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Database: UniProt
Entry: Q8CJN6_STRCO
LinkDB: Q8CJN6_STRCO
Original site: Q8CJN6_STRCO 
ID   Q8CJN6_STRCO            Unreviewed;      4557 AA.
AC   Q8CJN6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   23-MAY-2018, entry version 116.
DE   SubName: Full=Putative type I polyketide synthase {ECO:0000313|EMBL:CAD55506.1};
GN   OrderedLocusNames=SCO6275 {ECO:0000313|EMBL:CAD55506.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAD55506.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145
RC   {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.H., Kieser T., Larke L., Murphy L., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
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DR   EMBL; AL939127; CAD55506.1; -; Genomic_DNA.
DR   RefSeq; NP_733695.1; NC_003888.3.
DR   RefSeq; WP_011030787.1; NC_003888.3.
DR   ProteinModelPortal; Q8CJN6; -.
DR   STRING; 100226.SCO6275; -.
DR   EnsemblBacteria; CAD55506; CAD55506; CAD55506.
DR   GeneID; 1101716; -.
DR   KEGG; sco:SCO6275; -.
DR   PATRIC; fig|100226.15.peg.6391; -.
DR   eggNOG; ENOG4107GJR; Bacteria.
DR   eggNOG; COG3321; LUCA.
DR   HOGENOM; HOG000046292; -.
DR   InParanoid; Q8CJN6; -.
DR   OMA; PKHLNFE; -.
DR   OrthoDB; POG091H06Z6; -.
DR   BioCyc; MetaCyc:SCO6275-MONOMER; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 3.
DR   Gene3D; 3.40.366.10; -; 3.
DR   Gene3D; 3.40.47.10; -; 3.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 3.
DR   Pfam; PF16197; KAsynt_C_assoc; 3.
DR   Pfam; PF00109; ketoacyl-synt; 3.
DR   Pfam; PF02801; Ketoacyl-synt_C; 3.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF14765; PS-DH; 2.
DR   SMART; SM00827; PKS_AT; 3.
DR   SMART; SM00826; PKS_DH; 2.
DR   SMART; SM00825; PKS_KS; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   SUPFAM; SSF47336; SSF47336; 3.
DR   SUPFAM; SSF51735; SSF51735; 4.
DR   SUPFAM; SSF52151; SSF52151; 6.
DR   SUPFAM; SSF53901; SSF53901; 3.
DR   SUPFAM; SSF55048; SSF55048; 3.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 2.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001973};
KW   Phosphopantetheine {ECO:0000256|PROSITE-ProRule:PRU00258};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT   DOMAIN      920    995       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2657   2732       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     4403   4478       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES     955    955       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
FT   MOD_RES    2692   2692       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
FT   MOD_RES    4438   4438       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   4557 AA;  476022 MW;  0BA04B4B03DC4E18 CRC64;
