ID AB3F_ARATH Reviewed; 715 AA.
AC Q8H0V6; Q9SGW1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=ABC transporter F family member 3;
DE Short=ABC transporter ABCF.3;
DE Short=AtABCF3;
DE AltName: Full=GCN20-type ATP-binding cassette protein GCN3;
GN Name=ABCF3; Synonyms=GCN3; OrderedLocusNames=At1g64550; ORFNames=F1N19.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCF family.
CC EF3 (TC 3.A.1.121) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF19673.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g64540 has been split into 2 genes: At1g64540 and At1g64550.; Evidence={ECO:0000305};
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DR EMBL; AC009519; AAF19673.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34252.1; -; Genomic_DNA.
DR EMBL; BT002015; AAN72026.1; -; mRNA.
DR EMBL; BT010544; AAQ65167.1; -; mRNA.
DR PIR; A96669; A96669.
DR RefSeq; NP_176636.1; NM_105130.4.
DR AlphaFoldDB; Q8H0V6; -.
DR SMR; Q8H0V6; -.
DR BioGRID; 27984; 1.
DR STRING; 3702.Q8H0V6; -.
DR iPTMnet; Q8H0V6; -.
DR PaxDb; 3702-AT1G64550-1; -.
DR ProteomicsDB; 244398; -.
DR EnsemblPlants; AT1G64550.1; AT1G64550.1; AT1G64550.
DR GeneID; 842763; -.
DR Gramene; AT1G64550.1; AT1G64550.1; AT1G64550.
DR KEGG; ath:AT1G64550; -.
DR Araport; AT1G64550; -.
DR TAIR; AT1G64550; ABCF3.
DR eggNOG; KOG0062; Eukaryota.
DR HOGENOM; CLU_000604_36_6_1; -.
DR InParanoid; Q8H0V6; -.
DR OMA; CTHIADI; -.
DR OrthoDB; 5476589at2759; -.
DR PhylomeDB; Q8H0V6; -.
DR PRO; PR:Q8H0V6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8H0V6; baseline and differential.
DR Genevisible; Q8H0V6; AT.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
DR CDD; cd03221; ABCF_EF-3; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR032781; ABC_tran_Xtn.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19211:SF14; ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3; 1.
DR PANTHER; PTHR19211; ATP-BINDING TRANSPORT PROTEIN-RELATED; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF12848; ABC_tran_Xtn; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW Acetylation; ATP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22223895"
FT CHAIN 2..715
FT /note="ABC transporter F family member 3"
FT /id="PRO_0000274941"
FT DOMAIN 175..436
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 504..713
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 96..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 207..214
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 537..544
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0007744|PubMed:22223895"
SQ SEQUENCE 715 AA; 79644 MW; 6CA38DEDFCD1D392 CRC64;
MTEVASSVVY EVLGRRAQDV DEPIMDYIIN VLADEDFDFG EEGEGAFDAV GELLVAAECV
SDFEECRLVC SKLSDKFGKH GLVKPTPTVR SLAMPVRMND GMDDGPVKKK KPEPVDGPLL
TERDLAKIER RKKKDDRQRE LQYQQHVAEM EAAKAGMPTV SVNHDTGGGS AIRDIHMDNF
NVSVGGRDLI VDGSITLSFG RHYGLVGRNG TGKTTFLRYM AMHAIEGIPT NCQILHVEQE
VVGDKTTALQ CVLNTDIERT KLLEEEIQIL AKQRETEEPT AKDGMPTKDT VEGDLMSQRL
EEIYKRLDAI DAYTAEARAA SILAGLSFTP EMQLKATNTF SGGWRMRIAL ARALFIEPDL
LLLDEPTNHL DLHAVLWLET YLTKWPKTFI VVSHAREFLN TVVTDIIHLQ NQKLSTYKGN
YDIFERTREE QVKNQQKAFE SSERSRSHMQ AFIDKFRYNA KRASLVQSRI KALDRLAHVD
QVINDPDYKF EFPTPDDKPG PPIISFSDAS FGYPGGPLLF RNLNFGIDLD SRIAMVGPNG
IGKSTILKLI SGDLQPSSGT VFRSAKVRVA VFSQHHVDGL DLSSNPLLYM MRCYPGVPEQ
KLRSHLGSLG VTGNLALQPM YTLSGGQKSR VAFAKITFKK PHLLLLDEPS NHLDLDAVEA
LIQGLVLFQG GICMVSHDEH LISGSVDELW VVSDGRIAPF HGTFHDYKKL LQSST
//
