ID TAAR1_MACMU Reviewed; 338 AA.
AC Q8HZ64;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=Trace amine-associated receptor 1;
DE Short=TaR-1;
DE Short=Trace amine receptor 1;
GN Name=TAAR1; Synonyms=TA1, TAR1, TRAR1;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Miller G.M., Madras B.K.;
RT "Cloning of trace amine receptor 1 (TAR1) from Rhesus monkey.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for trace amines, including beta-phenylethylamine
CC (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest
CC affinity for b-PEA and p-TYR. Unresponsive to classical biogenic
CC amines, such as epinephrine and histamine and only partially activated
CC by dopamine and serotonin. Trace amines are biogenic amines present in
CC very low levels in mammalian tissues. Although some trace amines have
CC clearly defined roles as neurotransmitters in invertebrates, the extent
CC to which they function as true neurotransmitters in vertebrates has
CC remained speculative. Trace amines are likely to be involved in a
CC variety of physiological functions that have yet to be fully
CC understood. The signal transduced by this receptor is mediated by the
CC G(s)-class of G-proteins which activate adenylate cyclase (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY135366; AAN06172.1; -; Genomic_DNA.
DR RefSeq; NP_001074234.1; NM_001080765.1.
DR AlphaFoldDB; Q8HZ64; -.
DR SMR; Q8HZ64; -.
DR STRING; 9544.ENSMMUP00000019771; -.
DR BindingDB; Q8HZ64; -.
DR ChEMBL; CHEMBL1926495; -.
DR DrugCentral; Q8HZ64; -.
DR GlyCosmos; Q8HZ64; 2 sites, No reported glycans.
DR PaxDb; 9544-ENSMMUP00000019771; -.
DR GeneID; 708944; -.
DR KEGG; mcc:708944; -.
DR CTD; 134864; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q8HZ64; -.
DR OMA; MQLCCES; -.
DR OrthoDB; 2901788at2759; -.
DR PRO; PR:Q8HZ64; -.
DR Proteomes; UP000006718; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR CDD; cd15314; 7tmA_TAAR1; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009133; TAAR1.
DR InterPro; IPR009132; TAAR_fam.
DR PANTHER; PTHR24249; HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24249:SF415; TRACE AMINE-ASSOCIATED RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01831; TRACEAMINE1R.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..338
FT /note="Trace amine-associated receptor 1"
FT /id="PRO_0000070142"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..286
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 338 AA; 38797 MW; 9EE7B35456BB409B CRC64;
MPFCHNIINI SCVKNNWSND VRASLYSLMA LIILTTLVGN LIVIVSISHF KQLHTPTNWL
IHSMATVDFL LGCLVMPYSM VRSAEHCWYF GEVFCKIHTS TDIMLSSASI FHLSFISIDR
YYAVCDPLRY KAKINILVVC VMIFISWSVP AVFAFGMIFL ELNFKGAEEI YYKHVHCRGG
CSVFFSKISG VLAFMTSFYI PGSIMLCIYY RIYLIAKEQA RSINDANQKL QIGLEMKNGI
SQSKERKAVK TLGIVMGVFL ICWCPFFVCT VIDPFLHYTI PPTLNDVLIW FGYLNSTFNP
MVYAFFYPWF RKALKMILFG KIFQKDSSRC KLFLESSS
//
