ID NSRR_OCEIH Reviewed; 147 AA.
AC Q8ETG9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=HTH-type transcriptional regulator NsrR;
GN Name=nsrR; OrderedLocusNames=OB0292;
OS Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS 3954 / HTE831).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=221109;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT and its unexpected adaptive capabilities to extreme environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
CC -!- FUNCTION: Nitric oxide-responsive transcriptional regulator.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000305};
CC Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000028; BAC12248.1; -; Genomic_DNA.
DR RefSeq; WP_011064694.1; NC_004193.1.
DR AlphaFoldDB; Q8ETG9; -.
DR SMR; Q8ETG9; -.
DR STRING; 221109.gene:10732495; -.
DR KEGG; oih:OB0292; -.
DR eggNOG; COG1959; Bacteria.
DR HOGENOM; CLU_107144_2_1_9; -.
DR OrthoDB; 9795923at2; -.
DR PhylomeDB; Q8ETG9; -.
DR Proteomes; UP000000822; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00738; rrf2_super; 1.
DR PANTHER; PTHR33221:SF4; HTH-TYPE TRANSCRIPTIONAL REPRESSOR NSRR; 1.
DR PANTHER; PTHR33221; WINGED HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, RRF2 FAMILY; 1.
DR Pfam; PF02082; Rrf2; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51197; HTH_RRF2_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..147
FT /note="HTH-type transcriptional regulator NsrR"
FT /id="PRO_0000271135"
FT DOMAIN 2..133
FT /note="HTH rrf2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT DNA_BIND 28..51
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 92
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 100
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 106
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
SQ SEQUENCE 147 AA; 16726 MW; 3A2BC10F8C6899F7 CRC64;
MNLKKYTDYA LRVLIFTGLK SDQELANIKE IAEVYQISQE HLRKVVHELT KMELVVTIRG
RNGGIKLAKP ASEINIGLLI RQLENDFVLL ECFDKGTNHC VISPGCTLKH VINKALVAFF
KVLEEYTLED LIKNEEELLA LMGIEKV
//
