ID Q8I4C3_CAEEL Unreviewed; 837 AA.
AC Q8I4C3;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2006, sequence version 3.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=anoh-2 {ECO:0000313|EMBL:CAD56259.3,
GN ECO:0000313|WormBase:Y57G11C.37a};
GN ORFNames=CELE_Y57G11C.37 {ECO:0000313|EMBL:CAD56259.3}, Y57G11C.37
GN {ECO:0000313|WormBase:Y57G11C.37a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD56259.3, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAD56259.3, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD56259.3,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; BX284604; CAD56259.3; -; Genomic_DNA.
DR RefSeq; NP_001255821.1; NM_001268892.1.
DR AlphaFoldDB; Q8I4C3; -.
DR SMR; Q8I4C3; -.
DR TCDB; 1.A.17.1.10; the calcium-dependent chloride channel (ca-clc) family.
DR EnsemblMetazoa; Y57G11C.37a.1; Y57G11C.37a.1; WBGene00013326.
DR EnsemblMetazoa; Y57G11C.37a.2; Y57G11C.37a.2; WBGene00013326.
DR UCSC; Y57G11C.37; c. elegans.
DR AGR; WB:WBGene00013326; -.
DR WormBase; Y57G11C.37a; CE40485; WBGene00013326; anoh-2.
DR GeneTree; ENSGT00940000157019; -.
DR HOGENOM; CLU_006685_2_1_1; -.
DR OrthoDB; 2875518at2759; -.
DR PhylomeDB; Q8I4C3; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00013326; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; Q8I4C3; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF51; ANOCTAMIN-8; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Proteomics identification {ECO:0007829|EPD:Q8I4C3,
KW ECO:0007829|PeptideAtlas:Q8I4C3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 229..256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 268..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 354..376
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 388..407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 435..458
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 686..703
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 218..756
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 511..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 96754 MW; E1AD613E1AE80855 CRC64;
MATLHNKFGA IIQDGIVEGQ RFALSSDLWR YASTSTHCDL LITMQFSNDD VENKTSVMWL
VQQMREHEPN LRIEVRYHRL NSCYAIYLTA DYKTLLKGAE LCHIKKAIKS KFGGGMRDFS
FEEAQFFSGV EGKNTFLSPM ERTIIVKQMM DMMRAGKGGL SLKLPRRTIT FTEGTAIVPR
LISMNVVQNV SALHNTEFLK HLQQKWVFSI DEQPIDQVKD YFGTEIAMYF AWLGHMTTAL
WFPSLLGILM WFLGGFKYKN SPGDKQDLYQ LISDICFVLF AFFNCIWSTI YLEWWKRVQA
ELAFKWGTYD ATQDSYLQDP RPAFQGDYLA PNPVSGRLEP FYPAWKHTVM RYVITYPITF
LCVVGMFAAM LAIFTVQDLA DFYFGDSWML SWLCYFPMIF YALMIVISDK IYRRLALILN
DLENYRTDDE YEDFLITKIV LFQFVTAFGS LFYIAFVLRD MKRLQETLAT LLITRQVTQN
IMETVVPFMI EKLKLSSLTY KMTRSMSDGT LRRHVENVRN KRQNSVEQEE EEKSPRTPTT
SFFTLGSPTT PETEVRQRKP NSDGTLATGD FKQLRTLSSI FREDFSLKTE RLPLPEFKPC
TDSNPELTQA ELESVMSVYA RPLDDFLEMF IQFGYVLLFS PAFPLAAVCA LINNLIEIRV
DAFKLCNTVQ RPFGRRVKDI GAWQKAMEIL GILGVIVNCA LIGQSGLVQR IWPDLSWGGQ
ILIIVVLEHV ILASKMIIDI LVPDVPHWVR IETAKQEHFR REAFKRESRL LSFTQTPPTD
QIGQQSQNEP ISPSESTSRF NRLDQINRSK RRSITPMVRL SSFTRKPRKE AQDNCID
//
