ID Q8I1X6_PLAF7 Unreviewed; 1964 AA.
AC Q8I1X6;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Liver specific protein 2, putative {ECO:0000313|EMBL:CAD49145.1};
GN ORFNames=PF3D7_0405300 {ECO:0000313|EMBL:CAD49145.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD49145.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|EMBL:CAD49145.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
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DR EMBL; AL844503; CAD49145.1; -; Genomic_DNA.
DR RefSeq; XP_001351365.1; XM_001351329.1.
DR AlphaFoldDB; Q8I1X6; -.
DR SMR; Q8I1X6; -.
DR STRING; 36329.Q8I1X6; -.
DR PaxDb; 5833-PFD0260c; -.
DR EnsemblProtists; CAD49145; CAD49145; PF3D7_0405300.
DR GeneID; 812430; -.
DR KEGG; pfa:PF3D7_0405300; -.
DR VEuPathDB; PlasmoDB:PF3D7_0405300; -.
DR HOGENOM; CLU_234550_0_0_1; -.
DR InParanoid; Q8I1X6; -.
DR OMA; NHDNPDS; -.
DR OrthoDB; 257392at2759; -.
DR Proteomes; UP000001450; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR010884; 6_CYS_dom.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR PANTHER; PTHR16021:SF27; FI18411P1; 1.
DR PANTHER; PTHR16021; MANSC DOMAIN CONTAINING PROTEIN 1; 1.
DR SMART; SM00970; s48_45; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS51701; 6_CYS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1316..1510
FT /note="6-Cys"
FT /evidence="ECO:0000259|PROSITE:PS51701"
FT REGION 361..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1877..1897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 443..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 362..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1964 AA; 233714 MW; D6BC442EDFB9A8D1 CRC64;
MEKGSILSFI FFCSVVIFIR FIGYFFCNRY MTEEPYNNIF EIIKPENLYS SLLLLSNEKE
NDFPSSTNCN GYMKCIPFYN NVSERWKRYN FIQLYIIRSA LNIHVMSKYN MLNKYNKETN
RLLKRNNNVE NRINNISNHY LCSGFKKENR LFFLLFYKTI KMMKLYIRNL FMKYIKIYYK
TKHFEKNIET NKKVVYVERD NLFDIERNNL FDILYMLKRI DSYVKNIYSI ISNNFLYVIR
IIFLPFEKIY FSLKSLIMIK KMNMSSSYYY YYVNMFSLYK KNYNKYEEIF IHEQRVIYPN
EYLKNEMLDK YRRVIRILSG QHDNPFIDSL LINPEKIEKD DLDVKQKKKK IIEELKKKKE
NTNTNTNTST NTSANTNTST NTSANTNTST KESHILDESK LETFYRDELD KMGKEEIETY
FKGNIDKKSL DEFHKILLEE LNKMDKDELY EMYREELNRI EQEKIRNMNK EEINKTYKDE
INNMNSDQVD KIHREELEKI EKEKINKMDK DEIDKIYREE LDKMDRDAIY SMYIEDISNK
NIKDLIKNEK ETNKDKNKKK DIDINKKKKK DIDIDVDIDK DIHKDHVEEL YGEVKNKLSK
EELDRMDRDA LYRVYLEELD RMNRDELYRV YLEELEKIDK EEKEKIHREK LHKIEKEKIN
KMDKDQIDKI YEEELNKMDS DEIQHVRRAI LQDIQKEKIQ NLELEEIDRL YKEELDRMDR
EARYEIPMRN LSRNEKDNII HRNIKNESNQ KNKKENVNVF IIHDNNDSNN NNNNNNRDVN
NLNNKHTNNN YNENVEVELV VRNLDKDKGA KIEDIIDYFN KEIKKDKNVN VSNIVNFLNS
KVGKDNTPIQ HKKENQVDVV RKNIQIIQED NIKNKGQKDN TEMLDNNKEI TNIDIKNVDD
IKNVGDIKSV GDIKSVDDIN NVDGIKNVDG IKNVDGIKNV DGINNVGDIN NAGDTNNAGD
INNVGDINNS VDIYNVEHID EAEKKPNLDN PKKFDWTQVF KDKVTEKIKN EEKFNNSKEN
IQNDIRDKEI HKDDRIKGIT SREKNAEEIN NNEKKDKFVY EFYTSNKKEN IDKEEENNID
DKNIKIEIEP NYEINNNFEE ENKNEINVII DKEAKNNMDK DDSNNNNNIQ KNNIIIKDNT
NVSEEVHITE SSKEIAEFFN NIIKNSNILD MCSKMNASDS EKGFICINGN NYIINPGTYH
IINIKYPDYN NVRKKWYDSM DCISINNKDE NNNNKEHNYY NKNDDDLYLK KSVEEFIPGF
LSNINKVDDL ARIFTPSFIQ NDIFLNCIYK YRNDFDKNNN IYSFPMKIFL RKNSTKIKGC
SFQIDEDPLL YKDYSEKESF LSNKIILNNS NRNTECVLHA SNEIVGFQCG PPYKSYDNIQ
YRHLTNKSND IQKNIFGIYS NNNSSYSHLF KNIFNNEHKL YNVGGYFQTE PINCFEFVND
NINVEDILPG AVPFPRFDLI HHDLDVNQTR YILLNETNQD KTISCTCNYF TEPNIVYTGK
IIIKVEEEKI YKTKKLQTEF NDIINNKKEI YHEKKMNHII KEKKDEDEND MSFNKNYVNN
YNENFKINDI NNFYNRNNHP NNNYHNDYHN NHSSKGNHTN KIHDTFLKNK YNISFNNLKF
YNIKHENKNN QDVINYEYNV DDYHEVQDGQ DESFKEEEDF IDFKENIIND NTNHNNTDLD
DDKYNKYHNN NNNNNNNSSF KSIESNLDLQ RSILQSGDTQ QVVVINKSKN VNVLFPDKKK
NHTHPNEEKR TFPKYISLVY KEKNKDNEKI DKTLTFIKEF YPPLLRGGKD SDPENKQTGV
EINNGVEKKN DVQIKNDVEI KNDVEIKNDV EINDDVEIKN DVEIKNDVEI KNDVEINDDV
EINDDVEINN GVEINDGVEN KDNIHEGNNN LENDSFNEDT IEEPFENIFD FINEETSSNE
NSEIILDSAD SIKRKLGHNF LDIISAGKFK IRHKEKKTKN KKKK
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