ID Q8IJH4_PLAF7 Unreviewed; 5687 AA.
AC Q8IJH4;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE SubName: Full=Dynein heavy chain, putative {ECO:0000313|EMBL:CZT98486.1};
GN ORFNames=PF3D7_1023100 {ECO:0000313|EMBL:CZT98486.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT98486.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT98486.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
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DR EMBL; LN999944; CZT98486.1; -; Genomic_DNA.
DR RefSeq; XP_001347508.1; XM_001347472.1.
DR SMR; Q8IJH4; -.
DR STRING; 36329.Q8IJH4; -.
DR PaxDb; 5833-PF10_0224; -.
DR EnsemblProtists; CZT98486; CZT98486; PF3D7_1023100.
DR GeneID; 810381; -.
DR KEGG; pfa:PF3D7_1023100; -.
DR VEuPathDB; PlasmoDB:PF3D7_1023100; -.
DR HOGENOM; CLU_000038_4_0_1; -.
DR InParanoid; Q8IJH4; -.
DR OMA; ICEHMAY; -.
DR OrthoDB; 275566at2759; -.
DR PhylomeDB; Q8IJH4; -.
DR Proteomes; UP000001450; Chromosome 10.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; ISS:GeneDB.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; ISS:GeneDB.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR GO; GO:0007017; P:microtubule-based process; ISS:GeneDB.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF36; DYNEIN HEAVY CHAIN AT 93AB, ISOFORM C; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 2.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 1574..1723
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1753..2012
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 2321..2625
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2727..2805
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 3802..4060
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 4073..4411
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 5087..5202
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 5233..5374
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 5380..5682
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 2005..2115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3033..3062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3239..3261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3678..3698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4573..4633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4840..4863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4875..4898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1464..1520
