ID Q8G6U0_BIFLO Unreviewed; 527 AA.
AC Q8G6U0;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Probable voltage gated channel protein {ECO:0000313|EMBL:AAN24372.1};
GN OrderedLocusNames=BL0548 {ECO:0000313|EMBL:AAN24372.1};
OS Bifidobacterium longum (strain NCC 2705).
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=206672 {ECO:0000313|EMBL:AAN24372.1, ECO:0000313|Proteomes:UP000000439};
RN [1] {ECO:0000313|EMBL:AAN24372.1, ECO:0000313|Proteomes:UP000000439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCC 2705 {ECO:0000313|Proteomes:UP000000439};
RX PubMed=12381787; DOI=10.1073/pnas.212527599;
RA Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA Zwahlen M.C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT the human gastrointestinal tract.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014295; AAN24372.1; -; Genomic_DNA.
DR RefSeq; NP_695736.1; NC_004307.2.
DR RefSeq; WP_003833659.1; NC_004307.2.
DR AlphaFoldDB; Q8G6U0; -.
DR STRING; 206672.BL0548; -.
DR EnsemblBacteria; AAN24372; AAN24372; BL0548.
DR GeneID; 45581963; -.
DR KEGG; blo:BL0548; -.
DR PATRIC; fig|206672.9.peg.1292; -.
DR HOGENOM; CLU_015263_7_4_11; -.
DR OrthoDB; 9767361at2; -.
DR PhylomeDB; Q8G6U0; -.
DR Proteomes; UP000000439; Chromosome.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR CDD; cd01031; EriC; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000439};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 439..520
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 527 AA; 56047 MW; 7DCBF8AFA68EC349 CRC64;
MTGNDAAHDI RRLIPRFDHL KWKMAAAGIV IGLVSGLLVV VYRLGIEYGT DASRWIYARI
RETPWLIAPW AVAAVAAALA IAWMVGKEPM AGGSGIPQTN GVVICGLKMR WQTILPVRFV
GGLLGALFGL SLGREGPSIQ IGASGAQCVS HRLRGRRRED MQEHYLVTAG AAAGLSAAFS
APLSGMMFAL EGVHRSFSPA ILMGATAASL TADFVSKYCF GLRPVLDFGD IGQLSLEEYV
WLIPLGLVAG LVGSLMNRSL LGFQTLYGKL PAWSRPMIAI AIALPVGIWL PDVLGGGSNL
IDTAEHARVG LGMLCLLFVA KMLFTSTSFG SGAPGGIFMP ILAVGSLAGG ICGEVLHRFG
DLPSDAVAVF AVCVMTGTLA ASVKTPITSI LLAVEMSGTL THMLPVAAVA FIALLVSDLL
RTKPIYGELL ERYVRAQGMQ MAIASHVGSG IMELPLEMGA IADGKRVRDV RWPSGCLIIG
LRRGESEIVP RGDTRLRAGD YLVVLFSGEE EREVRPAMRR LCDARLD
//
