ID Q8ECW6_SHEON Unreviewed; 557 AA.
AC Q8ECW6;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN Name=dcm {ECO:0000313|EMBL:AAN56018.1};
GN OrderedLocusNames=SO_3006 {ECO:0000313|EMBL:AAN56018.1};
OS Shewanella oneidensis (strain MR-1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=211586 {ECO:0000313|EMBL:AAN56018.1, ECO:0000313|Proteomes:UP000008186};
RN [1] {ECO:0000313|EMBL:AAN56018.1, ECO:0000313|Proteomes:UP000008186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MR-1 {ECO:0000313|EMBL:AAN56018.1,
RC ECO:0000313|Proteomes:UP000008186};
RX PubMed=12368813; DOI=10.1038/nbt749;
RA Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA Read T.D., Eisen J.A., Seshadri R., Ward N., Methe B., Clayton R.A.,
RA Meyer T., Tsapin A., Scott J., Beanan M., Brinkac L., Daugherty S.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J., Weidman J.,
RA Impraim M., Lee K., Berry K., Lee C., Mueller J., Khouri H., Gill J.,
RA Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C.,
RA Nealson K.H., Fraser C.M.;
RT "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT Shewanella oneidensis.";
RL Nat. Biotechnol. 20:1118-1123(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00000743};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014299; AAN56018.1; -; Genomic_DNA.
DR RefSeq; NP_718574.1; NC_004347.2.
DR RefSeq; WP_011072910.1; NZ_CP053946.1.
DR AlphaFoldDB; Q8ECW6; -.
DR STRING; 211586.SO_3006; -.
DR REBASE; 6672; M.SonORF3006P.
DR PaxDb; 211586-SO_3006; -.
DR KEGG; son:SO_3006; -.
DR PATRIC; fig|211586.12.peg.2901; -.
DR eggNOG; COG0270; Bacteria.
DR HOGENOM; CLU_014695_0_0_6; -.
DR OrthoDB; 9813719at2; -.
DR PhylomeDB; Q8ECW6; -.
DR BioCyc; SONE211586:G1GMP-2780-MONOMER; -.
DR Proteomes; UP000008186; Chromosome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0010424; P:DNA methylation on cytosine within a CG sequence; IBA:GO_Central.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF50; DNA (CYTOSINE-5)-METHYLTRANSFERASE CMT3; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AAN56018.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008186};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAN56018.1}.
SQ SEQUENCE 557 AA; 61369 MW; 8D821708E227ABA5 CRC64;
MRGLIVDNFA GGGGASTGMA WALGRSVDIA INHDQDAIAM HSANHPETLH YCESVFDVDP
VQATAGKPVA LAWFSPDCKH FSKAKGTKPV NKEIRGLAWV TIRWAMKVRP RVIMLENVEE
FKTWGPLIQC PVTDAMHPCP ERKGETFNAF VSMLSTGVDA DHPALTECVE TLGLLDSAKL
IKGLGYKVEF RELRACDYGA PTIRKRLFMI ARCDGQPIVW PQPTHGAPDS EAVKSGKLLP
WRTAAECIDW SLPCKSIFGR KKPLAENTLR RIAKGIQRFV IDAKEPFIVP NDVQLAPFIT
EHANASSQRN MPVNEPLRTI CAQVKGGHFA VVQPVLEKVN DNIPTFTEWF AKTKNFGGSY
EEYVSLYGDD QLTDPVLTAA NICKHYGGNY TGPGDDLNNP LPTVTTVDHN ALITSHMIKL
RGTNIGFPMD EPAHTITAGG LHLGEVRAFF IKYYGNEQDG VACNEPLHTI TTNDRFGLVM
IKGEPYQIID IGMRMLEPHE LFACQGFNPE YIINNYNGKS SKKQQVARVG NSVPPQFAEA
LTRANLPELC TQTAEAA
//
