ID Q8EPE0_OCEIH Unreviewed; 373 AA.
AC Q8EPE0;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN Name=citZ {ECO:0000313|EMBL:BAC14124.1};
OS Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS 3954 / HTE831).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=221109 {ECO:0000313|EMBL:BAC14124.1, ECO:0000313|Proteomes:UP000000822};
RN [1] {ECO:0000313|EMBL:BAC14124.1, ECO:0000313|Proteomes:UP000000822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831
RC {ECO:0000313|Proteomes:UP000000822};
RX PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT and its unexpected adaptive capabilities to extreme environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
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DR EMBL; BA000028; BAC14124.1; -; Genomic_DNA.
DR RefSeq; WP_011066562.1; NC_004193.1.
DR AlphaFoldDB; Q8EPE0; -.
DR STRING; 221109.gene:10734416; -.
DR KEGG; oih:OB2168; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_2_1_9; -.
DR OrthoDB; 9800864at2; -.
DR PhylomeDB; Q8EPE0; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000000822; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06110; BSuCS-II_like; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01800; cit_synth_II; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:BAC14124.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000822};
KW Transferase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000313|EMBL:BAC14124.1}.
FT ACT_SITE 258
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 309
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 373 AA; 41993 MW; E69CF718403FEFF4 CRC64;
MTASTKGLEG IVATQSSISS IIDDQLSYVG YRIDDLAENS SFEEIIYLLW NQKLPNKSEL
DELKSQLAEN MDIPDAIINH LRSYDLNTVH PMAALRTAIS LLGLYDNEAD VMDEQANKRK
AVRIQAQIAT IVTTFSRIRK GQEPVKPKKD LSYAENFIYM LNGKEPEDIE VEAINKALVL
HADHELNAST FTARVCVATL SDIYSGITAA IGALKGPLHG GANENVMKML TEIGEEENAI
PYIKEKLANK DKIMGMGHRV YRTGDPRAKF LREMSKELTK LTGQEKWYNM SVKIEDYIKE
NKGLPANVDF YSASVYHSLG LDHDIFTPLF AVSRTSGWIA HILEQYENNR LIRPRAEYTG
PELRDYVSIE QRG
//
