ID Q8IAT4_PLAF7 Unreviewed; 1259 AA.
AC Q8IAT4;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=JmjC domain-containing protein, putative {ECO:0000313|EMBL:CAD51276.1};
GN ORFNames=PF3D7_0809900 {ECO:0000313|EMBL:CAD51276.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51276.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL844507; CAD51276.1; -; Genomic_DNA.
DR RefSeq; XP_001349427.1; XM_001349391.1.
DR AlphaFoldDB; Q8IAT4; -.
DR IntAct; Q8IAT4; 12.
DR STRING; 36329.Q8IAT4; -.
DR PaxDb; 5833-MAL8P1-111; -.
DR EnsemblProtists; CAD51276; CAD51276; PF3D7_0809900.
DR GeneID; 2655235; -.
DR KEGG; pfa:PF3D7_0809900; -.
DR VEuPathDB; PlasmoDB:PF3D7_0809900; -.
DR HOGENOM; CLU_265056_0_0_1; -.
DR InParanoid; Q8IAT4; -.
DR OMA; TNDMTND; -.
DR OrthoDB; 48111at2759; -.
DR PhylomeDB; Q8IAT4; -.
DR Proteomes; UP000001450; Chromosome 8.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0034647; F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.650; Cupin; 3.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR004198; Znf_C5HC2.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF113; PROTEIN JUMONJI; 1.
DR Pfam; PF02373; JmjC; 2.
DR Pfam; PF02928; zf-C5HC2; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 303..344
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 660..973
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 100..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 149450 MW; 2C0890C840B4CBF9 CRC64;
MDKQITGIKK RKRNREFVLS CDDDDDVNYI DTGKKTNGCI NKVDKKLLNQ KDLYQIKKVY
DTRNKSFLKN NEINYKNIEE DNYTYIENIF DEEEFEEWKN GKKKNDDSEQ ANDVFDDPIR
GNINDMTNDI TNDMTNDMTN DMTNDITNDM TNDITNDITN DISNDITNED ELIDISNNKY
KKSIYKRGID DTNMNSKKSV SMCSEYKGKC VVNNELNNIQ NEHNNVNNFE RVLGNLPQRQ
HMSNISNGNN NNDNDNNNNN NNIINNKNNN NNINNNNNNN NCRNNNCSNN SDDENIYKRI
KEIPEINTTM EEMTNPMLFF EKYNYMGLKY GALKVIPPSF FSPQFNSYYL NIKFNIRRQM
INELKNGKEF DHPDEYWTLY EMYKYNEMLQ NKYLSSDNKF DLDNIEKTYW DIINNKKNED
VISVYGADLP VKRNQPTCIF PNKYKSNISM TKNTSNGIIK SGTNKIKRKN TSNKINENNK
NEEPINNNKK KNKKNKKHNN IYNNSVQNNI DEIVIDSDED EHVKSVKKIA CCPKKIKENQ
TKASYTISKE KVLQKDTNEI IEVINILDTD NEEDHGDNKI ESHVIKSNGN NIKQNKNNTN
YYNIKECDNN NNNNNMHNDK RCDHNINNTV VCKKNDNVRK DYNFLERKNN YFCEINDIIS
NISENMNIKS LPFIRGSMLR NIDILIEGVN IPWLYIGTLF STFCWHTEDN YFASINYQHW
GQPKIWYVIP PHYSDKVEDV IYEYLKENSK ININNNKGGT SYMGGGRRRR GKYFRKRRFS
MPLHNRNNRK SSNDITNEMN VKNNSTNIDI DINSNSNTNN NNNNNNNNNH NYYNNRNNSL
NLYNRNNNEK DYIYFEADKN NKYNFLNVNI NDVDLIYTDP YLKYKNVDKD EIDSKKENNK
NKIYKLTIQI PVEVFLKNNI PVYKNIQRKN EFIFLWPKTF HGGFNSGYNC NEACNIAPTF
WLFFGLQSYY NYKYYRNTCI SIHFILFSNL LHFHEYSFSQ LKHIIYSLRY ILLDEHRFFC
ENQSMYIDLN LQHDVLLNKK IVNYSNFVSL DLVKIFYNFE KHKNSHFFQS VKSKLQFFYK
DCDACNSPTF NSAVICPHSN DIVCIHCYDE HACNCKYRVV LKRYTLLEMM KVLKLLIHYA
NKIRKSDEKE INFDDMPNYN SMKFFEEQNS FKLFNLIRQN KKRNTPTLYA DLENYCAKKL
MNIEKFKRPN HNQNNNIILD DYYTSVSHFK TKLTLKYFFL TYEEEKEENS MQILPKIVS
//
