ID Q8IM03_PLAF7 Unreviewed; 382 AA.
AC Q8IM03;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=DNA damage-inducible protein 1, putative {ECO:0000313|EMBL:CZT99801.1};
GN ORFNames=PF3D7_1409300 {ECO:0000313|EMBL:CZT99801.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT99801.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT99801.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- SIMILARITY: Belongs to the DDI1 family.
CC {ECO:0000256|ARBA:ARBA00009136}.
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DR EMBL; LN999946; CZT99801.1; -; Genomic_DNA.
DR RefSeq; XP_001348263.1; XM_001348227.1.
DR AlphaFoldDB; Q8IM03; -.
DR SMR; Q8IM03; -.
DR STRING; 36329.Q8IM03; -.
DR MEROPS; A28.A07; -.
DR PaxDb; 5833-PF14_0090; -.
DR EnsemblProtists; CZT99801; CZT99801; PF3D7_1409300.
DR GeneID; 811671; -.
DR KEGG; pfa:PF3D7_1409300; -.
DR VEuPathDB; PlasmoDB:PF3D7_1409300; -.
DR HOGENOM; CLU_020435_1_0_1; -.
DR InParanoid; Q8IM03; -.
DR OMA; YMLYIPV; -.
DR OrthoDB; 1332686at2759; -.
DR PhylomeDB; Q8IM03; -.
DR Proteomes; UP000001450; Chromosome 14.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05479; RP_DDI; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR019103; Peptidase_aspartic_DDI1-type.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12917; ASPARTYL PROTEASE DDI-RELATED; 1.
DR PANTHER; PTHR12917:SF1; AT13091P; 1.
DR Pfam; PF09668; Asp_protease; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 222..345
FT /note="Aspartic peptidase DDI1-type"
FT /evidence="ECO:0000259|Pfam:PF09668"
FT COILED 172..206
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 382 AA; 43839 MW; CDA795FB458B186E CRC64;
MVFITISDDN NIITSLDVHE DTEIWTITNI IENDFSLNMN INELTYNGNA VDKFDTIKKL
NIKEGDLLFV RKKISADIMN DNVNNMSALN NILSTNNNVG NIGNIGNNLN NENVQNLLNN
PAFKTLLDQF KVYQENEYIK KESEILLEMK NDKSKMAVLK LQDEPLYNAI FSQNLEEIKK
IVKEKYETEK KEKEKEQQMY ENALKNPLSE DSQKFIYENI YKNEINNNLA LAQEHFPEAF
GVVFMLYIPV EINKNTVHAF VDSGAQSSIM SKKCAQKCNI LRLMDKRFTG IAKGVGTKTI
LGKIHMIDIK IGNYFYAVSL TIIEDYDIDF IFGLDLLKRH QCLIDFKQNA LIIEDNKIPF
LSEKDVISIS TQSIDIDANN DL
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