ID Q8IIC9_PLAF7 Unreviewed; 555 AA.
AC Q8IIC9;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE RecName: Full=Eukaryotic peptide chain release factor GTP-binding subunit {ECO:0000256|ARBA:ARBA00015765};
DE AltName: Full=ERF2 {ECO:0000256|ARBA:ARBA00030845};
DE AltName: Full=Polypeptide release factor 3 {ECO:0000256|ARBA:ARBA00029585};
DE AltName: Full=Translation release factor 3 {ECO:0000256|ARBA:ARBA00030210};
GN ORFNames=PF3D7_1123400 {ECO:0000313|EMBL:CZT98896.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT98896.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT98896.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
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DR EMBL; LN999945; CZT98896.1; -; Genomic_DNA.
DR RefSeq; XP_001347916.1; XM_001347880.1.
DR AlphaFoldDB; Q8IIC9; -.
DR SMR; Q8IIC9; -.
DR IntAct; Q8IIC9; 1.
DR STRING; 36329.Q8IIC9; -.
DR PaxDb; 5833-PF11_0245; -.
DR EnsemblProtists; CZT98896; CZT98896; PF3D7_1123400.
DR GeneID; 810792; -.
DR KEGG; pfa:PF3D7_1123400; -.
DR VEuPathDB; PlasmoDB:PF3D7_1123400; -.
DR HOGENOM; CLU_007265_3_8_1; -.
DR InParanoid; Q8IIC9; -.
DR OMA; GKMESGC; -.
DR OrthoDB; 5477300at2759; -.
DR PhylomeDB; Q8IIC9; -.
DR Reactome; R-PFA-72764; Eukaryotic Translation Termination.
DR Reactome; R-PFA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-PFA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000001450; Chromosome 11.
DR GO; GO:0005853; C:eukaryotic translation elongation factor 1 complex; ISS:GeneDB.
DR GO; GO:0018444; C:translation release factor complex; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; ISS:GeneDB.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; ISS:GeneDB.
DR GO; GO:0003747; F:translation release factor activity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR GO; GO:0006414; P:translational elongation; ISS:GeneDB.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03704; eRF3_C_III; 1.
DR CDD; cd04089; eRF3_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF36; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:CZT98896.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:CZT98896.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 117..352
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 21..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 62881 MW; D7B9D98FA90D1625 CRC64;
MNEPFSFNVN APSYYPGMKY KGAGAEEDDE NNSNLDNTNN ENNINMNNDV NNDLDKIKEE
EDINGSEIVE DENVNDIEEK ISKLVLNDDN DIMKDDVEEL QEKVEDKKIK MAEVDPRPHL
NIIFIGHVDA GKSTACGNIL YILGYVDDRT IEKYEREAKE KSRESWFLAF IMDINEEERQ
KGKTVEVGRA HFETKDRRFT ILDAPGHKNF IPNMISGAAQ ADIGVLIISA RKGEFETGFE
RGGQTREHTL LARTLGINQL IVAINKMDDP TCNWSESRYE EIQKKITPYI KSCGYNINKD
VFFVPISGLT GQNLSEHVSD KNSKIYDPRA SWYDLSKPTL FNILNSLPPP PWDENGPLRI
PLLEGYKDNG IIAIGKIESG TLYGNNMNCT LMPNKVKVKV MNVFLEDDEV PYAKPGENVR
VRLFGVEEDQ ISKGFVLCDS INLCSVVHEF IGRVAIVELL EHKPIITAGY FCIFHAHTAC
EEIQFVEMLE VIDKKSKKKK TKPKFIKSDC IVTAHFLLSN PVCVEVYDNL PQLGRFTLRD
QGKTIAIGKI LELKV
//
