ID   Q8ILL4_PLAF7            Unreviewed;      1468 AA.
AC   Q8ILL4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 2.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Vacuolar protein sorting-associated protein 3, putative {ECO:0000313|EMBL:CZT99944.1};
GN   ORFNames=PF3D7_1423800 {ECO:0000313|EMBL:CZT99944.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT99944.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|EMBL:CZT99944.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
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DR   EMBL; LN999946; CZT99944.1; -; Genomic_DNA.
DR   RefSeq; XP_001348403.2; XM_001348367.2.
DR   AlphaFoldDB; Q8ILL4; -.
DR   IntAct; Q8ILL4; 1.
DR   STRING; 36329.Q8ILL4; -.
DR   PaxDb; 5833-PF14_0229; -.
DR   EnsemblProtists; CZT99944; CZT99944; PF3D7_1423800.
DR   GeneID; 811811; -.
DR   KEGG; pfa:PF3D7_1423800; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1423800; -.
DR   HOGENOM; CLU_005628_0_0_1; -.
DR   InParanoid; Q8ILL4; -.
DR   OMA; KYCLYHN; -.
DR   OrthoDB; 247846at2759; -.
DR   PhylomeDB; Q8ILL4; -.
DR   Proteomes; UP000001450; Chromosome 14.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IBA:GO_Central.
DR   GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR   InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12894; CNH DOMAIN CONTAINING; 1.
DR   PANTHER; PTHR12894:SF27; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF10367; Vps39_2; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50219; CNH; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          14..310
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          763..829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        763..820
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1468 AA;  176735 MW;  0833DD2E59F91A35 CRC64;
     MDLFKRESVN LNLNYEITFS CCIKDILYVG SKDGIIYEYE LIKEDPRCDD IKKEYMKNER
     SPNYNNLTDL NSLKGSLKVK PVGSHLIKKN KIINNIIIVE EKENIFIMLI LVDDILYYGK
     NNNLEVLNII YKNVLLYTIN ENNINELLIY TKKKKLYIYK YENGLYKYFK EITNPLNDLI
     SCLVWINDSL FLTINKEYYF LNIKNNQKIL LYSHEYEQTY KKITLINMNE IFIVCDLNIG
     VFYDVDTSMP SRKNTIILSP NIKQIISFRF FLFCLNFKGI INIYNIKNQQ HIQEITLNYI
     PDIVINYTNI TKYSTFLCLF NDDDQDNGEK ILSTQKNKNK WTSSDIGIKF YEEKIKKNRN
     LLKMEDEGIL SKSTMENDFF SGFSPKGIYD DDDDNNNNNN NNSNILFNKY LYENNEMLTK
     KNRNLYNSLY NNLYFINKDC LQILTCLEIY QYLPQCIEQG NTKKGFVLID NFVCESKKEK
     YDIFCEYNKA CAYYFFKNLN FSISFIFFQK VNINIFFLLF FWIDYLPSSH KNILQNMIEN
     KRIEENINKQ FKCFVPFPCS IKELIDRNYE NYIKDKPDYY ISNNMFDDFY NEDDDNDKNS
     LIYSSLQRDI EIKKHLLHTA NKCLVKFLLI KRDHFLQNKD MYKLSYKKEN DDSIHVNNNI
     HIIDELIDTL LIKLLTINNY NKQFFHFIMQ TSKLHVDLEE CVQFLKKEGK FVEIIFLYIR
     LGYFEEAIEI CSYFFHYYNE KYNVIQSTAD IGVYKYEIGQ EGNNEKKTKN DDKKKKKSDD
     EKKKKSDDEK KKKSDDEKKK KSDDEKKKKS DDKKNDDDNN NNSDNNFCNN NIYNNNIYND
     VRKKVEENNQ YSFFNIKELN KEKYLTWIKI FEKENAHKNN VLDKKNNNFQ YSLEKIYNIL
     IILNDHIHLL NVHQEKIKKL FEYAFPFLIK YNEHFFFHFL KKKNILISPE EIITIFKKMI
     QIDKKNDKIK YYLQKYIIHY LKHDKYNKNI NTTLIELYIN NVQTKNNKTH FQKKLITFML
     YEYPIHINYL TGIIKNTSFY LFKVLLYAKL HRHYESLQIL ADQNLRVCEK YCLYHNFILK
     KEVSKIKEEK YQELYNGIYN NDKNIYYNIF QKFIDRQINS AEKKNWNKTV NNKTKNTGFI
     KYILNEYHKY IYFSMNKNIP SKFLFHKKNE TLNKAYVQEM DQRNIIKKNK KIAQENKNIL
     VQNEYDYMLH LIKDHQEDEE VDNENDQLDD DILNYYETCS DESGECYTSD IICDATISSD
     DHKNYDNKSD MITSDNSTSS NNKTKKIIKT SAQDKLLKGK HRNKDPDPLA HFHVYNNCKK
     NTGGLFFLLI KVYLDKYYNE EMNLMKKKQY KNNILYILNK YANHNDLDNI YIFNIIPKYW
     NISEISQFIN FNLKKKRNTH MNLQIYHNLI KSNYLNVSYE KIKKKEQKII IKDKIFCKVC
     NNPILEKSFA FFSENITVHI HCIEKYDE
//