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4086..4123
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4284..4367
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2013..2092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3678..3694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4876..4898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5687 AA; 671876 MW; 136DFADD127DC99D CRC64;
MSKKNDVYEE NGEYNPKVEE LLTSALEFFN IHGLAREEVI NNIKKDENTI KLLNDFYEKN
EECLFIFNEK DCIKIYNSIL DLYKKRKNEK FLIIYKTPQS NILYLEMNND AENVIRNFLE
IFFSNFMNKN EDINSSSLLK EMKKKFNNFL LNLRIIYGET EEKLTLPYAP SEIKEENVNT
IEEYLIHFIK CYHIILRNFM NYKKKEYINC YEFLKCLKNK SEDINYLYNE IDKESFQEII
NIILEKKKNS SYKNIIENIK KEISEHKMEI LDLYTHLKPV VHFLQKLEFN KDDDIEKKYI
YITPIIHSLS ISIDKSNYLI KNCKFVFNFL SKVLINSCNQ NLNTPEIINS IYNCVDVLKI
KLYDTLNFLL NFLYIFKMYK SKNEKLQSLH EHNTYVIQRK TQIQVTSEKG NELDINMSPE
KKKNNNINID IISSYQNGNN NEENLNQEDD IKNELEEEYS YFPSISLYMY KLKILIEYLK
IYQTYMKLEK IEIPGEKGKN LTEEIHNISN DFNIINENFL DINHEILNEH EHIFINKYNI
FESRVKELNK RLICVFVYSF DNDLKKNIKL LNSFLILRDI HVIEVELIRH ASLLCQDLKK
EFILVDNLFI KNKTIIENNK KMFLEDKFQQ GQCDLDGIKN VMSNNIEEEH INKKNITGEN
IISNNIEEEH INKKNITGEN IISNNIQDDN TANTNIADET IPDVKAPSIT NNINVNINVN
INVNINVNNK MKDKLEIDKM EREIKERFED NLKRLNINKN SPLFCEVINL FTSLLKRIEQ
QYFPLKKIIK VLKFENEKTE EVKHLYKNIN EKISKYINDV SKEWFKETID VVNNFLNEYI
FKKRNDLFYV NFHPYIFMFI NNIKNFFLNN LSVNEDCLHI YNKANTFKKF INILNNITKK
YNSVLTKTLD VEKELFEEKM NNIKNRLLKG VKELKWSDDN IYEYIESVDK DMSDIYNNIS
TLHNNIVSIL NVTSNWVKKS IIEKRKRNED IYTYLNNYKN NMSILKGKLN DDFKNINMNI
KQSYDILKIK KNNIMWKNYL KFLNNIIIDK LIHLTNFLFN NLYDVMKCTK RDEQLFIIRI
NFIENKLNLD LKLTSKKTFC IETIFYKWID DFMNLCSGIR RIDIKSGDYL NEILLSLSIH
YNKNKIENFF QSTIKKSYEY LHSLTKYEHI WKIDIKKEFL SFKKKNEIQL YPTYFEYNNN
FQDSLKLINI NIPYLFPNVL AYKKLILTLK QDLNKFYHLK TYEPINFILF YSENFVEKLI
NFTKKNISLY SEYLQNFVKD VVYSINSFYE NVINNLKEIS IVDFFSKKGD SKKEILEKGE
TNTGLQKGEK NVRLKKESID NMDISKMDNN NNQMNDDNNQ MNDFDDNDKM IDLDDNDKMI
DFDDDDNNNI YDESKRYKNK NALKNEVEEK EKEKTNVSNI NKKKDIFYNL MRNLRSVKLS
RKIIPLIFQK IKEIMENLKE LDIIIKYNDI LDNIEKNKEK VEIQYNDIKE KILKYKNNEI
KNIKLEIKDF KEELTKLKKH IFKNIPSTPK DIYNFPYEKI NEFRKSFQTY KDKQKYHNEL
