ID Q8I410_PLAF7 Unreviewed; 2914 AA.
AC Q8I410;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 131.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=PF3D7_0509400 {ECO:0000313|EMBL:CAD51459.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51459.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|EMBL:CAD51459.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
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DR EMBL; AL844504; CAD51459.1; -; Genomic_DNA.
DR RefSeq; XP_001351652.1; XM_001351616.1.
DR IntAct; Q8I410; 2.
DR STRING; 36329.Q8I410; -.
DR PaxDb; 5833-PFE0465c; -.
DR EnsemblProtists; CAD51459; CAD51459; PF3D7_0509400.
DR GeneID; 812845; -.
DR KEGG; pfa:PF3D7_0509400; -.
DR VEuPathDB; PlasmoDB:PF3D7_0509400; -.
DR HOGENOM; CLU_226416_0_0_1; -.
DR InParanoid; Q8I410; -.
DR OMA; MGRSIDM; -.
DR OrthoDB; 169836at2759; -.
DR PhylomeDB; Q8I410; -.
DR Proteomes; UP000001450; Chromosome 5.
DR GO; GO:0005730; C:nucleolus; IDA:GeneDB.
DR GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006360; P:transcription by RNA polymerase I; IEA:GOC.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 2.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 2.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 633..936
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 207..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2343..2517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2524..2543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2576..2609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2365..2396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2406..2434
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2435..2511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2576..2608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2914 AA; 340677 MW; 7ED0547C0BF376EE CRC64;
MYDINKSICA EIKSAELDVL NSGELRRISM GKYENEKYEY EKTHKSGVVT KMYYDPKYGT
IDHNQICSVC FERHENCTGH IGHIEFVLPL FNPLFYKELQ ELLNLICYHC YNFCCSEDVI
FLLKHIFQLK SLNQIESTNK IKYKKNCDYE YIIDQVEKLY KKICKDSNIS LDDIVEAIYD
DYENVHEDKD GNFDESVDLL DSLEKIKDEP DEKNKNNNNK NNNNNNNNNN NNYNNDVDID
VDNNNNNVDI NVDNNNNYFN SDLVDLAPNE EIYEEETDAG RSDDNNKENK PDYNKLKERI
KKYKFDANKL AFQSNYNYEE YLILSKTIKL HMKKSSKCCF CKFQRNISAK VSQRRDTINF
IGVHTNNPFF KKYMPKKKQK KNEKDDQEDV DDLENMNNID DINYNDDVDN MQHMNDDESQ
LNSIQSRNEN NKLMIKRESK KIEYNNNVND ESIKIEEDNN EDDDKQMDRE SSYPHNNNNN
NNDNNENYNK LSGGYENSFN EISTDNIRND KNKNSTFADM VNHYNRTQAP KEKCTIRLFS
FQVIDILKKI FENNNKDIIN LLYPFTKRDG YKKFFLYDMG VSGNRFRSQS KGIHVRTKIT
