ID Q8IR23_DROME Unreviewed; 954 AA.
AC Q8IR23;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 2.
DT 27-MAR-2024, entry version 186.
DE SubName: Full=GH13542p {ECO:0000313|EMBL:ACH92514.1};
DE SubName: Full=RasGap protein {ECO:0000313|EMBL:CAA10073.1};
DE SubName: Full=Vacuolar peduncle, isoform A {ECO:0000313|EMBL:AAN09381.2};
DE SubName: Full=Vacuolar peduncle, isoform B {ECO:0000313|EMBL:AAF48558.2};
DE SubName: Full=Vacuolar peduncle, isoform C {ECO:0000313|EMBL:AAN09380.1};
DE SubName: Full=Vacuolar peduncle, isoform D {ECO:0000313|EMBL:AAS65383.1};
DE SubName: Full=Vacuolar peduncle, isoform E {ECO:0000313|EMBL:AHN59784.1};
DE SubName: Full=Vacuolar peduncle, isoform F {ECO:0000313|EMBL:AHN59785.1};
GN Name=vap {ECO:0000313|EMBL:AAN09381.2,
GN ECO:0000313|FlyBase:FBgn0003969};
GN Synonyms=D-RasGAP {ECO:0000313|EMBL:AAN09381.2}, Dmel\CG9209
GN {ECO:0000313|EMBL:AAN09381.2}, FBpp0073946
GN {ECO:0000313|EMBL:AAN09381.2}, p120 RasGAP
GN {ECO:0000313|EMBL:AAN09381.2}, p120RasGAP
GN {ECO:0000313|EMBL:AAN09381.2}, RAS-GAP {ECO:0000313|EMBL:AAN09381.2},
GN RasGAP {ECO:0000313|EMBL:AAN09381.2}, RasGap
GN {ECO:0000313|EMBL:AAN09381.2}, rasGap {ECO:0000313|EMBL:AAN09381.2},
GN RasGAP/Vap {ECO:0000313|EMBL:AAN09381.2}, vap-RA
GN {ECO:0000313|EMBL:ACH92514.1};
GN ORFNames=CG9209 {ECO:0000313|EMBL:AAN09381.2,
GN ECO:0000313|FlyBase:FBgn0003969}, Dmel_CG9209
GN {ECO:0000313|EMBL:AAN09381.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:CAA10073.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Oregon-R {ECO:0000313|EMBL:CAA10073.1};
RX PubMed=10022880;
RA Feldmann P., Eicher E.N., Leevers S.J., Hafen E., Hughes D.A.;
RT "Control of growth and differentiation by Drosophila RasGAP, a homolog of
RT p120 Ras-GTPase-activating protein.";
RL Mol. Cell. Biol. 19:1928-1937(1999).
RN [2] {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [4] {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5] {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [6] {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [7] {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [8] {ECO:0000313|EMBL:AAN09381.2}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [10] {ECO:0000313|EMBL:AAN09381.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [11] {ECO:0000313|EMBL:ACH92514.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Berkeley {ECO:0000313|EMBL:ACH92514.1};
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:AAN09381.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [13] {ECO:0000313|EMBL:AAN09381.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [14] {ECO:0000313|EMBL:AAN09381.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [15] {ECO:0000313|EMBL:AAN09381.2}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:AAN09381.2}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE014298; AAF48558.2; -; Genomic_DNA.
DR EMBL; AE014298; AAN09380.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09381.2; -; Genomic_DNA.
DR EMBL; AE014298; AAS65383.1; -; Genomic_DNA.
DR EMBL; BT044449; ACH92514.1; -; mRNA.
DR EMBL; AE014298; AHN59784.1; -; Genomic_DNA.
DR EMBL; AE014298; AHN59785.1; -; Genomic_DNA.
DR EMBL; AJ012609; CAA10073.1; -; mRNA.
DR RefSeq; NP_001285314.1; NM_001298385.1.
DR RefSeq; NP_001285315.1; NM_001298386.1.
DR RefSeq; NP_523361.1; NM_078637.3.
DR RefSeq; NP_727925.1; NM_167480.2.
DR RefSeq; NP_727926.2; NM_167481.3.
DR RefSeq; NP_996482.1; NM_206759.2.
DR AlphaFoldDB; Q8IR23; -.
DR SMR; Q8IR23; -.
DR IntAct; Q8IR23; 3.
DR MINT; Q8IR23; -.
DR STRING; 7227.FBpp0309361; -.
DR PaxDb; 7227-FBpp0073945; -.
DR DNASU; 32569; -.
DR EnsemblMetazoa; FBtr0074140; FBpp0073945; FBgn0003969.
DR EnsemblMetazoa; FBtr0074141; FBpp0073946; FBgn0003969.
