ID Q8I5R2_PLAF7 Unreviewed; 120 AA.
AC Q8I5R2;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 2.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=ER membrane protein complex subunit 6 {ECO:0000256|ARBA:ARBA00020827};
GN ORFNames=PF3D7_1214400 {ECO:0000313|EMBL:CZT99305.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT99305.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT99305.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the EMC6 family.
CC {ECO:0000256|ARBA:ARBA00009436}.
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DR EMBL; LN999947; CZT99305.1; -; Genomic_DNA.
DR RefSeq; XP_001350548.2; XM_001350512.2.
DR AlphaFoldDB; Q8I5R2; -.
DR SMR; Q8I5R2; -.
DR STRING; 36329.Q8I5R2; -.
DR PaxDb; 5833-PFL0695c; -.
DR EnsemblProtists; CZT99305; CZT99305; PF3D7_1214400.
DR GeneID; 811192; -.
DR KEGG; pfa:PF3D7_1214400; -.
DR VEuPathDB; PlasmoDB:PF3D7_1214400; -.
DR HOGENOM; CLU_110781_3_0_1; -.
DR InParanoid; Q8I5R2; -.
DR OMA; MKANFEW; -.
DR OrthoDB; 4927at2759; -.
DR PhylomeDB; Q8I5R2; -.
DR Proteomes; UP000001450; Chromosome 12.
DR GO; GO:0072546; C:EMC complex; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR InterPro; IPR008504; Emc6.
DR InterPro; IPR029008; EMC6-like.
DR PANTHER; PTHR20994:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6; 1.
DR PANTHER; PTHR20994; UNCHARACTERIZED; 1.
DR Pfam; PF07019; EMC6; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 120 AA; 13738 MW; 119C131341254FD5 CRC64;
MEGDEKQGNS KNILDSKLLG NKKYDENSLK HNKHSLILSK QFYGIISGIT VGILGVQGIL
GFLLFILFTL IGTCITFFHI RKKFGSYFLK KSDLFFGDFF SGLISFILFW TLSYDIIYIF
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