GenomeNet

Database: UniProt
Entry: Q8IEG9_PLAF7
LinkDB: Q8IEG9_PLAF7
Original site: Q8IEG9_PLAF7 
ID   Q8IEG9_PLAF7            Unreviewed;       408 AA.
AC   Q8IEG9;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   25-OCT-2017, entry version 84.
DE   SubName: Full=Lipoate-protein ligase 1 {ECO:0000313|EMBL:CAD52290.1};
DE            EC=2.7.7.63 {ECO:0000313|EMBL:CAD52290.1};
GN   ORFNames=PF3D7_1314600 {ECO:0000313|EMBL:CAD52290.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD52290.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000213|PDB:5T8U}
RP   X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) OF 20-407.
RX   PubMed=28543853; DOI=10.1002/prot.25324;
RA   Guerra A.J., Afanador G.A., Prigge S.T.;
RT   "Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from
RT   Plasmodium falciparum.";
RL   Proteins 0:0-0(2017).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AL844509; CAD52290.1; -; Genomic_DNA.
DR   RefSeq; XP_001349882.1; XM_001349846.1.
DR   PDB; 5T8U; X-ray; 2.32 A; A/B=20-407.
DR   PDBsum; 5T8U; -.
DR   ProteinModelPortal; Q8IEG9; -.
DR   SMR; Q8IEG9; -.
DR   EnsemblProtists; CAD52290; CAD52290; PF3D7_1314600.
DR   GeneDB; PF3D7_1314600.1:pep; -.
DR   GeneID; 814061; -.
DR   KEGG; pfa:PF13_0083; -.
DR   EuPathDB; PlasmoDB:PF3D7_1314600; -.
DR   HOGENOM; HOG000260594; -.
DR   InParanoid; Q8IEG9; -.
DR   KO; K03800; -.
DR   OMA; EDWIHDH; -.
DR   PhylomeDB; Q8IEG9; -.
DR   Reactome; R-PFA-389661; Glyoxylate metabolism and glycine degradation.
DR   Proteomes; UP000001450; Chromosome 13.
DR   GO; GO:0005739; C:mitochondrion; IDA:GeneDB.
DR   GO; GO:0016979; F:lipoate-protein ligase activity; IDA:GeneDB.
DR   GO; GO:0006629; P:lipid metabolic process; ISS:GeneDB.
DR   GO; GO:0009249; P:protein lipoylation; IDA:GeneDB.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR019491; Lipoate_protein_ligase_C.
DR   InterPro; IPR004562; LipoylTrfase_LipoateP_Ligase.
DR   PANTHER; PTHR12561; PTHR12561; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF10437; Lip_prot_lig_C; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:5T8U};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Ligase {ECO:0000313|EMBL:CAD52290.1};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:CAD52290.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transferase {ECO:0000313|EMBL:CAD52290.1}.
FT   DOMAIN       60    242       BPL/LPL catalytic. {ECO:0000259|PROSITE:
FT                                PS51733}.
FT   COILED      235    262       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   408 AA;  47943 MW;  1FE5C6DC4E619D27 CRC64;
     MKRIFRLVRR CHYSTEKRTN GPLVLVSNNQ NIHFNLSLEN FLLNNYNDLL KYLNINTIEK
     FNEPILFLWR NNRSIIIGKN QNIWSECNLK NIKEDGVLVA RRFTGGGAVY HDLGNVCFTF
     LNNNINTSSN FLIILNTLKN HFNIEAKTQG RNDITVNDQK CSGSAFKKIK DVFLHHGTIL
     INLEKNILNK YLTPDKIKYI KHGVSSVNAR TINLSEINNN ITCENLCIAL IKEFTKFYEQ
     NYKENINNIK NLENNINNSN FQNKEQININ NTNENNLINN TNIIPNDITV HYIDQNNNIT
     KNPEFLKYYN LLKDWDWCYG KTPKFQNHIW KQFTFGKLEL FFNVSNGFIK DGNIFSDCLD
     INLIDHLKSI FNNDIKYSKE DISIFFKKLN VENKNYLDEV RSWILQEL
//
DBGET integrated database retrieval system