW RCDQEEDCTD GSDELDCGGP CMLYQVPCAH SPHCVSPGQL
     CDGVTQCPDG SDEDPDVCEE QSASGGANRT GAPCPEFSCP DGTCIDFLLV CDGNPDCELA
     DETEPSLDEQ GCGAWGSWGP WAPCSQTCGS GTRSRNRNCS TSSLQVLQNC PGLQHQSQAC
     FTEACPVDGE WSSWSPWSPC SEPCGGTTTR HRQCRPPQNG GQDCALLPGS THSTRQTSPC
     PQEGCLNATC FGELVFRTCA PCPLTCDDIS GQAACPPDRP CSSPGCWCPD GKVLNTEGQC
     VRPRQCPCLV DGAHYWPGQR IKMDCQLCFL DCGWSSWSPW AECLGPCSSQ SLQWSFRSPN
     NPRLSGHGRQ CRGIHRKARR CQTEACEGCE QWGLMYNVGE RWRGGPCMVC ECLHSSITHC
     SPYCPIGSCP QGWVLVEGMG ESCCHCALPE KNQTVIHMTT PAPAPASAPS PQIGAHLVTY
     VLPPTADACY SPLGLAGLPM WAPSQHWEHI TRADPVEAPM AGPGPREGAS AEWHTQPLYL
     QLDLRRPRNL TGIIVQRAGS SAAYVSTLSL QFSSDNLQWH NYVNSLSSTL SPPKPSPESS
     NHMAPEVWTF DQMVQARYIR VWPHSGHLRD NNQHDIFLWV ELLGLSPLAP LCPGSRHRCA
     SGECAPKGGP CDGAVDCDDG SDEEGCGSLH ASTTSRTPAL SPTQPGKFPR EVSEDLRQGA
     EAMTSHSPPS SGETAGLIPA SEGTLPVSGQ PMQTLSATST FPPGAKSLHP GMAAVTVHPP
     HSVTPGAPVG QTVSPRPFPP MPCGPGQVPC DVLGCVEQEQ LCDGREDCLD GSDEQHCASA
     EPFTVPTTAL PGLPASKALC SPSQLRCGSG ECLPFEHRCD LQVNCQDGSD EDNCVDCVLA
     PWSGWSDCSR SCGLGLIFQH RELLRLPLPG GSCLLDQFRS QSCFVQACPV AGAWAEWGPW
     TACSVSCGGG HQSRQRSCVD PPPKNGGAPC PGPSHEKAPC NLQLCPGDTD CEPGLVHVNA
     ELCQKGLVPP CPPSCLDPEA NRSCSGHCME GCRCPPGLLL QDSHCLPLSE CPCLVGQKLI
     QPRLAFLLDN CSQCICEKGT LLCKPGACSQ SCGWSAWSPW TACDRSCGSG VRARFRSPTN
     PPVAFGGSPC EGDRQELQAC YTDCGTEIPG WTPWTSWSSC SQSCLVPGGD PGWRQRSRLC
     PSSRDTFCPG EATQEEPCSP PVCPVPSAWG LWASWSTCSA SCNGGIQTRG RSCSGSAPGN
     PVCLGPHTQT RDCNMHPCTA QCPGNMVFRS AEQCLEEGGP CPQLCLAQDP GVECTGSCAP
     SCNCPPGLFL HNASCLPRSQ CPCQLHGQLY APGAVAHLDC NNCTCISGEM VCTSKRCPVA
     CGWSPWTPWS PCSQSCNVGI RRRFRAGTEP PAAFGGAECQ GPNLDAEFCS LRPCRGPGAA
     WSSWTPCSVP CGGGYRNRTQ GSGPHSPIEF STCSLQPCAG PVPGVCPEDQ QWLDCAQGPA
     SCAHLSIPGE ANQTCHPGCY CLSGMLLLNN VCVPVQDCPC AHRGRLYSPG SAVHLPCENC
     SCISGLITNC SSWPCEEGQP AWSSWTPWSV CSASCNPARR HRHRFCARPP HRAPFSLVLL
     TTVAAPTTLC PGPEAEEEPC LLPGCNQAGG WSPWSPWSGC SRSCGGGLRS RTRACDQPSP
     QGLGDFCEGP QAQGEACQAQ PCPVTNCSAM EGAEYSPCGP PCPRSCDDLV HCVWRCQPGC
     YCPLGKVLSA DGAICVKPSY CSCLDLLTGK RHHAGTQLMR PDGCNHCTCM EGRLNCTDLP
