ID Q8EKM1_SHEON Unreviewed; 539 AA.
AC Q8EKM1;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=prolyl aminopeptidase {ECO:0000256|ARBA:ARBA00012568};
DE EC=3.4.11.5 {ECO:0000256|ARBA:ARBA00012568};
GN OrderedLocusNames=SO_0071 {ECO:0000313|EMBL:AAN53158.1};
OS Shewanella oneidensis (strain MR-1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=211586 {ECO:0000313|EMBL:AAN53158.1, ECO:0000313|Proteomes:UP000008186};
RN [1] {ECO:0000313|EMBL:AAN53158.1, ECO:0000313|Proteomes:UP000008186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MR-1 {ECO:0000313|EMBL:AAN53158.1,
RC ECO:0000313|Proteomes:UP000008186};
RX PubMed=12368813; DOI=10.1038/nbt749;
RA Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA Read T.D., Eisen J.A., Seshadri R., Ward N., Methe B., Clayton R.A.,
RA Meyer T., Tsapin A., Scott J., Beanan M., Brinkac L., Daugherty S.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J., Weidman J.,
RA Impraim M., Lee K., Berry K., Lee C., Mueller J., Khouri H., Gill J.,
RA Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C.,
RA Nealson K.H., Fraser C.M.;
RT "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT Shewanella oneidensis.";
RL Nat. Biotechnol. 20:1118-1123(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of N-terminal proline from a peptide.; EC=3.4.11.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001585};
CC -!- SIMILARITY: Belongs to the peptidase S33 family.
CC {ECO:0000256|ARBA:ARBA00010088}.
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DR EMBL; AE014299; AAN53158.1; -; Genomic_DNA.
DR RefSeq; NP_715713.1; NC_004347.2.
DR AlphaFoldDB; Q8EKM1; -.
DR STRING; 211586.SO_0071; -.
DR ESTHER; sheon-SO0071; Proline_iminopeptidase.
DR PaxDb; 211586-SO_0071; -.
DR KEGG; son:SO_0071; -.
DR PATRIC; fig|211586.12.peg.71; -.
DR eggNOG; COG0596; Bacteria.
DR HOGENOM; CLU_025429_1_0_6; -.
DR OMA; LNCAYWP; -.
DR OrthoDB; 4510475at2; -.
DR PhylomeDB; Q8EKM1; -.
DR BioCyc; SONE211586:G1GMP-72-MONOMER; -.
DR Proteomes; UP000008186; Chromosome.
DR GO; GO:0008233; F:peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR013595; Pept_S33_TAP-like_C.
DR InterPro; IPR002410; Peptidase_S33.
DR PANTHER; PTHR43798:SF27; HYDROLASE ALPHA/BETA HYDROLASE FOLD FAMILY; 1.
DR PANTHER; PTHR43798; MONOACYLGLYCEROL LIPASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF08386; Abhydrolase_4; 1.
DR PRINTS; PR00793; PROAMNOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000313|EMBL:AAN53158.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008186}.
FT DOMAIN 113..252
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT DOMAIN 398..497
FT /note="Peptidase S33 tripeptidyl aminopeptidase-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08386"
FT REGION 517..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 58590 MW; B2FC3AF4EEDFD213 CRC64;
MRDSMTHRKS HNASACVAIK RSNTGWHKRI STSKIIGLST LMLAMCSATV WASDKPTPPT
TPTNTCYVEG VSDRLQCGFV TVPENPNQPD GKQIQVHYVV LPAVKNANHE EALLAIAGGP
GQSAIDNAAS FNTVLNKVRQ QRDILLIDQR GTGRSNLLNC DAGPQSLLAF NDDNVDSLAE
AQKCRDQLAG SDVTQYGSLN AVKDFEAVRA HLGYKKLHLY GISYGTRMAQ LYMRLYPEHL
ATVTLDGIVP MQQSVLEIGS AIERGFDLLF KDCQETAACH AKFPELKAEF DQVVARLTEG
PIMEQVHDPV TGEKTLLTMT RAKFYGAIRM ALYQTNVRAL VPHAIHQAAK GNYQPLLGLY
ALTTDGAGMA MGMHASVVCG EDIHRITPAM REQAKTSYVG KTMLESLEAS CSVWKVPPVD
ASFSEPIKSD IPTLLLSGEI DPATPPSWGE LAMEKLTNAK HFIAPYATHG VAYQSCANNL
VAELVRTGSV KDLDGECLKK DVRRSFYLNA SSVEPLTTEA ATNSAKDKPK DKPSTGAKE
//