     MVTSENNSVA AGAHTGQVER IAVVGLSCRL PGAADPAAFW ELLHSGSDAV TEVPPGRWDV
     PADAAPGSGS GGRRGAFLDG VDRFDAGFFG ISPREAAAMD PQQRLVLELT WEALEDAAIV
     PASLRGSRTA VFVGTLRDDY TNLLYQYGDE AVTQHTMAGV NRGVIAGRVS YHLGLRGPSL
     TVDSAQSSSL VAVHLACESL RSGESTTAVV AGVNLNLLAE NATTEERFGA LSPDGVSYTF
     DARANGFVPG EGGGVVVLKP LSAALADGNR IHGVIRGTAV NNDGAADGLT VPSGTAQEQL
     IREAHRRSAL GPGERVQYVE LHGTGTPVGD PVEAAALGAA LGAERGDADG PLRVGSVKTN
     IGHLEGAAGM AGLIKTLLAI THRELPASLN FRTANPAIPL AELGLEVQRE LSAWPRPDRP
     LVAGVSSFGM GGTNAHVVVG EPPLPAAEPD TLTGSAAPSS LSWVVTANSE EALRGQAARL
     AEFAGAENAP DPRDTGYSLA TDRTVFEHRA VVVGADGAAL LDGVRALAEG RPGAGVVRGR
     GEAGATALLF TGQGAQRPGM GQELYAAHPV FADAFDAVAE RLDPMLKQPL WEVIASGEGL
     DETGRTQPAL FAIEVALFRL LESWGVRPGF LAGHSIGELA AAHVAGVLSL DDAARLVAAR
     ARLMQALPAG GAMIAVEATE EEVLPHLEGL EARLSLAAVN GPASVVISGE ADAAEDVAAR
     LAEAGRRTKR LTVSHAFHSP LMDGMLKEFH KVAKELTYHA PRIPVVSTLT GALASGDDLR
     TPCYWTDQVR HAVRFADAVR TLGELGATVL LEVGPDAVLS SLADATPTLR AGRPETRTLL
     TAVATAFVRG ADVDWRAVHA DAGGRSVPLP TYAFQRRRHW FDAAARKETR AIAPAADEVR
     SPAAASGVPS VPAGRAERLR YAEDLVTSHV TAVLEYGDGE RLDPRVPFQK LGFTSLMTTE
     LRAALAEATG LALPGSLLFD HPTPRELTAF LATRLADTTD EPEAGEEFIR PADAGEPIAI
     VGMACRFPGG ITSPAQLWKL VSEGGDAITE FPVNRGWPDD LYDADPDRPG RSAVRHGGFL
     HDAGEFDADF FGISPREALA MDPQQRLLLE SAWEAVERAG IDPDTLRGSR TGVFVGATAL
     EYGPRMHEAP ESVQGSVLTG STTSVMSGRI AYQLGLLGPA VTTDTACSSS LVALHLAIRS
     LRSGETSLAL AGGATVMSSP GMFVEFSRQR GLAPDGRCKS FAAGADGTGW SEGVGLLLVE
     RLSDARRNGH QVLAVVRGSA VNQDGASNGL TAPNGLSQQR VVRQALADSG LAATEVDAVE
     AHGTGTRLGD PIEAEALMAT YGTGRDGLPP VYLGSLKSNI GHAQAAAGVG GVIKMVEAIR
     HGVLPRTLHV DEPSPRVDWN AGALELLTGE RAWPDTGRPR RAAVSSFGIS GTNAHVVLEQ
     APDAPPPSAA PPATQAPAVP APWLLSARDP DTLRAQAERL RAYADGDRAP EPAAIGRALA
     TTRTAFEQRA VVLAEDRAGY LAGLDALIRG ADAPGVVTGS ARSAGRTAFL FTGQGAQRAG
     MGRELYARHP VFAEALDAAF GALDAHLDLP LREVVFAAEG SREAALLDET TYTQPALFAL
     EVALFRLLEH HGVTPGLLAG HSVGELSAAH AAGVLTLDDA AKLVAARGRL MQAARSGGAM
     IAVEAAEEEV LPYLEGRAAG LSVAAVNGPA SVVISGDEEP ALEVAELLRA SGRRTKRLTV
     SHAFHSPHMD GVLDAFREVA STVAFSAPTV PIVSTVTGRL ATEAELTSPQ YWANQIRAAV
     RFLDAARELA AQGATVFVEA GPDAVLTALT RAALEDTGAT AVPLMRAGRP EAETLTLGLG
     GAHAAGAALD AATFFPGAAT ADGLPTYAFR RTHYWLAPAS PTDARSLGLD ASEHPLLSTS
     VELAGREDTL FTGRLSLSGH PWLADHTIGS AVLVPATAFV ELAMAAGDHL GAGRVADLTL
     EAPLPLTGRD AVRVQVAVGA PDASGLRPFS VHARPDTGDD GTDRPWTRHV SGALATEAEA
     AVPEPDPVFG VWPPEGAAAE PLDGVYDRLA ALGYHYGPAF QGLRALWRHG EDLYAEVRLP
     EEHREAAAGF GVHPALFDAV LHPLVLDAGA DGDSGRIRLP FAWSGVVLHA TGATGLRIRI
     SPGGPDTYRI SMADDTGAPV AGVESLTLRP VDARRLAADA DAAPAAALHT VEWAPVPLPA
     GAGPDWAEAA DGLDAAAGSA IVVVRPPGAP DTAEGAHQPV RDALEVVQRW LADERFAEGR
