GenomeNet

Database: UniProt
Entry: Q8CK11
LinkDB: Q8CK11
Original site: Q8CK11 
ID   UVRB_STRCO              Reviewed;         712 AA.
AC   Q8CK11;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   31-JUL-2019, entry version 99.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204};
GN   OrderedLocusNames=SCO1966; ORFNames=SC3C9.01c, SCC54.26c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
DR   EMBL; AL939111; CAD55287.1; -; Genomic_DNA.
DR   PIR; T36039; T36039.
DR   RefSeq; NP_733553.1; NC_003888.3.
DR   RefSeq; WP_011028069.1; NC_003888.3.
DR   SMR; Q8CK11; -.
DR   STRING; 100226.SCO1966; -.
DR   EnsemblBacteria; CAD55287; CAD55287; CAD55287.
DR   GeneID; 1097400; -.
DR   KEGG; sco:SCO1966; -.
DR   PATRIC; fig|100226.15.peg.1992; -.
DR   eggNOG; ENOG4105CCW; Bacteria.
DR   eggNOG; COG0556; LUCA.
DR   HOGENOM; HOG000073580; -.
DR   InParanoid; Q8CK11; -.
DR   KO; K03702; -.
DR   OMA; RYMHSEI; -.
DR   PhylomeDB; Q8CK11; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR041471; UvrB_inter.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome;
KW   SOS response.
FT   CHAIN         1    712       UvrABC system protein B.
FT                                /FTId=PRO_0000227372.
FT   DOMAIN       35    421       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      438    604       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      667    702       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      48     55       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF       101    124       Beta-hairpin.
SQ   SEQUENCE   712 AA;  80028 MW;  C93927DC3B715A97 CRC64;
     MRPVSQIERT VAPFEVVSPY QPSGDQPTAI AELARRVQAG EKDVVLLGAT GTGKSATTAW
     MIEKLQRPTL VMAPNKTLAA QLANEFRELL PNNAVEYFVS YYDYYQPEAY VPQSDTYIEK
     DSSINEEVER LRHSATNSLL TRRDVIVVAS VSCIYGLGTP QEYVDRMVPL RVGEEHDRDE
     LLRRFVDIQY TRNDMAFARG TFRVRGDTIE IFPVYEELAV RIEMFGDEIE ALSTLHPVTG
     EIISEDQQLY VFPASHYVAG PERLERAVND IEKELAERLT ELEKQGKLLE AQRLRMRTTY
     DIEMLRQIGS CSGVENYSMH FDGRSPGSPP NTLLDYFPDD FLLVIDESHV TVPQIGAMYE
     GDASRKRTLV DHGFRLPSAL DNRPLKWEEF QERIGQTVYL SATPGAYELS RSDGAVEQII
     RPTGLVDPEV VVKPTEGQID DLVHEIRRRT EKDERVLVTT LTKKMAEDLT DYFVELGIQV
     RYLHSDVDTL RRVELLRELR AGEYDVLVGI NLLREGLDLP EVSLVAILDA DKEGFLRSGT
     SLIQTIGRAA RNVSGQVHMY ADKITPAMEK AIDETNRRRE KQVAFNKANG VDPQPLRKKI
     NDIVAQIARE DVDTEQLLGS GYRQTKEGKG AKAPVPALGG QKTGGAKAAR GRAKETAVTD
     RPAAELAEQI EDLTTRMRAA AADLQFEIAA RLRDEVSEMK KELRQMREAG LA
//
DBGET integrated database retrieval system