NTLCRFNNFI KLCINAKKKV DFDYLLEHNK KDLKLYKDMF SVFSLKMKYK FNNNIMDDDT
DITKMDFLKY YTLVYNNKSA YINILFSTLQ LGVNTFYDST LTEKVNNKHL KNISIRQILD
KKEGILRKNI MGKRVNNCAR TVISPDTFIE TNQIGMPIEF AKVLTIDEYI TQNNFTYIKK
LIENGPNIYP GALSYRDSNG RVFKLSHKYE DRLKVIEKIE KLNFQTENSY ILHRHARDGD
VVIMNRQPTL HKFSIMAHYL KIFEKEKVFR LNYVNCSSYN ADFDGDEMNL HLLQTPLARA
EATHLMNCDF LFTSFKDGSP LRGLAQDFIL GGLHLTSLET FLNYDEYCNL LQCSLNSLIS
QKNSFFIKKK NNNNNNNKKN TNRTNSIMKN TRNSQYNIIQ NDLNNNDSKE DYLKKMSILK
NQQSLDDNAK ISHPVSNDEA RNNSIYEPTN NLLKPQDIDI LKEINHGEQF NGNVLKITNY
NYLDPYAIIL NRTSFTIITE EPAILYPKKL WTGKQLITSI LKTVIDKVAI ETYNKYNDNE
FMNTYKGINY VAKAKTSPDL WSFDPLKENE VIIKNSELLQ GVLDKLHFGA SSNSLVHLCH
ELFGPKTSAV MLDCFGRLFI NFLQLRGTSL SLYDFILNKN AKKEKSLIKK RISFTGFYLQ
NLFAYSIANS VNADITEMNS YTKKKMNTGN QRKKLILNKM YDLYEKQNEL INNNFNEKEN
YLNKMEKRNI KKDSHVMKDE HILSISENSY LLALLNKELQ NVIYHILNEV QFCDDDASLL
NKEKNEKENE KENKIANTCI NYKHNNSHVD DEQNCNSSLY SCVQYVLNKD LFNLYEKYLN
GKNEEANKHI LYNNCQIDER NNHFLNSVTN KLYKALKEPT FFNSTSFTIK KITKVIEKVL
TFLKAARCNK RLKIYIIFEL FQNKNIMKYF PSLVNYINSF HFDVSNEEII KNVINNIYFK
EEDESPISSI NNNNNNKVED DCNQDIKIKG DQETNEFIDD EKIKTKRKCS QEKTIQEIKK
YKLKKFLHFY AELHKKCNYE EGRGYDIDEQ NDYNIDEKDF MNDYNDNNNN NNDNLFRRSF
VKNEMMSVNH TSDDVYDEKI IRNCLMSSLP SFTLNDEITN LSYNGKYQYY EDYLCSKKKD
EEDLNFKYYN MDDVFYKMEY LIHNYFYLKR SDFDNLIDSL FQPYLCRVSS GTNNLINMNN
LMNKFLNNGF SNMIFTGAKG SKVNYSMICG MLDQQYLEGK RVPRMRSGKT LPSFHRYDYG
ARSCGLITDC FLEGLRPQEY FFHCMSGREG LIDTAVKTAK SGYIQRCLIK CMESVILHYD
GTVRNEDNSI IQFLYGEDGI DPSKTAYLDL SKDLLHNYHL SFSKYLNNNM HSKILNNQEL
FLKHEKDNDT KDNEEPLISK YNPYTYIGSV SDKFNNKLNN TLLWNDLNFP EYENVPMNFD
TLSSSLLKSK YYNSLCNPGE SIGILVAQSF GEPATQMTLN TFHLAGTENV TMGIPRLKEI
FLTSKLTSKP MIYVPIKLQV DNLKNDANKM KNYITSIADK ILSSYKSIFL TDVIYGIGVD
RKIILKENQN EQKHTINLSD IINMNDEELS GDTQLAKINN VLKNCNINFD MKKEWNYEII
IQFENLYHFC NINKHLTISF ILYKVVNALL NSVLNKVHET FVFHNLINMN SLNHEYYDEL
YDFISKKMSE EFNFNMDKYE YKDDEHQINA KLKFMEKENE RYDSKRGTNN NISGEYQNAS
HTIASHMEDD SPMKSYNDIS NKENMSPYDD GKGKDGDRDQ DDMSDIELKD NSEKNSNSDQ
ASKNADSDTD EEEEDDELKS EKEKEEDEKE YDEEGESDTN SKIDSDHKSD SDNKSDSDNK
SDSDHKSDSD HKSDSDHKSD SDHKSDSDNK NDSDNKNDSD IDSDSESEMV SSNKKEIINI
NNKDNYYTNR NSSNESKLSE CSNTKGSTVN YFSSETSATH HILVDEEESG IFPNLKNKKL
NNMNDNKNMS STTVSSSLSS SSLSTPLNKK NIEDDEHINN IHFIEKNKYN EEMDNKEEFI
TKSFTRLSYD YKNNINLISS DDDQENIEEN EEGQKMKKSE QRYVKNIIDK IKSSLLCFIK
NIHFSPVTWI LKLNIGWDIN FFPYPIDFLN HIKSEINKEV LFKVKDLNNP KILKGKDITH
SGAEYELQIE GKNIYKLYNI KDKYIDKTKL YCNDIYAIVK TYGIEAGRLC ITKELKKVFD
AYGIQIDFRH LSFISDFMTH TGDLKAFNRH GLGYFRNVFH KMSFECATNF LIQGCIHNSI
DYLSTASSSL FFGKHIKVGT NLADIVTCID KQNL
//