     LAFVTRGAVA ALPGDDVTGL AAAPVWGLIR SVQSEHPDRV VLVDLDGDDD RLLPAALAAG
     EPQLAVRGGK LYAPRLARRD PAPGRNAPTP ALDGTVLVTG GTGGLGALVA RHLVTEHGVR
     HLLLSSRRGP GTPGADALRS ELTALGAEVT VVAADAADRN AVAGLLAAVD ARHPLSAVVH
     TAGVLDDATA QSLTPEQLAT VLRPKVDAAR HLHELTKDLD LAAFVLFSSV SGITGTAGQA
     NYAAANTYLD ALAAHRRASG LPATSLAWGL WDASHGMGGT LGEADLARWA RAGMTPLTPK
     QGLTLFDTAL TGTEPLLVPV ALDLARFRTG AEPLPALLRG LVRTRARRAV QAGAGTGGAG
     SDWARRIAAL PEDKRRDAVL GLVRDTVAAI LGHAGGTSVD PERAFNDIGF DSMAGVDLRN
     RLGAATGLRL PATVVFDHPT PGAVAAHLLS RVSESSRPAD APTAARRRGP ADEPIAIVGM
     ACRYPGGVSS PEELWRLVAD GVDAVTEFPV NRGWDLENLY DPDPEQTGTS YVREGGFLHD
     ADLFDREFFG ISPREATATD PQQRLLLETA WETFENAGLD PALLRGSNTG VFTGAMYDDY
     ASRLASAPEE FEGFLLAGNL SSVVSGRLSY TYGLEGPAVT VDTACSSSLV ALHMAAGALR
     SGECDLALAG GVTVMNGPST FVEFSRQRGL SPDGRCKSFA AGADGTGWSE GVGLLLVERL
     SDARRNGHQV LAVVRGSAVN QDGASNGLTA PNGPSQERVI RQALANADLT PADIDAVEAH
     GTGTTLGDPI EAQALLATYG QDRAEGRPLY LGSLKSNIGH SQAAAGVGGI IKMIEAMRHG
     VLPRTLHVDA PSPHVDWETG TLALLTEETP WPAAGRPRRA GVSSFGISGT NAHVIVEEAP
     AAPVDRRPAA GPESSGGVVP WIVSGKDEAA LRAQARRLHQ YVLDHPDLSP ADIGHSLATT
     RAVLDQGAAV VGADRESLLR GLAAIERGES AGVVRARSAR PGKTAFLFTG QGSQRLGMGR
     ELYESSPVFA KALDEVCSRF RAELARPVKD VLFAQEDSAT AALIDQTAFT QAALFCVEVA
     LYRLFEHHGF TPDYLLGHSI GEVTAAYLSG VLDLDDACCL VAERGRLMQA AREGGAMAAL
     QASEEEVYAS IAPYGDAVGI AGVNGPESLV ISGDEDVVEE VTAAWRANGV RTKRLPVSHA
     FHSSHMDEVL DEFREVASGL SFRPPRIPVV SNVTGTLATD AQLTSPDYWA THIREAVRFL
     DGVRYLEAQG VTDFLELGPD AVLTALTRGS LEEEAGVLVA ALRRDRPEAE TVAAAIAALR
     LRGAAPAWDT VFPGARRVAL PTYAFQHERY WLDAPETSTD AAGLGLSAAG HPLLGAAVRM
     AHRDEYLFTG RLSRHSQPWL TEHAVHGTVL VPATGLLELA VRVGGQLGAE RVEELMLSAP
     LVLPEQGGVQ VQLVVGEADG AGRRTVEVFS RLDDGDVTAD RPWTLHASGA LAPAAGVLGE
     PPLPWPPAGA GEVPLDGVYD RLTDVGYAYG PAFQGLRRVW RGDGEIYAEV ALPEEQRADA
     GRYVLHPALL DAALHPLLPG VADQDRAALL PFTWSGVTIH ATGASVLRVR LTLTGPDVAA
     LTVTDATGAP VASVESLLLR PLSKDALRQA ASTARDGLFR IAWNTLPTTD TPTDTTGWAV
     VGDLTVDGAT RHTNLDAVRA EDNIPRTVLY APPVPDGDVP EAAHAALRDA LSTTQSWLAD
     DRTTDTTLVV VTRGALATRE GQHTDPVQAG LWGLLRVAQT ENPGRIALLD TDTDTIPTTA
     LTTDEPQLAL RDNTFHTPRL ARTTDQPTDQ PTDRPRWDRG TVLITGATGA LGTVLARHLV
     TQHGTRHLLL LSRRGTNAPG AQELQHELTA LGATVTITAC DAADRHALTS VLDDIPAEHP
     LTAVVHTAGV LDDTVLADLT AERLEKVLRP KVDAAWNLHE LTKDHDLEAF VLYSSIAGLI
     GNAGQANYAA GNTFLDALAQ HRRALGLPAV SLAWGLWAQA STISGQLDQT DLRRLARLGL
     LPLSSADAMD LFDAAPATGE AVLAATRLDL GTLRKQGAHL LPLLRDLVPA APRRAAADTG
     GTEGGPSLAE RLGALPDEEQ RVEALTDLVR VQVAAVLGHS DPGSVDPGRA FQELGFDSLT
     AVELRNQLST VSGLRLPTTL VFDHPSPAAL AAHLRQRITV EEGAAATPVL ADLDRLKSAI
     RSASVDRDAF DRITGRLREL LDVADTANGS AAGDDDTDRD LDTASDEELF ALLDDLG
//
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