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Database: UniProt
Entry: Q8EI78_SHEON
LinkDB: Q8EI78_SHEON
Original site: Q8EI78_SHEON 
ID   Q8EI78_SHEON            Unreviewed;       329 AA.
AC   Q8EI78;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-NOV-2023, entry version 120.
DE   SubName: Full=Fermentative lactate dehydrogenase NADH dependent LdhA {ECO:0000313|EMBL:AAN54042.1};
DE            EC=1.1.1.28 {ECO:0000313|EMBL:AAN54042.1};
GN   Name=ldhA {ECO:0000313|EMBL:AAN54042.1};
GN   OrderedLocusNames=SO_0968 {ECO:0000313|EMBL:AAN54042.1};
OS   Shewanella oneidensis (strain MR-1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=211586 {ECO:0000313|EMBL:AAN54042.1, ECO:0000313|Proteomes:UP000008186};
RN   [1] {ECO:0000313|EMBL:AAN54042.1, ECO:0000313|Proteomes:UP000008186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-1 {ECO:0000313|EMBL:AAN54042.1,
RC   ECO:0000313|Proteomes:UP000008186};
RX   PubMed=12368813; DOI=10.1038/nbt749;
RA   Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA   Read T.D., Eisen J.A., Seshadri R., Ward N., Methe B., Clayton R.A.,
RA   Meyer T., Tsapin A., Scott J., Beanan M., Brinkac L., Daugherty S.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA   Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J., Weidman J.,
RA   Impraim M., Lee K., Berry K., Lee C., Mueller J., Khouri H., Gill J.,
RA   Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C.,
RA   Nealson K.H., Fraser C.M.;
RT   "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT   Shewanella oneidensis.";
RL   Nat. Biotechnol. 20:1118-1123(2002).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC       ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; AE014299; AAN54042.1; -; Genomic_DNA.
DR   RefSeq; NP_716597.1; NC_004347.2.
DR   RefSeq; WP_011071244.1; NZ_CP053946.1.
DR   AlphaFoldDB; Q8EI78; -.
DR   SMR; Q8EI78; -.
DR   STRING; 211586.SO_0968; -.
DR   PaxDb; 211586-SO_0968; -.
DR   KEGG; son:SO_0968; -.
DR   PATRIC; fig|211586.12.peg.929; -.
DR   eggNOG; COG1052; Bacteria.
DR   HOGENOM; CLU_019796_1_1_6; -.
DR   OMA; VIVTAHQ; -.
DR   OrthoDB; 9805416at2; -.
DR   PhylomeDB; Q8EI78; -.
DR   BioCyc; SONE211586:G1GMP-902-MONOMER; -.
DR   BRENDA; 1.1.1.28; 5706.
DR   Proteomes; UP000008186; Chromosome.
DR   GO; GO:0008720; F:D-lactate dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   CDD; cd12183; LDH_like_2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43026; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR   PANTHER; PTHR43026:SF1; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719,
KW   ECO:0000313|EMBL:AAN54042.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008186}.
FT   DOMAIN          9..327
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          110..297
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   329 AA;  36206 MW;  A51E64A5FAD5BD7D CRC64;
     MRIGFFSAKH YDMQHFNRTN AAFDAQIEYF DYRLCMQTVK LAEGFEVVCA FVNDSLCEEV
     LVELAKGGTK IIAMRCAGFN NVDLVAAKRL GMQVVNVPAY SPESVAEHTV ALMLTLNRKI
     HKAYQRTRDA NFSLEGLVGF NMFGKTVGVI GTGKIGVATI KVLLGFGCKV IAFDPYPNPA
     VEALDVEYQD LDTIYATSDI ISLHCPLTPD NHHLLNKDSF AKMKPGVMVI NTSRGGLLNA
     FDAMEALKLG QIGALGLDVY ENEKELFFED KSNQIIQDDV FRRLSACHNV IFTGHQAFLT
     EEALGAIANT TLSNVQAVLA GKRCGNELF
//
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