EILFEIDITI FDELDQIDIK LTDLKHLWDL VNSIIFFIEQ EKKKLWKNID VNSNIYLIDF
ISLYIRKNFF DLKHLSIYEY IIKELKKLSS ILPLLVDLNN ECIFDRHWNI IINISGNINN
LYTKKKENNN NNNNNQNNYI NNTDLLNTPL SNNNKTSIMS IHTFNKEEQI NNDNTYDNEK
ETNNNIFLNK NIQIKYKELT LQGFFDLKLY KHVDAVHDVI EQAKKEQKIE NKIKEINVIW
KEMNFEFFKK NNYIQITNMD MILEIVDVHT SEILFFINQK KFILFIQETI LNTQENLKKI
DEVINIWRKF LNKFERLQPI YLNSEDIHSQ LPEESKMFFN IENEYKEIIH SAAEQKNVLQ
VCLNEDLFYL LSKFFKNIEL CEKALNDYLD QKKKAFPRFY FLSNIALLDI LSNGKNPFKI
LPYINDVFNA IKTIQFKEDL VQRGPVSELN EQNEENDLVK NEERSETQKD QKDQKDQKDQ
KDQKDQKDQK DQKDQKDQKD QKDQKDQKDQ KDQKDQKDQK NVNTDGKMDG YTDDKMNGYT
NDASYYGQEE DETYEGENKK CKDIKTCESK DYIAKGVYSV ENEHLEFLNE LVLKGNVENY
LKDLETHLKV TIRSILENAK ICSENLDEQN RDETMITNYI SQVVCTCNQI IVTEEINKCF
DELENGNESA FVDYKKVLIE RINKLIKLVE KTDDYNIRTK LLSLIILDVH TRDVIISFIK
KKISDSTSFD WQAQLKYYWV YDKKINNYTC EIKLCDFKTK YLYEYIGNSG KLVITPLTDK
CYITLTQALN LILGGAPAGP AGTGKTETTK DLSKAIGIAI FIFNCSNQMN YFNMSQICIG
LSQTGAWGCF DEFNRISIEV LSVVSTQIKC IFDAIKEKKT MFHFIDDEIV LKKTCGFFIT
MNPGYAGRTE LPENLKNLFR SCSMIVPDIK FICENMLMSF GFIKANKLSY KFVELYQLCK
ELLQKNIHYD WGLRAVKVVL IQAGNLKRKY ANFDEEIILM KALKDFNIPK ITYEDIPIFL
GLINDLFPNV NCNIFDEKDQ EKENDYDEEH KQEQQTYIIQ DEEKKLYKKK KNIHHNIDKY
KSSITQNFTN ANDNKNHLSI NKDNYETNKN LLTHYQHDIC EDISQIDKTK KDVQIYDEAH
NEKSDINELN QKTNIIANQN VNENYINNKE YDKDSNKIDN LKQNKFMNEE KRIIIHNFDD
AIKICLKESN LQIDDNFILK VKQLKDLMDV RHCVFILGED GCGKSSVIDI LIKSLNKINE
KCLYEIINPK SIESYELYGY LTKNNEWIDG ALSSIMRKMS RNISPYNENI KHKITLLDGN
IDAEWIESMN TVMDDNKVLT LVSNERIPFT KEMHLFFEIT NMKYASPATV SRGGVLFINK
GDISYKLFIS SWINLLNNNI AKTEFYYLFN IFYSQNIDML RKQCKFAFDL SNLDIVKSIC
NYIDYFLYKY EKYINEVIKK IENKQNEEIT FMKNENNRED LSNSNMKRKD KTTKDKDTKE
INDIHNKDIK THEKGSQKMD KKTNSFKDKI ITNDNESKLK HQKNMNHVDD IKMNTKNLIN
NEEKNIINKI NYNYEILKDY YNCFFMNSYM WVINNLIIDD KIMNSKNIFS NNIKSNLKVK
MGNDYCCNYI YNIYENNWKH LSEYLDEDIL FLQKLKWKTS EMENEEKGYE HEVVLEGDED
DNMDDANENM DDANENMDDT NENMDETNEN MDETNENMDD TNENVDDIHD NMDDTHDNMD
EKKKKKLIKN KKKKKKAINN YIENMLPNNY DDIYINTIEL IRIEKMIKYC LERNQAILVY
GNNGTGKTKC IKNNINMNIE KFTHTIISIN YYTNSFVLQK IIENNVEKRN TRTYGPPNQK
KHIFFLEDLN ITAKDNCDTQ QTLEFLRQLL TYKLIYDRDN LDEKKFIHDI SFIGTINNNT
NKLIDKRIQN KFSIINIDDI SMKTFENIYK IILKQHLLKF DDSIKCLLNN IISFSYDLYT
NITENISFNL SNLAPHYLFN LNDIHTIFYN IIKCTNPDIY NNQFKFLMIV FHEMQHAYIN
