ID Q8IDW3_PLAF7 Unreviewed; 632 AA.
AC Q8IDW3;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE RecName: Full=tryptophan--tRNA ligase {ECO:0000256|ARBA:ARBA00013161};
DE EC=6.1.1.2 {ECO:0000256|ARBA:ARBA00013161};
DE AltName: Full=Tryptophanyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030268};
GN ORFNames=PF3D7_1336900 {ECO:0000313|EMBL:CAD52506.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD52506.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0007829|PDB:4J75, ECO:0007829|PDB:4J76}
RP X-RAY CRYSTALLOGRAPHY (2.34 ANGSTROMS) OF 229-632.
RX PubMed=23665145; DOI=10.1016/j.molbiopara.2013.04.007;
RA Koh C.Y., Kim J.E., Napoli A.J., Verlinde C.L., Fan E., Buckner F.S.,
RA Van Voorhis W.C., Hol W.G.;
RT "Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA
RT synthetase and its potential as a target for structure-guided drug
RT design.";
RL Mol. Biochem. Parasitol. 189:26-32(2013).
RN [4] {ECO:0007829|PDB:4JFA}
RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 228-632.
RX PubMed=23776638; DOI=10.1371/journal.pone.0066224;
RA Khan S., Garg A., Sharma A., Camacho N., Picchioni D., Saint-Leger A.,
RA Ribas de Pouplana L., Yogavel M., Sharma A.;
RT "An appended domain results in an unusual architecture for malaria parasite
RT tryptophanyl-tRNA synthetase.";
RL PLoS ONE 8:e66224-e66224(2013).
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594}.
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DR EMBL; AL844509; CAD52506.1; -; Genomic_DNA.
DR RefSeq; XP_001350097.1; XM_001350061.1.
DR PDB; 4J75; X-ray; 2.40 A; A/B=229-632.
DR PDB; 4J76; X-ray; 2.34 A; A/B=229-632.
DR PDB; 4JFA; X-ray; 2.60 A; A/B/C/D=228-632.
DR PDBsum; 4J75; -.
DR PDBsum; 4J76; -.
DR PDBsum; 4JFA; -.
DR AlphaFoldDB; Q8IDW3; -.
DR SMR; Q8IDW3; -.
DR STRING; 36329.Q8IDW3; -.
DR PaxDb; 5833-PF13_0205; -.
DR EnsemblProtists; CAD52506; CAD52506; PF3D7_1336900.
DR GeneID; 814174; -.
DR KEGG; pfa:PF3D7_1336900; -.
DR VEuPathDB; PlasmoDB:PF3D7_1336900; -.
DR HOGENOM; CLU_450968_0_0_1; -.
DR InParanoid; Q8IDW3; -.
DR OMA; WNINCNR; -.
DR OrthoDB; 540846at2759; -.
DR PhylomeDB; Q8IDW3; -.
DR BRENDA; 6.1.1.2; 4889.
DR Proteomes; UP000001450; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004830; F:tryptophan-tRNA ligase activity; ISS:GeneDB.
DR GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IDA:GeneDB.
DR Gene3D; 3.30.54.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR InterPro; IPR002306; Trp-tRNA-ligase.
DR NCBIfam; TIGR00233; trpS; 1.
DR PANTHER; PTHR10055:SF1; TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10055; TRYPTOPHANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00579; tRNA-synt_1b; 1.
DR PRINTS; PR01039; TRNASYNTHTRP.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF55186; ThrRS/AlaRS common domain; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4J75, ECO:0007829|PDB:4J76};
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CAD52506.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
SQ SEQUENCE 632 AA; 73100 MW; B3E9DE08A4BF0C51 CRC64;
MDKLKTIYLD SALSIIKGAL CIILQIPTSR TTESVKKKAN NVGVITVKSI LSEPTIHQYD
DIKKLIKNKL QECVPFYNYN MNRSFAEKIY GDCIYDNYGL SKEINEINLI ILEEWNINCN
KNRVLKNTGL IKEITINQFK YSTNKESLEV HFAVSPKYTF EELSTMYKNE KGLYEFLLSP
IIKIICNEND KKLLDNMNEE CTYLNAEDIL PKNKVLPPSG IENIDYERSK DVTPWDVNIN
NEEGINYNKL IKEFGCSKIT ENHIKRIEKL TNSKAHHFIR RGIFFSHRDL DFLLNYYEQH
KCFYIYTGRG PSSLSMHLGH LIPFYFCKYL QEAFNVPLVI QLSDDEKYLF NQNYSLEYIN
TLTNENVKDI ISVGLNPELT FIFKNTEYAG YLYPTVLSIH KKTTLNQSMN VFGFNHSDNI
GKISYPSFQI APCFSQCFPN FLGKNIPCLV PQGIDQDPYF RLSRDIAVKM ALHKPVVVHS
VFMPGLQGVN SKMSSTKKKK DDNGKSNSTF DHNNSVIFLT DTPEQIKNKI NKYAFSGGGT
TIQEHREKGG NLDKDISYQY LRYLLEDDNK LNEIGEKYKK GEMLSGEIKK ILIDVLTELV
LKHQEKKKSL TDEEISYFFD PNKPSLQKFK NM
//
