ID Q8F613_LEPIN Unreviewed; 1196 AA.
AC Q8F613;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 2.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Cytoplasmic membrane protein {ECO:0000313|EMBL:AAN48698.2};
GN OrderedLocusNames=LA_1499 {ECO:0000313|EMBL:AAN48698.2};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS 56601).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN48698.2, ECO:0000313|Proteomes:UP000001408};
RN [1] {ECO:0000313|EMBL:AAN48698.2, ECO:0000313|Proteomes:UP000001408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 {ECO:0000313|EMBL:AAN48698.2,
RC ECO:0000313|Proteomes:UP000001408};
RX PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT "Unique physiological and pathogenic features of Leptospira interrogans
RT revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
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DR EMBL; AE010300; AAN48698.2; -; Genomic_DNA.
DR RefSeq; NP_711680.2; NC_004342.2.
DR AlphaFoldDB; Q8F613; -.
DR STRING; 189518.LA_1499; -.
DR PaxDb; 189518-LA_1499; -.
DR EnsemblBacteria; AAN48698; AAN48698; LA_1499.
DR KEGG; lil:LA_1499; -.
DR PATRIC; fig|189518.3.peg.1499; -.
DR HOGENOM; CLU_264982_0_0_12; -.
DR InParanoid; Q8F613; -.
DR OrthoDB; 2082707at2; -.
DR Proteomes; UP000001408; Chromosome I.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.1220; -; 5.
DR Gene3D; 2.60.40.3710; -; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 3.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032812; SbsA_Ig.
DR PANTHER; PTHR23221; GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR23221:SF7; PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D; 1.
DR Pfam; PF13205; Big_5; 6.
DR Pfam; PF01839; FG-GAP; 4.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 7.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
DR PROSITE; PS51470; FG_GAP; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 18..116
FT /note="SbsA Ig-like"
FT /evidence="ECO:0000259|Pfam:PF13205"
FT DOMAIN 123..225
FT /note="SbsA Ig-like"
FT /evidence="ECO:0000259|Pfam:PF13205"
FT DOMAIN 232..333
FT /note="SbsA Ig-like"
FT /evidence="ECO:0000259|Pfam:PF13205"
FT DOMAIN 338..443
FT /note="SbsA Ig-like"
FT /evidence="ECO:0000259|Pfam:PF13205"
FT DOMAIN 449..555
FT /note="SbsA Ig-like"
FT /evidence="ECO:0000259|Pfam:PF13205"
FT DOMAIN 562..657
FT /note="SbsA Ig-like"
FT /evidence="ECO:0000259|Pfam:PF13205"
SQ SEQUENCE 1196 AA; 122141 MW; 8E3757CC8A4E2BC6 CRC64;
MPFFAYLDFS NRSADSSFNV SQISPGPNVT GVSLNTSIQV GFSQKLDSSS IQSQSIQLTQ
GNTIIPGNFT STEKTLLFNP TSSLAASTVY SVSISKDIKS MDGSSLSEDY TWSFTTNTIV
DLVAPDVSLR TPTIGANLVP NNTSVQIAFT ETMNCTSINI VNFTLKNNVT NVLEPSNVVC
LGSVATLTPN NPLAFNTVYR VDILSTAKDL ANNPLVNAYN WTFTTGVAPD LTVPTVSFVN
PTPNAQNVPI NETISIAFSE PINCATIIGS IVLDDNILIP GSVNGNPGCT GTTASFTPLG
NLTPNTNYTV TVSNAITDLQ NNPLTPSTWS FTTAAAVDQT QPTVTFTVPS ANANGVGTNV
NPMVVFSEPM SCASVTSASF RLKRQATGVY LIGSVNCFGT SATWTPDPVN PLAFNTTYTV
EIDQGALDTF NNPLIPINWN FTTGPGPDLT PPSVAVVTPA NAAIGVPTNG GVSIAFSEAM
NCGSILGGIT LDDDPTTPGT VIPININCNG NTVSFAPTIP PLAFNTTYTV TILNTVTDSN
NNALNGGNYA WSFTTGVAPD LVPPQVSLVS PLSGAVGVAT NANITVAFNE TINCSTLNFT
VNNGINGTVN CSGSSATFIP SALTPLNAGT NYTATILTVN DIVGNPIGAA FGWSFTTGAA
PDVTPPVVTI QNLRNNSIVE TGFVIGTATD AGTITSVEVS LDNGAFVPAT GTNPWKFKLP
SDINTWKQNS QHTIIARAKD LANNLTTTAA ISVRKGNNKD INGDGYVDLV SAEYGQGLLY
IFHSSGNAGM TITNAQSASK IIVGVAAEEF GRTVSMGDLN GDGFADVISG APGWNGAQGR
VYIFHSSGNA GVNISFSGFA TKTISGANAG ARFGDSIVTG DLNGDGYADL ASGEPVFNGS
QGRVYVFHSA GAAGVTQINS AAANSTLTGE NATDRFGYSL STGNMNGDNF ADLAIGAPGY
GAGVGGGFVV NQGKVYIHHG AAGGLGGVIT TLTNDSAGNA GEFGISLFTA DFNGDGNSDL
AIGSPNLGGG TGRVSVFTSA GGVGINTSTI GNAPLMINGT AVGNAFGISL TAQDLNLDGR
PDLISATVIP NRVFVFHMPG AGAIGGFLTT GNATTQITSA FAGIGVSPNA PKTPISGGDI
NGDGFPDLFV GGSSDNIFIF HSSTVGTGLL TNTTATAAGA ITSSGLANGF FGCSVY
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