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Database: UniProt
Entry: Q8CWT8_STRR6
LinkDB: Q8CWT8_STRR6
Original site: Q8CWT8_STRR6 
ID   Q8CWT8_STRR6            Unreviewed;       412 AA.
AC   Q8CWT8;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 104.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   Name=cps2K {ECO:0000313|EMBL:AAK99122.1};
GN   OrderedLocusNames=spr0318 {ECO:0000313|EMBL:AAK99122.1};
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101 {ECO:0000313|EMBL:AAK99122.1, ECO:0000313|Proteomes:UP000000586};
RN   [1] {ECO:0000313|EMBL:AAK99122.1, ECO:0000313|Proteomes:UP000000586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6 {ECO:0000313|Proteomes:UP000000586};
RX   PubMed=11544234; DOI=10.1128/JB.183.19.5709-5717.2001;
RA   Hoskins J.A., Alborn W.Jr., Arnold J., Blaszczak L., Burgett S.,
RA   DeHoff B.S., Estrem S., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A., LaGace R., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.,
RA   McHenney M., McLeaster K., Mundy C., Nicas T.I., Norris F.H.,
RA   O'Gara M., Peery R., Robertson G.T., Rockey P., Sun P.-M.,
RA   Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C., Baltz R.H.,
RA   Jaskunas S.Richard., Rosteck P.R.Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; AE007317; AAK99122.1; -; Genomic_DNA.
DR   PIR; F97911; F97911.
DR   RefSeq; NP_357912.1; NC_003098.1.
DR   RefSeq; WP_000685095.1; NC_003098.1.
DR   STRING; 171101.spr0318; -.
DR   EnsemblBacteria; AAK99122; AAK99122; spr0318.
DR   GeneID; 934772; -.
DR   KEGG; spr:spr0318; -.
DR   PATRIC; fig|171101.6.peg.357; -.
DR   eggNOG; ENOG4107RHE; Bacteria.
DR   eggNOG; COG1004; LUCA.
DR   HOGENOM; HOG000280378; -.
DR   KO; K00012; -.
DR   OMA; YRAMGRP; -.
DR   BioCyc; SPNE171101:SPR0318-MONOMER; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 2.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000586};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124,
KW   ECO:0000313|EMBL:AAK99122.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000586}.
FT   DOMAIN      323    411       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   REGION      142    145       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR500134-2}.
FT   REGION      248    252       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR500134-2}.
FT   ACT_SITE    259    259       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      29     29       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      34     34       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      83     83       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     118    118       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     145    145       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     203    203       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR500134-2}.
FT   BINDING     256    256       Substrate; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-2}.
FT   BINDING     262    262       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     329    329       Substrate; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-2}.
FT   BINDING     330    330       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR500134-2}.
FT   BINDING     337    337       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     412    412       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR500134-2}.
SQ   SEQUENCE   412 AA;  46614 MW;  9494EF2ACDDB0B3A CRC64;
     MKIAVAGTGY VGLSIAVLLS QQHQVMAVDI IPEKVELINQ RKSPIQDDYI EKYLAKKDLN
     LVATLDAKEA YQDADFVVIA APTNYDPKKN FFDTSAVESV IETALKYNPD AIMVIKSTVP
     VGYTESARKK FQTENILFSP EFLRESKALY DNLYPSRIIL GTDKNNERLV SAAETFARLL
     QEGALKENID TLYMGFTEAE AVKLFANTYL ALRVSYFNEL DTYSEMKGLD TQAIIDGVGL
     DPRIGSHYNN PSFGYGGYCL PKDTKQLLAN YEDIPEELIG AIVRSNSTRK DFIADQVLKM
     VDYYDYSAHN IFDERVEKDI IIGIYRLTMK SNSDNFRQSS IQGIMKRIKA KGVRVVIYEP
     TLESGSTFFG SSVINDLEEF KRLSNAIVAN RYDNSLEDVK EKVYTRDIFE RD
//
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