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Database: UniProt
Entry: Q8CNB8
LinkDB: Q8CNB8
Original site: Q8CNB8 
ID   Y1879_STAES             Reviewed;         317 AA.
AC   Q8CNB8;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   23-MAY-2018, entry version 95.
DE   RecName: Full=Putative 2-hydroxyacid dehydrogenase SE_1879;
DE            EC=1.1.1.-;
GN   OrderedLocusNames=SE_1879;
OS   Staphylococcus epidermidis (strain ATCC 12228).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J.,
RA   Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z.,
RA   Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; AE015929; AAO05520.1; -; Genomic_DNA.
DR   RefSeq; NP_765434.1; NC_004461.1.
DR   RefSeq; WP_002477137.1; NC_004461.1.
DR   ProteinModelPortal; Q8CNB8; -.
DR   SMR; Q8CNB8; -.
DR   STRING; 176280.SE1879; -.
DR   EnsemblBacteria; AAO05520; AAO05520; SE_1879.
DR   GeneID; 1055750; -.
DR   KEGG; sep:SE1879; -.
DR   PATRIC; fig|176280.10.peg.1836; -.
DR   eggNOG; ENOG4105C5I; Bacteria.
DR   eggNOG; COG1052; LUCA.
DR   OMA; KWIAHNG; -.
DR   BioCyc; SEPI176280:G1G05-1938-MONOMER; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    317       Putative 2-hydroxyacid dehydrogenase
FT                                SE_1879.
FT                                /FTId=PRO_0000312190.
FT   NP_BIND     155    156       NAD. {ECO:0000250}.
FT   NP_BIND     234    236       NAD. {ECO:0000250}.
FT   NP_BIND     283    286       NAD. {ECO:0000250}.
FT   ACT_SITE    236    236       {ECO:0000250}.
FT   ACT_SITE    265    265       {ECO:0000250}.
FT   ACT_SITE    283    283       Proton donor. {ECO:0000250}.
FT   BINDING     260    260       NAD. {ECO:0000250}.
SQ   SEQUENCE   317 AA;  34750 MW;  77F6577E0596F6DF CRC64;
     MTKVYIAGAI PEVGLNLLKE HFEVDMYDGE GLIDKETLKK GVEHADALVS LLSTSVDKDI
     IDSANNLKII ANYGAGFNNI DVEYARQQNI DVTNTPHAST NATADLTIGL ILSVARRIVE
     GDHLSRTTGF DGWAPLFFRG REVSGKTIGI IGLGEIGGAV AKRARAFDMD VLYTGPHRKE
     EKERDIGAKY VDLDTLLKNA DFITINAAYN PSLHHMIDTE QFNKMKSTAY LINAGRGPIV
     NEQSLVEALD NKVIEGAALD VYEFEPEITD ALKSFKNVVL TPHIGNATFE ARDMMAKIVA
     NDTIKKLNGD EPQFIVN
//
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