ID Q8I4L4_CAEEL Unreviewed; 503 AA.
AC Q8I4L4;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 153.
DE SubName: Full=BTB domain-containing protein {ECO:0000313|EMBL:CAD56572.1};
GN Name=shw-1 {ECO:0000313|EMBL:CAD56572.1,
GN ECO:0000313|WormBase:F14F11.1d};
GN ORFNames=CELE_F14F11.1 {ECO:0000313|EMBL:CAD56572.1}, F14F11.1
GN {ECO:0000313|WormBase:F14F11.1d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD56572.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAD56572.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD56572.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX284602; CAD56572.1; -; Genomic_DNA.
DR RefSeq; NP_871939.1; NM_182139.1.
DR AlphaFoldDB; Q8I4L4; -.
DR SMR; Q8I4L4; -.
DR EnsemblMetazoa; F14F11.1d.1; F14F11.1d.1; WBGene00008819.
DR GeneID; 174331; -.
DR UCSC; F14F11.1h; c. elegans.
DR AGR; WB:WBGene00008819; -.
DR WormBase; F14F11.1d; CE32378; WBGene00008819; shw-1.
DR GeneTree; ENSGT00940000172965; -.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00008819; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; Q8I4L4; baseline and differential.
DR GO; GO:0043679; C:axon terminus; IBA:GO_Central.
DR GO; GO:0032590; C:dendrite membrane; IBA:GO_Central.
DR GO; GO:0032809; C:neuronal cell body membrane; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005251; F:delayed rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18416; BTB_Shaw-like; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003974; K_chnl_volt-dep_Kv3.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF252; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01498; SHAWCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 303..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..115
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 460..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 57253 MW; 17234B528418C31F CRC64;
MVNLQRKESW MDTEHRVILN VGGIRHETYS HVLKKIPATR LSRLTPNLAN YDPVLNEYFF
DRHPGVFSMI LNYYRTGKLH YPTNVCGPLF EEELEFWGLD ANQVEPCCWM TYTQHRDTQD
TLAVIESLDL DGDPPTQEEI AKKFGWEDDY YTGNMSQWQR LKPRVWALFD EPWSSKYARV
ISSLSVAFIL ASTCSFILKT DPSFQIPDID VFYSLRVVDE GGFKNYHKTI GTDKPVTSPH
PNFFYVDLIC NIWFTIELLI RSLFCPSFHK FVRSPLTIID VISTGAFFFE SLLHAILIQT
GSLVTLDFLS MICVLRLFKL TQHFSGLKIL IQTFKASAQE LFLLVFFVIL AIVIFAALVY
YAERSQLNKD NQFTSIPLGL WWSLVTISTV GFGDMVPKTY LGMLVGSLCA LMGVLTIALP
VPVIVSNFSN LYSHSQARAK LPKKRRRVLQ AHEVKPALLG VKQHHGKHRK KSSSATFNQP
PANFKNANGG PSMHDNSASK LMA
//
