ID Q8IAR6_PLAF7 Unreviewed; 481 AA.
AC Q8IAR6;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=26S proteasome regulatory subunit RPN10, putative {ECO:0000313|EMBL:CAD51294.1};
GN ORFNames=PF3D7_0807800 {ECO:0000313|EMBL:CAD51294.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51294.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
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DR EMBL; AL844507; CAD51294.1; -; Genomic_DNA.
DR RefSeq; XP_001349445.1; XM_001349409.1.
DR AlphaFoldDB; Q8IAR6; -.
DR SMR; Q8IAR6; -.
DR IntAct; Q8IAR6; 2.
DR STRING; 36329.Q8IAR6; -.
DR PaxDb; 5833-PF08_0109; -.
DR EnsemblProtists; CAD51294; CAD51294; PF3D7_0807800.
DR GeneID; 2655309; -.
DR KEGG; pfa:PF3D7_0807800; -.
DR VEuPathDB; PlasmoDB:PF3D7_0807800; -.
DR HOGENOM; CLU_654665_0_0_1; -.
DR InParanoid; Q8IAR6; -.
DR OMA; CLDIISY; -.
DR OrthoDB; 169547at2759; -.
DR PhylomeDB; Q8IAR6; -.
DR Reactome; R-PFA-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-PFA-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR Reactome; R-PFA-5689603; UCH proteinases.
DR Reactome; R-PFA-5689880; Ub-specific processing proteases.
DR Reactome; R-PFA-68949; Orc1 removal from chromatin.
DR Reactome; R-PFA-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-PFA-8951664; Neddylation.
DR Reactome; R-PFA-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-PFA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000001450; Chromosome 8.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd01452; VWA_26S_proteasome_subunit; 1.
DR Gene3D; 6.10.140.100; -; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR014624; 26S_protsm_s5a.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10223; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR10223:SF0; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF13519; VWA_2; 1.
DR PIRSF; PIRSF036805; 26S_protsm_s5a; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 4: Predicted;
KW Proteasome {ECO:0000313|EMBL:CAD51294.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 7..115
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
FT REGION 279..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 55067 MW; B65AE4015AC76177 CRC64;
MSNIEATIIC IDNSDYNRNE DIVPNRFLSQ IDCVNVLCCN KTSLHYKNNI GILMMAGDKI
KVKVSLTNDI GQLLSCIHDI KLDGTCDIIR SLLIAQLALK HRVDKNLDQK IILFIGSPFH
VNEKQLINTG KQLKKNNISV DIISFGNIDK NRDKLMMLFE SVNNNDNCRF IECPEYENNL
SKFVLNSFLN NNDFNIGNIQ DDDQLLNAMQ LSLEESQHMD KNLNTTNNIN TGSNHHTNNI
TTNNNDLPTI EEIENMKDID NELKEALILS LREYTEKNKL ENKDTTSNNN NNNNESNNNN
NESNNNNNES NNNNNESNNN NNESNNNNNE SNNNNNESNN NNNGNTCGNN NNNSLNFYKK
DDNFALVNES YKNNFDKNDE NKLETSKEKK ENESYEKVFK IDKEENMEDT SKDIINEHIY
KDIQHNDENN NVINQGEEKE QSASSLIQDP SYISNILGKI NPNVNVFDKK EGDSDKEKNK
E
//
