ID Q8DWP9_STRA5 Unreviewed; 475 AA.
AC Q8DWP9;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Arginine/ornithine antiporter {ECO:0000313|EMBL:AAN01024.1};
GN Name=arcD {ECO:0000313|EMBL:AAN01024.1};
GN OrderedLocusNames=SAG2166 {ECO:0000313|EMBL:AAN01024.1};
OS Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=208435 {ECO:0000313|EMBL:AAN01024.1, ECO:0000313|Proteomes:UP000000821};
RN [1] {ECO:0000313|EMBL:AAN01024.1, ECO:0000313|Proteomes:UP000000821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-611 / 2603 V/R {ECO:0000313|Proteomes:UP000000821};
RX PubMed=12200547; DOI=10.1073/pnas.182380799;
RA Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.,
RA Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA DeBoy R.T., Durkin S., Kolonay J.F., Umayam L.A., Madupu R., Lewis M.R.,
RA Radune D., Fedorova N.B., Scanlan D., Khouri H., Mulligan S., Carty H.A.,
RA Cline R.T., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C.,
RA Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R.,
RA Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT "Complete genome sequence and comparative genomic analysis of an emerging
RT human pathogen, serotype V Streptococcus agalactiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC family. {ECO:0000256|ARBA:ARBA00008220}.
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DR EMBL; AE009948; AAN01024.1; -; Genomic_DNA.
DR RefSeq; NP_689151.1; NC_004116.1.
DR RefSeq; WP_000410015.1; NC_004116.1.
DR AlphaFoldDB; Q8DWP9; -.
DR STRING; 208435.SAG2166; -.
DR KEGG; sag:SAG2166; -.
DR PATRIC; fig|208435.3.peg.2169; -.
DR HOGENOM; CLU_007946_1_2_9; -.
DR OrthoDB; 9762947at2; -.
DR Proteomes; UP000000821; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0043858; F:arginine:ornithine antiporter activity; IEA:InterPro.
DR GO; GO:0006527; P:arginine catabolic process; IEA:InterPro.
DR GO; GO:1903826; P:L-arginine transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004754; Amino_acid_antiprt.
DR InterPro; IPR022461; Arg/Orn_antiprt_ArcD.
DR NCBIfam; TIGR00905; 2A0302; 1.
DR NCBIfam; TIGR03810; arg_ornith_anti; 1.
DR PANTHER; PTHR42770; AMINO ACID TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR42770:SF4; ARGININE_ORNITHINE ANTIPORTER-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000821};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 475 AA; 51987 MW; BE336E47048BAF8D CRC64;
MEKEKKLGLL PLTMLVIGSL IGGGIFDLMQ NMSSRAGLVP MLIAWVITAI GMGTFVLSFQ
NLSEKRPDLT AGIFSYAKEG FGNFMGFNSA WGYWLSAWLG NVAYAALLFS SLGYFFKFFG
NGNNIISIIG ASIVIWVVHF LILRGVNTAA FINTIVTFAK LVPVIIFLIS ALLAFKFNIF
SLDIWGNGLH QSIFNQVNST MKTAVWVFIG IEGAVVFSGR AKKHSDIGKA SILALFTMIS
LYVLISVLSL GIMSRPELAN LKTPAMAYVL EKAVGHWGAI LVNLGVIISV FGAILAWTLF
AAELPYQAAK EGAFPKFFAK ENKNKAPINS LLVTNLCVQA FLITFLFTQS AYRFGFALAS
SAILIPYAFT ALYQLQFTLR EDKSTPGHQK NLIIGILATI YAVYLIYAGG FDYLLLTMIA
YTLGMILYIK MRKDDKLPIF VGYEKISAIV ILALCLLCII EIMTGQIDIA AILAG
//
