ID Q8IIT6_PLAF7 Unreviewed; 1024 AA.
AC Q8IIT6;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=DNA replication ATP-dependent helicase/nuclease DNA2, putative {ECO:0000313|EMBL:CZT98733.1};
DE EC=3.6.4.12 {ECO:0000313|EMBL:CZT98733.1};
GN ORFNames=PF3D7_1106700 {ECO:0000313|EMBL:CZT98733.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT98733.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT98733.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
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DR EMBL; LN999945; CZT98733.1; -; Genomic_DNA.
DR RefSeq; XP_001347754.1; XM_001347718.1.
DR AlphaFoldDB; Q8IIT6; -.
DR SMR; Q8IIT6; -.
DR PaxDb; 5833-PF11_0078; -.
DR EnsemblProtists; CZT98733; CZT98733; PF3D7_1106700.
DR GeneID; 810630; -.
DR KEGG; pfa:PF3D7_1106700; -.
DR VEuPathDB; PlasmoDB:PF3D7_1106700; -.
DR HOGENOM; CLU_315356_0_0_1; -.
DR InParanoid; Q8IIT6; -.
DR OMA; IFCVHGP; -.
DR OrthoDB; 170190at2759; -.
DR PhylomeDB; Q8IIT6; -.
DR Proteomes; UP000001450; Chromosome 11.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:CZT98733.1};
KW Hydrolase {ECO:0000313|EMBL:CZT98733.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 355..589
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 598..688
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT DOMAIN 844..986
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 660..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 459..486
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 660..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 120147 MW; BA4BDB10CEC2BD8C CRC64;
MMEKINEEQK LLDIFIKLIK LENIYELIEN KLCYEYLNKD ELIEKGILLN NLTIKGITKY
DEKNNSYILK LVKKKKHIDT NDLSDDENLD NFPQHMFSKG SIVHFARKRK KYILGSRNDQ
TLSYHINDNN KKNCDDKNNT KNNINNTSII NDVVNIYVCS VHKIKKNQIS LILRNSTELC
KELNVSNMFM LCDKGYFDVC LVSSDISAQR QINAINIMKS NLDNESDILK ILFFNKSPSQ
SSILKRIINI FDEYDKSESK DYNDVYDNIN NNICNNIIDN VGDNNNNNYF NPCCCDKNLE
KDIHTKKEDA VEEEKNMNTY FKSTHLCTHN NIKLSNDVLN NYIYKCDKIN WGIKNLNINQ
KKAVYSCIFS NDIFCIHGPP GTGKTTVLCE LIYQLIQRNY KILVTGPSNV SVDNILRKCV
EDLNIKNVVR IGIKSKVKKE LHNYCYDEKI KECDSYKLCE DIDNEIEKLK LEINKLKNKK
KSDNKIFIDK KQIYNLKCEI KNLNKTRKKK RNIFFKDLIN KNNVIFSTCS STSNYELNKF
VKFSNFLFDA VCIDECCQCT EPLCYIPISL SKKNVFLFGD HKQLSPLIKY NKHKNKLNIT
LFERLINKHK QNISFLLNTQ YRMNNLILLW SNKIFYEQKL VSHESCKEIT VDELFSSNRP
NQKEHIKSKV NKDNKENKEN KENRDNDKKN KNNNNKKNYN NSKKKKNANN KGTNKNHEQE
IDNHIYNQTN DIIQNYDYCP ITWIETDGFD EFLEDIDDID LMNMESKNVD INEKKNGNSK
DLKIKEKNDV DQIKCNDNNK NNDNDIINKR SSEEERKKRK ESQKDHINND LSEDSDDYNN
NMLTKLNDEE LMKMVKIDVD DILNLNNKSR SNKGEAYVIY KIIEKMIKID NINSNNICII
TPYSKQTNLL RNIFYDNIYN DQHYLSTYKN IEISTVDSFQ GREKEIVVFS LVCSNYFKNI
GFLKDYRRLN VAVTRAKRHL VIVGNSNTIS NDDVLNQLYE TVLENGKVYL VNELIDVEAV
ILNT
//