KLISDDHINI FTQLFNKLVQ QYFPFFKEDF EKHIDMFDST NEPHNVEHGQ DITSNKSLTF
HENDNVDDDT YNNNMDNGFK NDRNVNNNNI DGDDNGDGIN VRTVEKTHLD MSNNLNNSND
KDNIMKMKKS NNINTDSYNN NNINVKVKEK NLIYDLNKNI FTSFISIRNG LDKMYLNVKK
FYVLKEVLTE KLNEYNTTHV ELPLVLFDYA IIQICKICRI LDFNISHLML IGFGGSGKQS
LIKLSIFINS LNLLNISTNN NYDVNNFKSD LQEFHLKCAI KPGNVHVLLL KENDILDSFL
PYINDLTSTG LCNDLFTKDE YLGIFSSIRN QIKYLNIGES NEDVFNYYIN KIKTNFKIAI
THSPISNLYR DRLIKFPSFL SNFSFIYFLP WPYEALVNVS NKFLSDIKIK QDLKKKICEH
MAYVHTSTNE MNKKYLEQKI RYNYVIPKTF LEYIYFYKNL LNVKNFEIEK SVERLNKGLL
ALTSTRENVQ LLQKEIEIKI TNIEEKKIEV NEILNKVKEA TEVTNKEQQI VNEEKKKTEI
FTKEAIEIQL KADKELSEAL PIMNKAKDAV NCITKSAIQE LKSLQNPPKE CLDVTHAVLI
ALKEIKNYSW KFAQKIMNNP TQFLSKLQKF DAENMDEETV NLLTPFIQKK FFNYEMMKTK
SSACAYLALW LVNIVKYNEV YKKVKPLMDK LQEATNNKNK AQEKLDQLEN KVKELTDSVE
KLRRKMNEVN EEKNNVIKIY NESKDKLNRA ENLVNMLSDE YSRWSDEIAI INSNKKFIYG
DCLLLSSFIT YLGVFSSSFR IKLWKHLWLE HIKNSNILIN NITSPIDIMV QDIQIATWKN
EKLPEDIISI ENALIVSTCY RWPLLIDPQL QGLKWLKAKG GNNITVLQFN CDHFIKKIKN
VISKGGYLII ENISEEIDNV IDGLLNREFI KKGNDIYIKI DNEEMLFNYP NAINRIDKIK
SFFETNINSN TATTTTTTTN NNNNNNNNDN ITINNSGASQ INNTNNDNNN ITIDNQNNYG
NEPGDSNKNY HKQNSQNMNK AFSSENLYKV NFFNLILQTK LSNPHFKPEV NSQCTLINFS
VTCEGLEEQI LAIIVNIEKP ELEKQKQILV KNRNEYKIIL NNLEDEILYQ LSTVDSKTII
DNISLINSLK TTKDTSINIQ KQVADSINTE NEINKTRELY RTLANEASIV YFILILMHNI
NYMYQYSLDS FINLLLKSIE VVNSDSMKML SNKNLDSQIS NNNHMYDDDD NNNNNNGEHR
HLQKHDDKYY DSKIYLNDND ENNNNNNDDN NNNNNNINNV YDEHMNKLII SFRKTIYSWI
NRGLLEKDKL LFNCIFVFKL LEKKKIYDKD FNMDYLNFFL KPPRGKGVTE NPLKEWLSDD
CWENILILSK FKEFENLSNN IHIDAQHKFK QWCSEIQPEI CKLPLEWKKL NNYSFKKLLI
IRSLRPDRIT VTLEKYIKSI LPNSEEIMEK KNSFVDTLES SYNFMVNSTP ILFILTPGSD
FIKYVEILGK KYKFYLNQNL HVVSLGQGQE SIALSKLELS HKEGHWIVLE NIHLMAKFNL
ILENVIDKYA TEGSHPNFRC FLTSEITTNI PISILERSIK LTNEAPTGFK ENLKRAFTFF
SPDDYEEKDL RTKNILFSLC YFHSIIVERA KFGSQGFNIK YPFSLSDLRD SAKVLFNYLD
NQNSIKVPWN DLKYIFGEIM YGGHIVNDKD MLICKTYLNY FMKEQSLEGM QLIPFSKNIQ
LFSPNNYSYE KILKYIDTQI IFESSILYGL NQHAEMNFRT NESIKLLKNI LKLKLKETST
FVEELTTGET KENKTSNILS EILSEIDNIF FNVEELMKSI PDDQITPLQY FLFQECTLMN
SLTSVMKNSL KELNLAIKGE INMTSKIESL MNALYKDKLP ELWKNNSYSS NRNLSSWVNN
LKERIAFLTE WFNDPLLTPK VFNISLLFNP NSFFSAIKQI LSRNEKCELD KIIMQIEVTN
KSLNNIHSYP KEGAYIYGLY LDGANYDVEK NTLCDSSSKQ KYFLMPVIHC KPIVSMGKID
TDVYECPVYK TLSRGPTYVT NIKLKTKESS EKWILAGVAL ILDIADD
//