     CQVSGDWCPW SKWTACSQPC RGQTRTRSRA CVCPAPQHGG SPCPEESGGT GVQHQMEACP
     NATACPVDGA WSPWGPWSSC DACLGQSYRS RVCSHPPISD GGKPCLGGYQ QSRPCRNSST
     LCTDCGGGQD LLPCGQPCPH SCQDLSLGST CQPGSAGCQS GCGCPPGQLS QDGLCVFPVD
     CHCHFQPRAM GIPENRSRSV GSTLSSWESL EPGEVVTGPC DNCTCVAGIL QCHEVPSCPG
     PGIWSSWGPW EKCSVSCGGG EQLRSRQCAR PPCPGLAQQS RICHIHVCRE TGCPAGRLYR
     ECQPSDGCPF SCAHVTGQVA CFSERCKEGC HCPEGTFQHH VACVQECPCV LTVLLLQELG
     LASAALGSYP TLLGDEGKPL GPGVELLPGQ MLQTDCGNCS CVHGKLSCSM VECSRVHGSF
     GPWGMWSLCS RSCGGLGTRT RTRQCVLPTL APGGLSCRGP LQDLEYCFSP ECPGTAGSTV
     EPVTGLAGGW GPWSPWSPCS HSCTDPAHPA WRSRTRLCLA NCTVGDSSQE RPCNLPSCAA
     LLPCPGPGCG SGNCFWTSWA PWEPCSRSCG VGQQRRLRAY HPPGPGGHWC PDILTAYQER
     RFCNLRACPV PGGWSHWSPW SWCDRSCGGG RSLRSRSCSS PPPKNGGTSC VGERHHVRPC
     NPMPCEEGCP AGMEMVSCAN HCPYSCSDLQ EGGMCQEDQA CQLGCRCSEG FLEQDGGCVP
     VGHCECTDAQ GRSWAPGSQH QDACNNCSCQ AGQLSCTAQL CSPPAHCAWS HWSAWSSCSH
     SCGPQGQQSR FRSSTSGSWA LECQKEQSQS QPCPEVPCPP LCLHEAHLHE LGDNWLHGEC
     QQCSCTPEGA ICKDTDCAVP RGWTLWSSWS YCSVSCGGGS QVRTRSCTVS APPHGSLSCE
     GPDTQTRHCG QQLCLQKLER CSWGPWGPCS RSCGTGLASR SGSCPCLLTK EDSKCNDTFL
     GLDTQACYSG PCQDDCTWGD WSSWTRCSCK VLVQQRYRHQ VPAPGQAGEG TPCTRLDGHF
     RPCTIGNCSE DSCPPPFEFQ SCGSPCAGLC ATHLNHRLCQ DLPPCQPGCY CPKGLLEQAG
     SCILPEQCNC WHISGEGARV TLAPGDRLQL GCKECVCRRG ELQCSSQGCE GLLPLTGWSE
     WSPCGPCLPQ SALAPASRTA LEGHWPLNTS DLPPPSVTLL ASEQYRHRLC LDPETRRPWA
     GDPALCTVPL SQQRLCPDPG ACNDTCQWGP WGPWSPCQMP CSGGFKLRWR VARDTSAGEC
     PGPWAQTESC NMGSCPGESC ETRDTVFTLD CANQCPRSCA DLWDGVQCLQ GPCSPGCRCP
     PGQLVQDGHC VPISSCRCGL PSANASWELA PTQVVQLDCH NCTCINGTLM CPHLECPVLG
     PWSAWSECSA VCGKGTMVRH RSCEEHPDRE PCQALDLQQW QECNLQACPE CPPGQVLSTC
     ATMCPSLCSH LWPGTICVRE PCQLGCGCPG GQLLYNGTCI PPEACPCTQF SLPWGLTLPL
     EEQARELPSG TVLTRNCTHC TCQGGAFICS LTDCQECAPG EIWQHGKLGP CEKTCPEMNM
     TQAWSNCTEA QAPGCVCQLG YFRSQTGLCV PEDHCECWHH GSPHLPGSEW QEACESCRCL
     HGKSVCIRHC PELSCAQGEV IMQEPGSCCP ICQQDTLKEE PVSCRYLTEL RNLTKGPCHL
     DQIEVSYCSG HCRSSTNVMT EEPYLQSQCD CCSYRLDPDS PVRILNLLCP DGHTEPVVLP
     VIHSCQCSAC QGGDFSKH
//
DBGET integrated database retrieval system