ID Q8CVE7_LEPIN Unreviewed; 423 AA.
AC Q8CVE7;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Cell wall-associated hydrolase/lipoprotein {ECO:0000313|EMBL:AAN49612.1};
GN OrderedLocusNames=LA_2413 {ECO:0000313|EMBL:AAN49612.1};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS 56601).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN49612.1, ECO:0000313|Proteomes:UP000001408};
RN [1] {ECO:0000313|EMBL:AAN49612.1, ECO:0000313|Proteomes:UP000001408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 {ECO:0000313|EMBL:AAN49612.1,
RC ECO:0000313|Proteomes:UP000001408};
RX PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT "Unique physiological and pathogenic features of Leptospira interrogans
RT revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the peptidase C40 family.
CC {ECO:0000256|ARBA:ARBA00007074}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE010300; AAN49612.1; -; Genomic_DNA.
DR RefSeq; NP_712594.1; NC_004342.2.
DR RefSeq; WP_000488428.1; NC_004342.2.
DR AlphaFoldDB; Q8CVE7; -.
DR STRING; 189518.LA_2413; -.
DR PaxDb; 189518-LA_2413; -.
DR EnsemblBacteria; AAN49612; AAN49612; LA_2413.
DR KEGG; lil:LA_2413; -.
DR PATRIC; fig|189518.3.peg.2393; -.
DR HOGENOM; CLU_648592_0_0_12; -.
DR InParanoid; Q8CVE7; -.
DR OrthoDB; 9813368at2; -.
DR Proteomes; UP000001408; Chromosome I.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR47360:SF1; ENDOPEPTIDASE NLPC-RELATED; 1.
DR PANTHER; PTHR47360; MUREIN DD-ENDOPEPTIDASE MEPS/MUREIN LD-CARBOXYPEPTIDASE; 1.
DR Pfam; PF00877; NLPC_P60; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS51935; NLPC_P60; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AAN49612.1};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023139};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001408}.
FT DOMAIN 291..419
FT /note="NlpC/P60"
FT /evidence="ECO:0000259|PROSITE:PS51935"
SQ SEQUENCE 423 AA; 47187 MW; 7E9A8B78DAA7FD26 CRC64;
MFRIIQIFFV LVWMPISIFA DPFSDLLKED FEAGQTLLIR NSVFQKLGGK SKDPKVIEIT
KNTIPWAIME GLAPDTIADL IVNQYYVSLS GLRFTEAEDA IPILSKQKLS EKDFVLVSLF
VKETSQAGIR EEIRNVFLST ALKSRWDGFA ILAGGRALIA GKFVGIPENR LASRILGSFP
NRGAIVPFEK TDSAFRQAIF FNPTNDRYTL ASDLLSQLKS LHEGTKSRSL DSWTETISQA
RTLDRSLDSA GEIVIGDRPK FGFEENIPEP PLVPEVEPEA PVQPGKVEWE ILNSSNLVSV
VKEWLGTPYY WGGTSKKGVD CSGFTFSSLT DKRVGVPVKI LPRLGREQAN SGSKVSHQNL
RAGDLIFFSA SPNQSKITHV GLVINEKEFA HASSTRGVVV DKISMKWWID RYVTSRRLFK
KVL
//
