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Database: UniProt
Entry: Q8CRT9
LinkDB: Q8CRT9
Original site: Q8CRT9 
ID   PCRA_STAES              Reviewed;         729 AA.
AC   Q8CRT9;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   28-FEB-2018, entry version 94.
DE   RecName: Full=ATP-dependent DNA helicase PcrA;
DE            EC=3.6.4.12;
GN   Name=pcrA; OrderedLocusNames=SE_1590;
OS   Staphylococcus epidermidis (strain ATCC 12228).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J.,
RA   Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z.,
RA   Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Essential helicase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
DR   EMBL; AE015929; AAO05189.1; -; Genomic_DNA.
DR   RefSeq; NP_765145.1; NC_004461.1.
DR   RefSeq; WP_002457083.1; NC_004461.1.
DR   ProteinModelPortal; Q8CRT9; -.
DR   SMR; Q8CRT9; -.
DR   STRING; 176280.SE1590; -.
DR   EnsemblBacteria; AAO05189; AAO05189; SE_1590.
DR   GeneID; 1056988; -.
DR   KEGG; sep:SE1590; -.
DR   PATRIC; fig|176280.10.peg.1554; -.
DR   eggNOG; ENOG4105C4R; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   KO; K03657; -.
DR   OMA; YQDTNRT; -.
DR   BioCyc; SEPI176280:G1G05-1635-MONOMER; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.10.160; -; 1.
DR   InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01073; pcrA; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding.
FT   CHAIN         1    729       ATP-dependent DNA helicase PcrA.
FT                                /FTId=PRO_0000102063.
FT   DOMAIN        6    285       UvrD-like helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00560}.
FT   DOMAIN      286    560       UvrD-like helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00617}.
FT   NP_BIND      30     35       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00560}.
FT   BINDING     283    283       ATP. {ECO:0000250}.
SQ   SEQUENCE   729 AA;  83812 MW;  1477889E446E1D92 CRC64;
     MNALVKNMNS EQSEAVRTTE GPLLIMAGAG SGKTRVLTHR IAYLLDEKDV SPYNILAITF
     TNKAAKEMKA RVEHLVGEEA QVIWMSTFHS MCVRILRRDA DRIGIERNFT IIDPTDQKSV
     IKDVLKSENI DSKRFEPRMF IGAISNLKNE LKTPEDAQKE ANDFHSQMVA TVYKGYQRQL
     SRNEALDFDD LIMTTINLFE RVPETLEYYQ NKFQYIHVDE YQDTNKAQYT LVKLLANKFK
     NLCVVGDSDQ SIYGWRGADI QNILSFEEDY PEAKTIFLEQ NYRSTKNILN AANEVIKHNS
     ERKPKGLWTA NSGGDKIQYY EAMTERDEAE YVVKEIMKHQ RSGKKYSEMA ILYRTNAQSR
     VLEETFMKSN IPYTMVGGQK FYDRKEIKDL LSYLRVIANS NDDISLQRII NVPKRGIGPS
     SVEKIQTYAL QNNISMFDAL AEVDFIGLSK KVTQECISFY EMIQNLIKEQ EFLEISEIVD
     EVLQKSGYRD MLDREQSIES RSRLENLDEF MSVPKDYEEN TPLEEQSLIN FLTDLSLVAD
     IDEADTQNGV TLMTMHSAKG LEFPIVFIMG MEESLFPHIR AIKSEDDHEM EEERRICYVA
     ITRAEELLYI TNATTRMLFG RSQSNMPSRF LKEIPEDLLD SHTGQKRQTI SPKSQPKRGF
     SKRTTSTKKQ VSSSDWKVGD KVMHKAWGEG MVSNVNEKNG SVELDIIFKS EGPKRLLAQF
     APITKKEDS
//
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