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Database: UniProt
Entry: Q8I9B4
LinkDB: Q8I9B4
Original site: Q8I9B4 
ID   MT4_DROME               Reviewed;          44 AA.
AC   Q8I9B4; Q1WW94; Q86B88;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   12-SEP-2018, entry version 72.
DE   RecName: Full=Metallothionein-4;
DE            Short=MT-4;
DE   AltName: Full=Metallothionein D;
GN   Name=MtnD; ORFNames=CG33192;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Canton-S;
RX   PubMed=12505988; DOI=10.1093/emboj/cdg012;
RA   Egli D., Selvaraj A., Yepiskoposyan H., Zhang B., Hafen E.,
RA   Georgiev O., Schaffner W.;
RT   "Knockout of 'metal-responsive transcription factor' MTF-1 in
RT   Drosophila by homologous recombination reveals its central role in
RT   heavy metal homeostasis.";
RL   EMBO J. 22:100-108(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A.,
RA   Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein binds cations of several transition
CC       elements. Thought to be involved in metal ion homeostasis (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: All cysteine residues are arranged in C-X-C groups. These
CC       are thought to be the metal-binding sites in other
CC       metallothioneins.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 5
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABE01242.1; Type=Erroneous termination; Positions=32; Note=Translated as Lys.; Evidence={ECO:0000305};
DR   EMBL; AF546903; AAN73050.1; -; mRNA.
DR   EMBL; AE014297; AAO41579.2; -; Genomic_DNA.
DR   EMBL; BT025012; ABE01242.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_788695.2; NM_176518.2.
DR   UniGene; Dm.14852; -.
DR   SMR; Q8I9B4; -.
DR   STRING; 7227.FBpp0300409; -.
DR   PaxDb; Q8I9B4; -.
DR   PRIDE; Q8I9B4; -.
DR   EnsemblMetazoa; FBtr0308064; FBpp0300409; FBgn0053192.
DR   GeneID; 326270; -.
DR   KEGG; dme:Dmel_CG33192; -.
DR   CTD; 326270; -.
DR   FlyBase; FBgn0053192; MtnD.
DR   eggNOG; ENOG410KBV5; Eukaryota.
DR   eggNOG; ENOG4110MWJ; LUCA.
DR   InParanoid; Q8I9B4; -.
DR   PhylomeDB; Q8I9B4; -.
DR   GenomeRNAi; 326270; -.
DR   PRO; PR:Q8I9B4; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0053192; Expressed in 16 organ(s), highest expression level in adult midgut (Drosophila).
DR   Genevisible; Q8I9B4; DM.
DR   GO; GO:0046872; F:metal ion binding; IDA:FlyBase.
DR   GO; GO:0055065; P:metal ion homeostasis; IMP:FlyBase.
DR   GO; GO:0046688; P:response to copper ion; IDA:FlyBase.
DR   GO; GO:0010038; P:response to metal ion; IDA:FlyBase.
DR   InterPro; IPR000966; Metalthion_5.
DR   Pfam; PF02067; Metallothio_5; 1.
DR   PRINTS; PR00872; MTDIPTERA.
PE   3: Inferred from homology;
KW   Cadmium; Complete proteome; Copper; Metal-binding; Reference proteome;
KW   Zinc.
FT   CHAIN         1     44       Metallothionein-4.
FT                                /FTId=PRO_0000197357.
SQ   SEQUENCE   44 AA;  4545 MW;  34F0847BFA8BCC7B CRC64;
     MGCKACGTNC QCSATKCGDN CACSQQCQCS CKNGPKDKCC STKN
//
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