ID Q8ITW4_CAEEL Unreviewed; 784 AA.
AC Q8ITW4;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 143.
DE SubName: Full=FERM and PDZ domain-containing protein 4 {ECO:0000313|EMBL:CCD72290.1};
GN Name=frm-8 {ECO:0000313|EMBL:CCD72290.1,
GN ECO:0000313|WormBase:H09G03.2c};
GN ORFNames=CELE_H09G03.2 {ECO:0000313|EMBL:CCD72290.1}, H09G03.2
GN {ECO:0000313|WormBase:H09G03.2c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD72290.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD72290.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72290.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284603; CCD72290.1; -; Genomic_DNA.
DR RefSeq; NP_497672.2; NM_065271.4.
DR AlphaFoldDB; Q8ITW4; -.
DR SMR; Q8ITW4; -.
DR IntAct; Q8ITW4; 1.
DR EPD; Q8ITW4; -.
DR PeptideAtlas; Q8ITW4; -.
DR EnsemblMetazoa; H09G03.2c.1; H09G03.2c.1; WBGene00001494.
DR GeneID; 175428; -.
DR UCSC; H09G03.2a; c. elegans.
DR AGR; WB:WBGene00001494; -.
DR WormBase; H09G03.2c; CE32455; WBGene00001494; frm-8.
DR OrthoDB; 2878981at2759; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00001494; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; Q8ITW4; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17088; FERM_F1_FRMPD1_like; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR46221; FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46221:SF3; FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 53..86
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 95..172
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 208..547
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 88345 MW; 069517FCF408CAAF CRC64;
MIKSKSLQFH AGGSQSPPKR ICCSGSVDEI KDLIHTTRSS HWEPPWASWR CRLGLPYGWE
QAKDNDGNTY YIDHLNRTTT YTDPRKTRPP DGKRTVSIRR GKDIGFGFVA AGQLPTIIQF
VSPEGPSDGL LYANDQILEV NGLDMQNETK DNVVNAVRAA KEELQITVQQ LPQRPKSSRK
NCKVRFTDRV LVSSTNDNNS EFPPLLPNVL RVYLENGQTR SFKYDQSTTV KQILESILEK
LQISAKSHFS LAVEYSLGAR TSRISLLRPD CKIKSIVDLP NSEHLRCVFR LSFAPSDAFV
LLLSDPKALE YYYQQCVNDV VRGRFAMEMR YEACIRLAAL HVQQVAYDCN ILKENNKVSV
HRVEKEYGLG TFLPAIVLEN VKRRDVRKHI RFYLKRDSSR LVDCFGKPTI GNGYPPELEA
CAAQFANEPS MMVRLRYIHI VSHLPSFGGR SFCVTFKESQ IDMLMQVEPR TGLLVRHPGK
SGQPSISIGF DLIGKLVVCK ETEVASMISI RLASNPHQGL EFLVDKDDLD DLVMYIVGYH
KVTYEKDLLL EIDDSPPKLR ELPDKAPPYS AIHTVVKSDW NYSETSSQTE KPFDPTDGPP
SYEIANSFVQ IAFENEQNED HFDTEISRQN GESFTPKRAH FEPKKLLRAT DSLLIKNSRD
LHAKELEIQN GGSQNDESSD TEDSSFSSPL RSPNIDRLCD GINLLVTGPP ARRASIETLL
QNNQNPNTNL ESLILQFPTI PDENEVENDD VALPEGMQTS TTTVVANGKT RCYRNGSCAK
SYQG
//