DR EnsemblMetazoa; FBtr0074142; FBpp0089147; FBgn0003969.
DR EnsemblMetazoa; FBtr0074143; FBpp0089148; FBgn0003969.
DR EnsemblMetazoa; FBtr0340415; FBpp0309361; FBgn0003969.
DR EnsemblMetazoa; FBtr0340416; FBpp0309362; FBgn0003969.
DR GeneID; 32569; -.
DR KEGG; dme:Dmel_CG9209; -.
DR UCSC; CG9209-RA; d. melanogaster.
DR AGR; FB:FBgn0003969; -.
DR CTD; 32569; -.
DR FlyBase; FBgn0003969; vap.
DR VEuPathDB; VectorBase:FBgn0003969; -.
DR eggNOG; KOG3508; Eukaryota.
DR GeneTree; ENSGT00940000155846; -.
DR HOGENOM; CLU_010968_1_0_1; -.
DR InParanoid; Q8IR23; -.
DR OMA; ICGCLQR; -.
DR OrthoDB; 22721at2759; -.
DR Reactome; R-DME-186763; Downstream signal transduction.
DR Reactome; R-DME-3928662; EPHB-mediated forward signaling.
DR Reactome; R-DME-5218921; VEGFR2 mediated cell proliferation.
DR Reactome; R-DME-5658442; Regulation of RAS by GAPs.
DR Reactome; R-DME-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
DR BioGRID-ORCS; 32569; 0 hits in 1 CRISPR screen.
DR ChiTaRS; vap; fly.
DR GenomeRNAi; 32569; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0003969; Expressed in embryonic/larval hemocyte (Drosophila) and 33 other cell types or tissues.
DR ExpressionAtlas; Q8IR23; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IDA:FlyBase.
DR GO; GO:0005096; F:GTPase activator activity; IDA:FlyBase.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IDA:FlyBase.
DR GO; GO:0005122; F:torso binding; IDA:FlyBase.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0048149; P:behavioral response to ethanol; IMP:FlyBase.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR GO; GO:0016319; P:mushroom body development; IMP:FlyBase.
DR GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IGI:FlyBase.
DR GO; GO:0120177; P:negative regulation of torso signaling pathway; IMP:FlyBase.
DR GO; GO:0030100; P:regulation of endocytosis; IMP:FlyBase.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 84..174
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 181..243
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 253..341
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 380..485
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 484..598
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 654..848
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 954 AA; 107950 MW; B9041102FD6C6F57 CRC64;
MADLIHLGNI DVVIQKDKPG SPTGCSDDGN LAGLGGMTGL GGIMAPGGID LGDLAQELDH
DEFDGPHMLN GERPAIIAPP ESEWYHGRLD RYSAESRLRG SSKLGSYLVR ESDRKPGSYV
LSYYGRTGIN HFRITAVCGD FYIGGRQFIS LSDLVGYYTS CSDLLKRERL AIPVAPPEPV
NDKKRVVAIL PYTKMPETDE LSFQKGDIFF VHNDMGDGWL WVTAHRTGEQ GMIFRELVDD
LDVSIDPNTV FPWFHPNCTK NEAVDMLVKA GPGSFLVRPS DNSPGDYSLF FHINNQIQRF
RIEKKGVRYL MGGRTFECLD AVINRYRKEQ IVEGHSLNHP VVNGIQPEFN QQYVVEKAAE
KIYATLRECR DQIGLKKIKG IKHHGHLNKK SDKTTKWKQL YFALINDGSE TQLCFYDNPK
KTKPKGLIDL SCAYLYQCHD SLWERPYCFQ IVERALPCLA TVTYLCAPSQ ESYVEWINSL
KAQCDSQLSR AQKKVSRLRE LRCLNLHVLE AHRLPFKLVP HPYCSISLNQ VKVGKTRVKI
APEPVWEEEF VLDDVPPDVV SLTITLISRG KRGKDSEVAE LTIDLSSLKN GQETEGWYQL
TGMTPMGEWG SLRLRMRYLD DLIMPCEEYS PLQQLLLESE LYAVKALAEL CHNDRVPLAT
ALLRVFRQEK RETELIRMLC QAEVTRENET TTLFRGASLA TTLMDLYMRT ECSGFLQSAV
SETVQRILES KQSAELNPTK MDVNDDACTN AEFLLQILDL VTQSIFTSPD ACPRNVRFIC
SCLQKAVMAK WPTERLVRTR VVSGFIFLRL LCPALLNPRQ FGLVSETPPM AATRSLVMVA
KCLQNLANLI EFGGKEQYME VVNPFILKNK ERMIVFLDQL SSVNDPNQPL GMFVEQSTNL
NSQDTGRELA TLHHICVSHS QELHELSNIL SIKKLVTVTD MLTKHKLKYR EMIS
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