ID Q8I4U9_PLAF7 Unreviewed; 289 AA.
AC Q8I4U9;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Bax inhibitor 1, putative {ECO:0000313|EMBL:CZT99640.1};
GN ORFNames=PF3D7_1248500 {ECO:0000313|EMBL:CZT99640.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT99640.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT99640.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000256|RuleBase:RU004379}.
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DR EMBL; LN999947; CZT99640.1; -; Genomic_DNA.
DR RefSeq; XP_001350869.1; XM_001350833.1.
DR AlphaFoldDB; Q8I4U9; -.
DR SMR; Q8I4U9; -.
DR STRING; 36329.Q8I4U9; -.
DR PaxDb; 5833-PFL2325c; -.
DR EnsemblProtists; CZT99640; CZT99640; PF3D7_1248500.
DR GeneID; 811517; -.
DR KEGG; pfa:PF3D7_1248500; -.
DR VEuPathDB; PlasmoDB:PF3D7_1248500; -.
DR HOGENOM; CLU_058671_3_1_1; -.
DR InParanoid; Q8I4U9; -.
DR OMA; FTGWYVY; -.
DR OrthoDB; 377780at2759; -.
DR PhylomeDB; Q8I4U9; -.
DR Reactome; R-PFA-6798695; Neutrophil degranulation.
DR Proteomes; UP000001450; Chromosome 12.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR CDD; cd10428; LFG_like; 1.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR PANTHER; PTHR23291:SF129; GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004379};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004379}.
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 145..164
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 225..243
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
SQ SEQUENCE 289 AA; 32275 MW; A5C0C848737608FF CRC64;
MADTNGRNSI VGQNYGAAYN QGGYNYSQNK DKENYDKSNS GQKGYYYDAR TNITANGGLY
DEFSLNEFSS TKIRHGFIRK VYSILSLQLL LTFGCAALAV LYKPFNAFVL TYYSPLFIVG
VLLSLPIMIA LACAPHMARK YPSNYFILLS ITLGMSLIVT LASARTNSEI FFYAFGTTAV
VVIGLTIFAF QTKWDFTGWY VFLFMAFLIL IVMGIIGIFV RSKAFNLVFA GISAFILSIS
IIVDTQLIIG GKHKKYEFSV DDYIFATLAL YMDIINLFLS ILSIFSNAE
//
